Key takeaways from the U.S. CDC’s 2019 antibiotic resistance threats report for frontline providers

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock

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Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America

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Understanding the mechanisms and drivers of antimicrobial resistance

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The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace

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Global epidemiology of CTX-M β-lactamases: temporal and geographical shifts in genotype

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Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance

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First hospital outbreak of the globally emerging Candida auris in a European hospital

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<i>Vital Signs:</i> Epidemiology and Recent Trends in Methicillin-Resistant and in Methicillin-Susceptible <i>Staphylococcus aureus</i> Bloodstream Infections — United States

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Colistin Versus Ceftazidime-Avibactam in the Treatment of Infections Due to Carbapenem-Resistant Enterobacteriaceae

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The increasing threat of Pseudomonas aeruginosa high-risk clones

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Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial

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Difficult-to-Treat Resistance in Gram-negative Bacteremia at 173 US Hospitals: Retrospective Cohort Analysis of Prevalence, Predictors, and Outcome of Resistance to All First-line Agents

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Heteroresistance to Colistin in Multidrug-Resistant Acinetobacter baumannii

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Infections Caused by Carbapenem-Resistant Enterobacteriaceae: An Update on Therapeutic Options

Sheu, C., Chang, Y.-T., Lin, S., Chen, Y., & Hsueh, P. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00080 · Cited by 534 · see citing works

Colistin and Rifampicin Compared With Colistin Alone for the Treatment of Serious Infections Due to Extensively Drug-Resistant Acinetobacter baumannii: A Multicenter, Randomized Clinical Trial

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Prevalence of antibiotic-resistant pathogens in culture-proven sepsis and outcomes associated with inadequate and broad-spectrum empiric antibiotic use.

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Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study

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Excess Deaths Associated With Tigecycline After Approval Based on Noninferiority Trials

Prasad, P., Sun, J., Danner, R. L., & Natanson, C. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis270 · Cited by 298 · see citing works

Ceftolozane-Tazobactam for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infections: Clinical Effectiveness and Evolution of Resistance

Haidar, G., Phillips, N. J., Shields, R. K., Snyder, D. J., Cheng, S., Potoski, B. A., Doi, Y., Hao, B., Press, E. G., Cooper, V. S., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix182 · Cited by 279 · see citing works

Epidemiology of Invasive Group B Streptococcal Infections Among Nonpregnant Adults in the United States, 2008-2016

Watkins, L. F., McGee, L., Schrag, S. J., Beall, B., Jain, J. H., Pondo, T., Farley, M. M., Harrison, L. H., Zansky, S. M., Baumbach, J., et al. (2019) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2018.7269 · Cited by 210 · see citing works

Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis

Parks, T., Wilson, C., Curtis, N. C., Norrby‐Teglund, A., & Sriskandan, S. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy401 · Cited by 209 · see citing works

In vitro activity of cefiderocol, a siderophore cephalosporin, against a recent collection of clinically relevant carbapenem-non-susceptible Gram-negative bacilli, including serine carbapenemase- and metallo-β-lactamase-producing isolates (SIDERO-WT-2014 Study)

Kazmierczak, K. M., Tsuji, M., Wise, M. G. G., Hackel, M., Yamano, Y., ECHOLS, R. M., & Sahm, D. F. (2018) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2018.10.007 · Cited by 197 · see citing works

The Path to Group A Streptococcus Vaccines: World Health Organization Research and Development Technology Roadmap and Preferred Product Characteristics

Vekemans, J., Gouvea-Reis, F., Kim, J. H., Excler, J., Smeesters, P. R., O’Brien, K. L., Beneden, C. V., Steer, A. C., Carapetis, J. R., & Kaslow, D. C. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciy1143 · Cited by 176 · see citing works

Activity of the novel siderophore cephalosporin cefiderocol against multidrug-resistant Gram-negative pathogens

Dobias, J., Tendon, V. D., Poirel, L., & Nordmann, P. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-3063-z · Cited by 151 · see citing works

