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Global epidemiology of CTX-M β-lactamases: temporal and geographical shifts in genotype

Open access
Bevan, Edward R., Jones, Annie M., Hawkey, Peter M.·2017·Journal of Antimicrobial Chemotherapy

Abstract

Globally, rates of ESBL-producing Enterobacteriaceae are rising. We undertook a literature review, and present the temporal trends in blaCTX-M epidemiology, showing that blaCTX-M-15 and blaCTX-M-14 have displaced other genotypes in many parts of the world. Explanations for these changes can be attributed to: (i) horizontal gene transfer (HGT) of plasmids; (ii) successful Escherichia coli clones; (iii) ESBLs in food animals; (iv) the natural environment; and (v) human migration and access to basic sanitation. We also provide explanations for the changing epidemiology of blaCTX-M-2 and blaCTX-M-27. Modifiable anthropogenic factors, such as poor access to basic sanitary facilities, encourage the spread of blaCTX-M and other antimicrobial resistance (AMR) genes, such as blaNDM, blaKPC and mcr-1. We provide further justification for novel preventative and interventional strategies to reduce transmission of these AMR genes.

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Metadata

Authors
Bevan, E. R., Jones, A. M., & Hawkey, P. M.
Venue
Journal of Antimicrobial Chemotherapy
Published
2017-05-25
Volume
72
Issue
8
Pages
2145-2155
ISSN
  • 0305-7453 (ISSN-L)
  • 1460-2091
OpenAlex
W2619325951
Cited by
791
References
2
FWCI
19.69
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Global epidemiology of CTX-M β-lactamases: temporal and geographical shifts in genotype. https://app.cochat.ai/papers/10.1093/jac/dkx146
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Bevan, E. R., Jones, A. M., & Hawkey, P. M. (2017). Global epidemiology of CTX-M β-lactamases: temporal and geographical shifts in genotype. Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/dkx146

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.