The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Correlations Between Phthalate Metabolites in Urine, Serum, and Seminal Plasma from Young Danish Men Determined by Isotope Dilution Liquid Chromatography Tandem Mass Spectrometry
Abstract
Phthalates are suspected of endocrine disrupting effects. We aimed to develop an analytical method for simultaneous determination of several phthalate metabolites in human urine, serum, and seminal plasma and to study correlations between levels of metabolites in these matrices. Thirteen metabolites were determined in samples from 60 young Danish men. Metabolites of common di-ester phthalates were detected in most urine samples. Summed di-(2-ethylhexyl) phthalate (DEHP) metabolites were excreted in urine in the highest amount (median = 91.1 ng/mL), followed by monoethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), mono-benzyl phthalate (MBzP), and finally summed di-isononyl phthalate (DiNP) metabolites. All these metabolite levels correlated significantly, indicating that when a participant was highly exposed to one phthalate he was also highly exposed to other phthalates. Several metabolites were also detectable in serum and in seminal plasma, although in much lower levels. Significant correlations between MEP and MiBP levels in serum and urine were observed, showing that serum levels could be used as biomarkers of human exposure. For DEHP and DiNP metabolites, correlations between urine and serum levels were only observed for mono(2-ethyl-5-carboxypentyl) phthalate (MECPP) and mono-(4-methyl-7-carboxyheptyl) phthalate (MCiOP), indicating that these secondary carboxylated metabolites were better serum markers than primary metabolites [mono(2-ethylhexyl) phthalate (MEHP) and mono-iso-nonyl phthalate (MiNP)]. In seminal plasma, only MEP levels correlated significantly to levels in urine and in serum.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, when only serum was available for analysis, MEP and MiBP representing low molecular weight phthalates, and MECPP and MCiOP representing high molecular weight phthalates, have been used as indicators of phthalate exposure [77].”
From A Review of Biomonitoring of Phthalate Exposures (2019) · cites this paper as [77]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The mean concentrations of MEP, MBP, and DEHP metabolites were one to two orders of magnitude lower in serum (MEP: 4.2, MBP: 0.4, and DEHP: 7.6 µg/L) and seminal plasma (1.0, 0.8, and 0.6 µg/L) than in urine (326, 42.5, and 115 µg/L).”
From A Review of Biomonitoring of Phthalate Exposures (2019) · cites this paper as [77]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?
Sharpe, R. M., & Skakkebæk, N. E. (1993) · The Lancet · doi:10.1016/0140-6736(93)90953-e · Cited by 1,849
Decrease in anogenital distance among male infants with prenatal phthalate exposure
Swan, S. H., Main, K. M., Liu, F., Stewart, S. L., Kruse, R. L., Calafat, A. M., Mao, C. S., Redmon, J. B., Ternand, C. L., Sullivan, S., et al. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8100 · Cited by 1,586
Gray, L. E. (2000) · Toxicological Sciences · doi:10.1093/toxsci/58.2.350 · Cited by 1,084
What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?
Wormuth, M., Scheringer, M., Vollenweider, M., & Hungerbühler, K. (2006) · Risk Analysis · doi:10.1111/j.1539-6924.2006.00770.x · Cited by 1,025
Main, K. M., Mortensen, G. K., Kaleva, M. M., Boisen, K. A., Damgaard, I. N., Chellakooty, M., Schmidt, I. M., Suomi, A.-M., Virtanen, H. E., Petersen, J. H., et al. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8075 · Cited by 696
Self-citationStahlhut, R. W., van Wijngaarden, E., Dye, T. D., Cook, S., & Swan, S. H. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9882 · Cited by 646
Foster, P. M. D. (2006) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00563.x · Cited by 579
Fisher, J. S. (2003) · Human Reproduction · doi:10.1093/humrep/deg273 · Cited by 550
Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects
Sharpe, R. M., & Skakkebæk, N. E. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.12.026 · Cited by 452
Hauser, R., Meeker, J. D., Duty, S., Silva, M. J., & Calafat, A. M. (2006) · Epidemiology · doi:10.1097/01.ede.0000235996.89953.d7 · Cited by 424
Cited by
Sorted by citations
Items 101–200 of 203
Analytical Methodologies for the Assessment of Phthalate Exposure in Humans
Tsochatzis, E., Tzimou-Tsitouridou, R. D., & Gika, H. (2016) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2016.1273754 · Cited by 36
Chang, J.-W., Liao, K., Huang, C.-Y., Huang, H.-B., Chang, W., Jaakkola, J. J. K., Hsu, C.-C., Chen, P.-C., & Huang, P. (2019) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2019.10.009 · Cited by 34
Analytical methods for selected emerging contaminants in human matrices—a review
Dirtu, A. C., den Eede, N. V., Malarvannan, G., Ionas, A. C., & Covaci, A. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6053-0 · Cited by 34