Multicenter Evaluation of Ceftolozane/Tazobactam for Serious Infections Caused by Carbapenem-Resistant Pseudomonas aeruginosa

Munita, J. M., Aitken, S. L., Miller, W. R., Pérez, F., Rosa, R. M., Shimose, L. A., Lichtenberger, P. K., Abbo, L. M., Jain, R., Nigo, M., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix014 · Cited by 142 · see citing works

Ceftolozane-Tazobactam for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infections: A Multicenter Study

Gallagher, J. C., Satlin, M. J., Elabor, A., Saraiya, N., McCreary, E. K., Molnar, E., El‐Beyrouty, C., Jones, B. M., Dixit, D., Heil, E. L., et al. (2018) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofy280 · Cited by 127 · see citing works

Re-estimating annual deaths due to multidrug-resistant organism infections

Burnham, J. P., Olsen, M. A. A., & Kollef, M. H. (2018) · Infection Control and Hospital Epidemiology · doi:10.1017/ice.2018.304 · Cited by 117 · see citing works

Age-related trends in pathogen frequency and antimicrobial susceptibility of bloodstream isolates in North America

Diekema, D. J., Pfaller, M. A., & Jones, R. N. (2002) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(02)00204-2 · Cited by 107 · see citing works

Impact of Difficult-to-Treat Resistance in Gram-negative Bacteremia on Mortality: Retrospective Analysis of Nationwide Surveillance Data

Huh, K., Chung, D. R., Ha, Y. E., Ko, J., Kim, S., Kim, M., Huh, H. J., Lee, N. Y., Cho, S. Y., Kang, C., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa084 · Cited by 104 · see citing works

Clindamycin Affects Group A Streptococcus Virulence Factors and Improves Clinical Outcome

Andreoni, F., Zürcher, C., Tarnutzer, A., Schilcher, K., Neff, A., Keller, N., Maggio, E. M., Poyart, C., Schuepbach, R. A., & Zinkernagel, A. S. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw229 · Cited by 96 · see citing works

Evaluation of the In Vitro Activity of Ceftazidime-Avibactam and Ceftolozane-Tazobactam against Meropenem-Resistant Pseudomonas aeruginosa Isolates

Buehrle, D. J., Shields, R. K., Chen, L., Hao, B., Press, E. G., Alkrouk, A., Potoski, B. A., Kreiswirth, B. N., Clancy, C. J., & Nguyen, M. H. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02969-15 · Cited by 95 · see citing works

Clinical activity of ceftazidime/avibactam against MDR Enterobacteriaceae and Pseudomonas aeruginosa: pooled data from the ceftazidime/avibactam Phase III clinical trial programme

Stone, G. G., Newell, P., Gasink, L. B., Broadhurst, H., Wardman, A., Yates, K., Chen, Z., Song, J., & Chow, J. W. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky204 · Cited by 77 · see citing works

High Prevalence of Macrolide-resistance and Molecular Characterization of Streptococcus pyogenes Isolates Circulating in China from 2009 to 2016

Lu, B., Fang, Y., Fan, Y., Chen, X., Wang, J., Zeng, J., Li, Y., Zhang, Z., Huang, L., Li, H., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01052 · Cited by 68 · see citing works

External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data From 140 US Hospitals

Kadri, S. S., Lai, Y. L., Ricotta, E., Strich, J. R., Babiker, A., Rhee, C., Klompas, M., Dekker, J. P., Powers, J. H., Danner, R. L., et al. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofz110 · Cited by 57 · see citing works

<i>Vital Signs</i>: Trends in <i>Staphylococcus aureus</i> Infections in Veterans Affairs Medical Centers — United States, 2005–2017

Jones, M., Jernigan, J. A., Evans, M. E., Roselle, G. A., Hatfield, K. M., & Samore, M. H. (2019) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6809e2 · Cited by 50 · see citing works

Prognostic Utility of the New Definition of Difficult-to-Treat Resistance Among Patients With Gram-Negative Bloodstream Infections

