The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
A fatal intoxication following the ingestion of 5-methoxy-N,N-dimethyltryptamine in an ayahuasca preparation.
Abstract
A case of a 25-year-old white male who was found dead the morning after consuming herbal extracts containing beta-carbolines and hallucinogenic tryptamines is presented. No anatomic cause of death was found at autopsy. Toxicologic analysis of the heart blood identified N,N-dimethyltryptamine (0.02 mg/L), 5-methoxy-N,N-dimethyltryptamine (1.88 mg/L), tetrahydroharmine (0.38 mg/L), harmaline (0.07 mg/L), and harmine (0.17 mg/L). All substances were extracted by a single-step n-butyl chloride extraction following alkalinization with borate buffer. Detection and quantitation was performed using liquid chromatography-electrospray mass spectrometry. The medical examiner ruled that the cause of death was hallucinogenic amine intoxication, and the manner of death was undetermined.
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“Scientific sources mention only one fatal case of ayahuasca consumption (Sklerov et al., 2005).”
From The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization (2016) · cites this paper as Sklerov et al., 2005
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Cites
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Hallucinogens and dissociative agents naturally growing in the United States
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“Caapi alkaloids can result in toxic effects, culminating in possible death (Sklerov et al., 2005).”
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“However, a number of the leading scientists engaged in ayahuasca research seriously questioned the original reporting of the incident by Sklerov et al. (2005), the source quoted here, and published a rebuttal in the same journal indicating that the report “is misleading as to the nature and…”
BackgroundOssato, A., Canazza, I., & Marti, M. (2015) · Institutional Research Information System University of Ferrara (University of Ferrara)
Tavares, L. S. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.60.2014.tde-30102014-162441
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Melo, W. (2014) · RIUnB Institutional Repository (University of Brasília) · doi:10.26512/2014.11.d.17573
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“[19] While in Ayahuasca and its analogue brews the concentration of is only low concentrations of 5-MeO-DMT, much higher concentrations can be found in Anadenanthera peregrina (used as yopo or cohoba snuff) and in Virola theiodora.”
BackgroundO’Connor, A. D., & Mills, K. C. (2015) · Springer eBooks · doi:10.1007/978-3-319-20790-2_28-1
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Metadata
- Authors
- Sklerov, J., Levine, B., Moore, K. A., King, T., & Fowler, D.
- Affiliations
- State of Maryland (US)
- Corresponding author
- Levine, Barry
- ORCID
- Fowler, David
- Venue
- Journal of Analytical Toxicology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-11-01
- Volume
- 29
- Issue
- 8
- Pages
- 838-841
- ISSN
- 0146-4760 (ISSN-L)
- 1945-2403
- OpenAlex
- W2159917347
- Cited by
- 144
- References
- 15
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 8 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 9 · 2013: 6 · 2012: 4
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Analytical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and bioactivity of alkaloids
- Keywords
- 5-MeO-DMT, ayahuasca, β-carbolines, tetrahydroharmine, harmaline, harmine, fatal poisoning, death investigation, postmortem toxicology
- MeSH terms
- Adult, Chromatography, Liquid, Humans, Male, Methoxydimethyltryptamines, Mass Spectrometry, Fatal Outcome, Banisteriopsis
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