The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
European guidelines for primary antifungal prophylaxis in adult haematology patients: summary of the updated recommendations from the European Conference on Infections in Leukaemia
Abstract
The European Conference on Infections in Leukaemia (ECIL) updated its guidelines on antifungal prophylaxis for adults using the grading system of IDSA. The guidelines were extended to provide recommendations for other haematological diseases besides AML and recipients of an allogeneic haematopoietic stem cell transplantation (HSCT). Posaconazole remains the drug of choice when the incidence of invasive mould diseases exceeds 8%. For patients undergoing remission-induction chemotherapy for AML and myelodysplastic syndrome (MDS), fluconazole can still offer an alternative provided it forms part of an integrated care strategy that includes screening with biomarkers and imaging. Similarly, aerosolized liposomal amphotericin B combined with fluconazole can be considered for patients at high risk of invasive mould diseases but other formulations of the polyene are discouraged. Fluconazole is still recommended as primary prophylaxis for patients at low risk of invasive mould diseases during the pre-engraftment phase of allogeneic HSCT whereas only a moderate recommendation could be made for itraconazole, posaconazole and voriconazole for patients at high risk. Posaconazole is strongly recommended for preventing invasive mould disease post-engraftment but only when graft-versus-host disease (GvHD) was accompanied by other risk factors such as its severity, use of an alternative donor or when unresponsive to standard corticosteroid therapy. The need for primary prophylaxis for other patient groups was less clear and should be defined by the estimated risk of invasive fungal disease (IFD).
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Cites
Posaconazole vs. Fluconazole or Itraconazole Prophylaxis in Patients with Neutropenia
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Posaconazole or Fluconazole for Prophylaxis in Severe Graft-versus-Host Disease
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Cited by
Breakthrough invasive fungal infections: Who is at risk?
Jenks, J. D., Cornely, O. A., Chen, S. C. ‐., Thompson, G. R., & Hoenigl, M. (2020) · Mycoses · doi:10.1111/myc.13148 · Cited by 191
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Metadata
- Authors
- Maertens, J. A., Girmenia, C., Brüggemann, R. J., Duarte, R. F., Kibbler, C. C., Ljungman, P., Racil, Z., Ribaud, P., Slavin, M. A., Cornely, O. A., Peter Donnelly, J., Cordonnier, C., (ECIL), E. C. O. I. I. L., & joint venture of the European Group for Blood and Marrow Transplantation (EBMT), T. E. O. F. R. A. T. O. C. (.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-08-01
- Volume
- 73
- Issue
- 12
- Pages
- 3221-3230
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2886222856
- Cited by
- 348
- References
- 57
- FWCI
- 23.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: European guidelines for primary antifungal prophylaxis in adult haematology patients: summary of the updated recommendations from the European Conference on Infections in Leukaemia. https://app.cochat.ai/papers/10.1093/jac/dky286
- The paper
- Maertens, J. A., Girmenia, C., Brüggemann, R. J., Duarte, R. F., Kibbler, C. C., Ljungman, P., Racil, Z., Ribaud, P., Slavin, M. A., Cornely, O. A., Peter Donnelly, J., Cordonnier, C., (ECIL), E. C. O. I. I. L., & joint venture of the European Group for Blood and Marrow Transplantation (EBMT), T. E. O. F. R. A. T. O. C. (. (2018). European guidelines for primary antifungal prophylaxis in adult haematology patients: summary of the updated recommendations from the European Conference on Infections in Leukaemia. Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/dky286
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