Giannella, M., Bussini, L., Pascale, R., Bartoletti, M., Malagrinò, M., Pancaldi, L., Toschi, A., Ferraro, G., Marconi, L., Ambretti, S., et al. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofz505 · Cited by 49 · see citing works

OXA-23 Is a Prevalent Mechanism Contributing to Sulbactam Resistance in Diverse Acinetobacter baumannii Clinical Strains

Yang, Y., Xu, Q., Li, T., Fu, Y., Shi, Y., Lan, P., Zhao, D., Chen, Q., Zhou, Z., Jiang, Y., et al. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01676-18 · Cited by 46 · see citing works

De Novo Daptomycin-Nonsusceptible Enterococcal Infections

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Linezolid and Vancomycin Resistant Enterococci: A Therapeutic Problem

Yadav, G. (2017) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2017/27260.10474 · Cited by 42 · see citing works

Pharmacoepidemiology of Ceftazidime-Avibactam Use: A Retrospective Cohort Analysis of 210 US Hospitals

Strich, J. R., Ricotta, E., Warner, S., Lai, Y. L., Demirkale, C. Y., Hohmann, S. F., Rhee, C., Klompas, M., Palmore, T. N., Powers, J. H., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa061 · Cited by 34 · see citing works

Critical Care Medicine and Infectious Diseases: An Emerging Combined Subspecialty in the United States: Figure 1.

Kadri, S. S., Rhee, C., Fortna, G. S., & O’Grady, N. P. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ360 · Cited by 23 · see citing works

Attributable mortality from extensively drug-resistant gram-negative infections using propensity-matched tracer antibiotic algorithms

Kadri, S. S., Strich, J. R., Swihart, B., Hohmann, S. F., Dekker, J. P., Palmore, T. N., Bonne, S. L., Freeman, B. D., Raybould, J. E., Shah, N. G., et al. (2019) · American Journal of Infection Control · doi:10.1016/j.ajic.2019.01.010 · Cited by 9 · see citing works

Synergy, Salary, and Satisfaction: Benefits of Training in Critical Care Medicine and Infectious Diseases Gleaned From a National Pilot Survey of Dually Trained Physicians

Kadri, S. S., Rhee, C., Magda, G., Strich, J. R., Cai, R., Sun, J., Decker, B. K., & O’Grady, N. P. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw441 · Cited by 7 · see citing works

Prevalence of antibiotic-resistant pathogens in culture-proven sepsis and outcomes associated with inadequate and broad-spectrum empiric antibiotic use.

Rhee, C., Kadri, S. S., Dekker, J. P., Danner, R. L., Chen, H.-C., Fram, D., Zhang, F., Wang, R., Klompas, M., & Program, F. T. C. P. E. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.2899 · Cited by 397 · see citing works

An Overview of the Recent Advances in Antimicrobial Resistance

Oliveira, M. T. D. S., Antunes, W., MOTA, S. R. F., Madureira-Carvalho, Á., Dinis‐Oliveira, R. J., & da Silva, D. D. (2024) · Microorganisms · doi:10.3390/microorganisms12091920 · Cited by 295 · see citing works

Taking phototherapeutics from concept to clinical launch

Vickerman, B. M., Zywot, E. M., Tarrant, T. K., & Lawrence, D. S. (2021) · Nature Reviews Chemistry · doi:10.1038/s41570-021-00326-w · Cited by 201 · see citing works

Review on Multiple Facets of Drug Resistance: A Rising Challenge in the 21st Century

Saha, M. S., & Sarkar, A. (2021) · Journal of Xenobiotics · doi:10.3390/jox11040013 · Cited by 205 · see citing works

Photodynamic and antibiotic therapy in combination against bacterial infections: efficacy, determinants, mechanisms, and future perspectives

Feng, Y., Tonon, C. C., Ashraf, S., & Hasan, T. G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113941 · Cited by 166 · see citing works

Self-assembled copper tannic acid nanoparticles: A powerful nano-bactericide by valence shift of copper

