The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
CTX-M: changing the face of ESBLs in Europe
Abstract
Since around 2000 - earlier in Poland and Spain and later in France and the UK - dramatic shifts have occurred in the prevalence and types of extended-spectrum beta-lactamases (ESBLs) in Europe. Before this watershed, most producers were nosocomial isolates, often Klebsiella spp. or Enterobacter spp. from specialist care units, and had mutant TEM or SHV ESBLs. Subsequently, CTX-M ESBLs have become dominant, with much greater penetration into Escherichia coli, and with many infections in 'complicated community' patients, usually with underlying disease, recent antibiotic usage, or healthcare contact. The degree of clonality among producers varies with the country, as does the enzyme type produced, with group 9 (CTX-M-9 and -14) enzymes dominant in Spain and group 1 enzymes (particularly CTX-M-3 and -15) dominant elsewhere. Irrespective of the particular enzyme, most producers are multiresistant. These changing patterns present major therapeutic and infection control challenges, with the public health intervention points unclear.
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Eckert, C., Gautier, V., Saladin-Allard, M., Hidri, N., Verdet, C., Ould-Hocine, Z., Barnaud, G., Delisle, F., Rossier, A., Lambert, T., et al. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.4.1249-1255.2004 · Cited by 278
Self-citation
Cited by
Origins and evolution of antibiotic resistance
Davies, J., & Davies, D. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00016-10 · Cited by 5,784
Kumarasamy, K. K., Toleman, M. A., Walsh, T. R., Bagaria, J., Butt, F., Balakrishnan, R., Chaudhary, U., Doumith, M., Giske, C. G., Irfan, S., et al. (2010) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(10)70143-2 · Cited by 2,922
Self-citationEpidemiology of β-Lactamase-Producing Pathogens
Bush, K., & Bradford, P. A. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00047-19 · Cited by 938
The changing epidemiology of resistance
Hawkey, P. M., & Jones, A. M. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp256 · Cited by 773
Peirano, G., & Pitout, J. D. D. (2010) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2009.11.003 · Cited by 443
Metadata
- Authors
- Livermore, D. M., Canton, R., Gniadkowski, M., Nordmann, P., Rossolini, G. M., Arlet, G., Ayala, J., Coque, T. M., Kern-Zdanowicz, I., Luzzaro, F., Poirel, L., & Woodford, N.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11-13
- Volume
- 59
- Issue
- 2
- Pages
- 165-174
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2108864681
- Cited by
- 927
- References
- 1
- FWCI
- 24.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Livermore, D. M., Canton, R., Gniadkowski, M., Nordmann, P., Rossolini, G. M., Arlet, G., Ayala, J., Coque, T. M., Kern-Zdanowicz, I., Luzzaro, F., Poirel, L., & Woodford, N. (2006). CTX-M: changing the face of ESBLs in Europe. Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/dkl483
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