Extended-spectrum β-lactamase-producing Enterobacteriaceae among pregnant women in Norway: prevalence and maternal-neonatal transmission
Abstract
Objective To study (i) the prevalence and risk factors for carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) in pregnant women, (ii) the maternal-neonatal transmission rate of ESBL-E at birth and (iii) the prevalence of ESBL-E in expressed breast milk of colonized mothers. Study design In this cross-sectional, population-based study with case follow-up on maternal-neonatal transmission of ESBL-E, women were screened for rectal ESBL-E colonization at 36 weeks of pregnancy and delivery. Possible risk factors for colonization were studied by logistic regression. Infants of ESBL-E-positive mothers were screened for ESBL-E during their first weeks of life. ESBL-encoding genes were detected by PCR and clonal relatedness was investigated by pulsed-field gel electrophoreses. Results In total, 26 out of 901 (2.9%) women were colonized by ESBL-producing Escherichia coli at 36 weeks of pregnancy. One of the women carried an additional ESBL Klebsiella pneumoniae strain. Adjusted for traveling, African or Asian nationality was a risk factor for colonization; OR=5.62 (2.21, 14.27) (LR-p=0.003). Fourteen women remained ESBL-E carriers at delivery. ESBL-E strains indistinguishable from the strains isolated from their respective mothers were detected in 5 (35.7%) infants during their first days of life (median day 3; range=2 to 8). A total of 146 expressed milk samples were cultured from 25 out of 26 colonized mothers, all were ESBL-E negative. Conclusions The pr…
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The prevalence of colonization and/or infection with ESBL-E in pregnant and post-partum women in Africa exceeds that reported from high- and middle-income settings.
“The prevalence of colonization and/or infection with ESBL-E in pregnant and post-partum women in Africa exceeds that reported from high-and middle-income settings, representing a risk for subsequent neonatal colonization and/or infection with ESBL-E.”
From Maternal colonization or infection with extended-spectrum beta-lactamase-producing Enterobacteriaceae in Africa: A systematic review and meta-analysis (2017) · cites this paper as Rettedal et al., 2015
Maternal colonization and/or infection with ESBL-E in pregnant and post-partum women in Africa represents a risk for subsequent neonatal colonization and/or infection with ESBL-E.
“The prevalence of colonization and/or infection with ESBL-E in pregnant and post-partum women in Africa exceeds that reported from high-and middle-income settings, representing a risk for subsequent neonatal colonization and/or infection with ESBL-E.”
From Maternal colonization or infection with extended-spectrum beta-lactamase-producing Enterobacteriaceae in Africa: A systematic review and meta-analysis (2017) · cites this paper as Rettedal et al., 2015
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- Authors
- Rettedal, S., Löhr, I. H., Bernhoff, E., Natås, O. B., Sundsfjord, A., & Øymar, K.
- Affiliations
- Stavanger University Hospital (NO)
- University Hospital of North Norway (NO)
- Corresponding author
- Rettedal, S
- Venue
- Journal of Perinatology
- Published
- 2015-07-09
- Volume
- 35
- Issue
- 11
- Pages
- 907-912
- ISSN
- 0743-8346 (ISSN-L)
- 1476-5543
- OpenAlex
- W1854320954
- Cited by
- 66
- References
- 42
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 1
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Perinatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
- Keywords
- extended-spectrum beta-lactamase, ESBL-producing Enterobacteriaceae, pregnant women, maternal colonization, Escherichia coli, Klebsiella pneumoniae, breast milk, risk factors, international migration, infant colonization, clonal relatedness
- MeSH terms
- Adult, beta-Lactamases, Carrier State, Cross-Sectional Studies, Enterobacteriaceae, Enterobacteriaceae Infections, Female, Humans, Infant, Newborn, Norway, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Trimester, Third, Prenatal Diagnosis, Prevalence, Logistic Models, Infectious Disease Transmission, Vertical, Risk Assessment
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