Liu, T., Ma, M., Ali, A., Liu, Q., Bai, R., Zhang, K., Guan, Y., Wang, Y., Liu, J., & Zhou, H. (2023) · Nano Today · doi:10.1016/j.nantod.2023.102071 · Cited by 126 · see citing works

In vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria

Askari, P., Namaei, M. H., Ghazvini, K., & Hosseini, M. (2021) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-021-00503-z · Cited by 122 · see citing works

Fluorescence-Based Portable Assays for Detection of Biological and Chemical Analytes

Nath, P., Mahtaba, K. R., & Ray, A. (2023) · Sensors · doi:10.3390/s23115053 · Cited by 123 · see citing works

Thiazole derivatives in medicinal chemistry: Recent advancements in synthetic strategies, structure activity relationship and pharmacological outcomes

Singh, A., Malhotra, D., Singh, K., Chadha, R., & Bedi, P. M. S. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.133479 · Cited by 108 · see citing works

Intrinsic antimicrobial resistance: Molecular biomaterials to combat microbial biofilms and bacterial persisters

Barman, S., Kurnaz, L. B., Leighton, R., Hossain, M. W., Decho, A. W., & Tang, C. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122690 · Cited by 98 · see citing works

Advances in Bioresorbable Triboelectric Nanogenerators

Kang, M., Lee, D., Hyun, I., Rubab, N., Kim, S.-H., & Kim, S. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00301 · Cited by 93 · see citing works

Ultrasound‐Driven On‐Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity

Imani, I. M., Kim, B., Xiao, X., Rubab, N., Park, B., Kim, Y., Zhao, P., Kang, M., & Kim, S. (2022) · Advanced Science · doi:10.1002/advs.202204801 · Cited by 82 · see citing works

What Do We Know about Candida auris? State of the Art, Knowledge Gaps, and Future Directions

García-Bustos, V., Cabañero-Navalón, M. D., Ruiz‐Saurí, A., Gaitán, A. C. R., Salavert, M., Tormo‐Más, M. Á., & Pemán, J. (2021) · Microorganisms · doi:10.3390/microorganisms9102177 · Cited by 82 · see citing works

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Mu, A., Klare, W. P., Baines, S. L., Pang, C. N. I., Guérillot, R., Harbison-Price, N., Keller, N., Wilksch, J. J., Nhu, N. T. K., Phan, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37200-w · Cited by 65 · see citing works

Clinical Diagnostics of Bacterial Infections and Their Resistance to Antibiotics—Current State and Whole Genome Sequencing Implementation Perspectives

Avershina, E., Khezri, A., & Ahmad, R. (2023) · Antibiotics · doi:10.3390/antibiotics12040781 · Cited by 64 · see citing works

Exploring the synthesis, properties, and potential of chitosan-functionalized metal-organic frameworks in emerging applications

Sathiyaseelan, A., Zhang, X., Lu, Y., Azeez, N. A., Zhang, L., Krishnakumar, G. S., & Wang, M. (2024) · Progress in Materials Science · doi:10.1016/j.pmatsci.2024.101387 · Cited by 62 · see citing works

PHIAF: prediction of phage-host interactions with GAN-based data augmentation and sequence-based feature fusion

Li, M., & Zhang, W. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab348 · Cited by 60 · see citing works

Green Synthesis of Copper Oxide Nanoparticles from the Leaves of Aegle marmelos and Their Antimicrobial Activity and Photocatalytic Activities

Ali, S. G., Haseen, U., JALAL, M. S., Khan, R. A., Alsalme, A., Ahmad, H., & Khan, H. M. (2023) · Molecules · doi:10.3390/molecules28227499 · Cited by 62 · see citing works

Vaccinomics to Design a Multi-Epitopes Vaccine for Acinetobacter baumannii

ud-din, M., Albutti, A., Ullah, A., Ismail, S., Ahmad, S., Naz, A., Khurram, M., Haq, M. U., Afsheen, Z., Bakri, Y. E., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095568 · Cited by 58 · see citing works

