The mother as most important risk factor for colonization of very low birth weight (VLBW) infants with extended-spectrum -lactamase-producing Enterobacteriaceae (ESBL-E)
Abstract
Objectives This study aimed to determine the prevalence of and risk factors for colonization with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) and methicillin-resistant Staphylococcus aureus (MRSA) in very low birth weight (VLBW; Methods This investigation was conducted in the perinatal centre at the Charité Berlin between May 2012 and June 2013. VLBW infants and their mothers were screened for colonization with ESBL-E and MRSA. Demographic and clinical data were obtained from the German nationwide surveillance system for nosocomial infections in VLBW infants (NEO-KISS) and used to perform univariate and multivariate analyses. Results Of 209 VLBW infants, 12 (5.7%) were colonized with ESBL-E. Eighteen of 209 (8.6%) ESBL-E-tested neonates were related to an ESBL-E-positive mother. Univariate analysis, strain typing and multivariate analysis (OR 7.4, 95% CI 2.1-26.7, P = 0.002) identified an ESBL-E-positive mother and maternal-neonatal transmission as a main source of colonization. The prevalence of MRSA was 2.3% (5 of 221) among VLBW infants. One of the 221 (0.5%) MRSA-tested neonates was related to an MRSA-positive mother. No risk factors for transmission of MRSA could be detected in this study. Conclusions Our study demonstrated that maternal-neonatal transmission of ESBL-E from mother to child is an important risk factor for colonization of VLBW infants. As a consequence, routine ESBL-E screening of neonates and mothers should be considered as a means…
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Several studies have confirmed the role of maternal colonization in the subsequent development of neonatal sepsis, particularly for group B Streptococcus but also for ESBL-E.
“Several studies have confirmed the role of maternal colonization in the subsequent development of neonatal sepsis (particularly for group B Streptococcus, but also for ESBL-E) (Chan et al., 2013;Kaba et al., 2016;Denkel et al., 2014;Rettedal et al., 2015).”
From Maternal colonization or infection with extended-spectrum beta-lactamase-producing Enterobacteriaceae in Africa: A systematic review and meta-analysis (2017) · cites this paper as Denkel et al., 2014
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Rettedal, S., Löhr, I. H., Bernhoff, E., Natås, O. B., Sundsfjord, A., & Øymar, K. (2015) · Journal of Perinatology · doi:10.1038/jp.2015.82 · Cited by 66 · see citing works
Bulabula, A. N. H., Dramowski, A., & Mehtar, S. (2017) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2017.08.015 · Cited by 59 · see citing works
- Authors
- Denkel, L. A., Schwab, F., Kola, A., Leistner, R., Garten, L., von Weizsacker, K., Geffers, C., Gastmeier, P., & Piening, B.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Denkel, L. A.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-04-11
- Volume
- 69
- Issue
- 8
- Pages
- 2230-2237
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2022063393
- Cited by
- 105
- References
- 0
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 15 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 7 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 3 · 2013: 1
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Antimicrobial Chemotherapy (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Keywords
- extended-spectrum beta-lactamase, Enterobacteriaceae, very low birth weight infants, maternal colonization, mother-to-child transmission, methicillin-resistant Staphylococcus aureus, neonatal colonization, risk factors, newborn screening, neonatal infection
- MeSH terms
- beta-Lactamases, Cross Infection, Enterobacteriaceae, Enterobacteriaceae Infections, Female, Gestational Age, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Male, Mothers, Risk Factors, Infectious Disease Transmission, Vertical, Infant, Very Low Birth Weight, Methicillin-Resistant Staphylococcus aureus
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