Exploring the potential of phytochemicals and nanomaterial: A boon to antimicrobial treatment

Yadav, H., Mahalvar, A., Pradhan, M., Yadav, D. K., Sahu, K. K., & Yadav, R. (2023) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2023.100151 · Cited by 62 · see citing works

Microcin MccI47 selectively inhibits enteric bacteria and reduces carbapenem-resistant Klebsiella pneumoniae colonization in vivo when administered via an engineered live biotherapeutic

Mortzfeld, B. M., Palmer, J. D., Bhattarai, S. K., Dupre, H. L., Mercado–Lubo, R., Silby, M. W., Bang, C., McCormick, B. A., & Bucci, V. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2127633 · Cited by 48 · see citing works

Lifestyle risk factors and infectious disease mortality, including COVID-19, among middle aged and older adults: Evidence from a community-based cohort study in the United Kingdom

Ahmadi, M. N., Huang, B., Eroglu, E. I., Hamer, M., & Stamatakis, E. A. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.04.022 · Cited by 48 · see citing works

A machine learning framework to predict antibiotic resistance traits and yet unknown genes underlying resistance to specific antibiotics in bacterial strains

Sunuwar, J., & Azad, R. K. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab179 · Cited by 46 · see citing works

Role of Microbiota in the Skin Colonization of Candida auris

Tharp, B., Zheng, R., Bryak, G., Litvintseva, A. P., Hayden, M. K., Chowdhary, A., & Thangamani, S. (2023) · mSphere · doi:10.1128/msphere.00623-22 · Cited by 45 · see citing works

Combinatorial enzyme therapy: A promising neoteric approach for bacterial biofilm disruption

Upadhyay, A., Pal, D., & Kumar, A. (2023) · Process Biochemistry · doi:10.1016/j.procbio.2023.02.022 · Cited by 45 · see citing works

A Pragmatic Machine Learning Model To Predict Carbapenem Resistance

McGuire, R. J., Yu, S., Payne, P., Lai, A. M., Guillamet, C. V., Kollef, M. H., & Michelson, A. P. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00063-21 · Cited by 44 · see citing works

Prevalence and resistance profile of bacteria isolated from wound infections among a group of patients in upper Egypt: a descriptive cross-sectional study

Ahmed, E. F., Rasmi, A. H., Darwish, A. M. A., & Gad, G. F. M. (2023) · BMC Research Notes · doi:10.1186/s13104-023-06379-y · Cited by 40 · see citing works

Bacterial profile and antimicrobial resistance patterns of infected diabetic foot ulcers in sub-Saharan Africa: a systematic review and meta-analysis

Wada, F. W., Mekonnen, M. F., Sawiso, E. D., Kolato, S., Woldegiorgis, L., Kera, G. K., El‐Khatib, Z., Ashuro, A. A., Biru, M., & Boltena, M. T. (2023) · Scientific Reports · doi:10.1038/s41598-023-41882-z · Cited by 40 · see citing works

Recent advances and challenges in metal-based antimicrobial materials: a review of strategies to combat antibiotic resistance

Zhu, C., Diao, Z., Yang, Y., Liao, J., Wang, C., Li, Y., Liang, Z., Xu, P., Liu, X., Zhang, Q., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03249-6 · Cited by 47 · see citing works

Carbapenem-resistant Gram-negative bacteria (CR-GNB) in ICUs: resistance genes, therapeutics, and prevention – a comprehensive review

Li, Q., Zhou, X., Yang, R., Shen, X., Li, G., Zhang, C., Li, P., Li, S., Xie, J., & Yang, Y. M. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1376513 · Cited by 45 · see citing works

Meta-analysis of Clinical Outcomes Using Ceftazidime/Avibactam, Ceftolozane/Tazobactam, and Meropenem/Vaborbactam for the Treatment of Multidrug-Resistant Gram-Negative Infections

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Bacteriophage therapy against ESKAPE bacterial pathogens: Current status, strategies, challenges, and future scope

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