Muerköster, A.-P., Frederiksen, H. W., Juul, A., Andersson, A., Jensen, R. C., Glintborg, D., Kyhl, H. B., Andersen, M., Timmermann, C. A. G., & Jensen, T. K. (2020) · Environment International · doi:10.1016/j.envint.2020.106025 · Cited by 33
Self-citationMiura, R., Araki, A., Ishihara, T., Miyake, K., Miyashita, C., Nakajima, T., Kobayashi, S., Ishizuka, M., Kubota, T., & Kishi, R. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.147035 · Cited by 33
Jornet‐Martínez, N., Antón-Soriano, C., & Campíns-Falcó, P. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.05.124 · Cited by 33
Hsu, J., Chang, C., Ho, W.-Y., & Liao, P. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.339610 · Cited by 33
Effects of mono(2-ethylhexyl)phthalate on cytoplasmic maturation of oocytes – The bovine model
Kalo, D., & Roth, Z. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.04.007 · Cited by 31
Fu, X., He, J., Zheng, D., Yang, X., Wang, P., Tuo, F., Wang, L., Li, S., Yu, J., & Yu, J. (2021) · Toxicology · doi:10.1016/j.tox.2021.153011 · Cited by 30
Sánchez‐Resino, E., Marquès, M., Gutiérrez-Martín, D., Restrepo-Montes, E., Martínez, M. Á., Salas‐Huetos, A., Babió, N., Salas‐Salvadó, J., Gil‐Solsona, R., & Gago-Ferrero, P. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c04347 · Cited by 28
Urinary phthalate metabolite concentrations in girls with premature thelarche
Durmaz, E., Erkekoğlu, P., Aşçı, A., Akçurin, S., Bircan, İ., & Giray, B. (2018) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.03.010 · Cited by 29
Klopčič, I., Kolšek, K., & Dolenc, M. S. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.11.019 · Cited by 28
Zhang, B., Li, H., Zheng, X., Teng, Y., Liu, Y., & Lin, J. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.10.034 · Cited by 28
Kim, D., Park, C. G., Kim, S. H., & Kim, Y. J. (2019) · Molecules · doi:10.3390/molecules24081558 · Cited by 28
Berman, Y. E., Doherty, D. A., Main, K. M., Frederiksen, H. W., Hickey, M., Keelan, J. A., Newnham, J. P., & Hart, R. J. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18094725 · Cited by 28
Self-citationWang, Y., Liu, C., Chen, Y., Chen, H., Yang, P., Wang, P., Huang, L.-L., Ai, S.-H., Duan, P., Pan, A., et al. (2017) · Environmental Research · doi:10.1016/j.envres.2017.11.027 · Cited by 28
Henriksen, L. S., Mathiesen, B. K., Assens, M., Krause, M., Skakkebæk, N. E., Juul, A., Andersson, A., Hart, R. J., Newnham, J. P., Keelan, J. A., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109231 · Cited by 28
Self-citationPhthalates: Exposure and Health Effects
Tsatsakis, A. M., Katsikantami, I., Kalantzi, O., Sevim, Ç., Tsarouhas, K., Sarigiannis, D. A., Tzatzarakis, M. N., & Rizos, A. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-409548-9.11434-4 · Cited by 28
Dima, A. P., Santis, L. D., Verlengia, C., Lombardo, F. P., Lenzi, A., Mazzarino, M., Botrè, F., & Paoli, D. (2020) · Clinical mass spectrometry · doi:10.1016/j.clinms.2020.10.002 · Cited by 28
Human Biomonitoring of Select Ingredients in Cosmetics
Karthikraj, R., & Kannan, K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-444-63508-2.00015-1 · Cited by 27
Varik, I., Zou, R., Bellavia, A., Rosenberg, K., Sjunnesson, Y. C. B., Hallberg, I., Holte, J., Lenters, V. C., van Duursen, M. B. M., Pedersen, M., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.108960 · Cited by 26
Teitelbaum, S. L., Li, Q., Lambertini, L., Belpoggi, F., Manservisi, F., Falcioni, L., Bua, L., Silva, M. J., Ye, X., Calafat, A. M., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1409586 · Cited by 26
Joensen, U. N., Jørgensen, N., Meldgaard, M., Frederiksen, H. W., Andersson, A., Menné, T., Johansen, J. D., Carlsen, B. C., Stender, S., Szecsi, P. B., et al. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1306720 · Cited by 25
Self-citationvan der Meer, T. P., van Faassen, M. H. J. R., Frederiksen, H. W., van Beek, A. P., Wolffenbuttel, B. H. R., Kema, I. P., & van Vliet‐Ostaptchouk, J. V. (2019) · Journal of Analytical Toxicology · doi:10.1093/jat/bkz027 · Cited by 25
Self-citationLevels of endocrine-disrupting chemicals are associated with changes in the peri-pubertal epigenome
Almstrup, K., Frederiksen, H. W., Andersson, A., & Juul, A. (2020) · Endocrine Connections · doi:10.1530/ec-20-0286 · Cited by 25
Self-citationHsu, J.-Y., Ho, H.-H., & Liao, P. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.09.025 · Cited by 25
Sun, X., Chen, W., Weng, S., Pan, T., Hu, X.-N., Wang, F., Xia, T., Chen, H., & Luo, T. (2020) · Reproduction Fertility and Development · doi:10.1071/rd19164 · Cited by 24
SHEIKH, I. A., & Beg, M. A. (2017) · Journal of Applied Toxicology · doi:10.1002/jat.3497 · Cited by 24
Kransler, K. M., Bachman, A. N., & McKee, R. H. (2012) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2012.01.001 · Cited by 23
Maternal phthalate exposure during pregnancy and testis function of young adult sons
Henriksen, L. S., Frederiksen, H. W., Jørgensen, N., Juul, A., Skakkebæk, N. E., Toppari, J., Petersen, J. H., & Main, K. M. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.161914 · Cited by 22
Self-citationMolbert, N., Alliot, F., Santos, R., Chevreuil, M., Mouchel, J., & Goutte, A. (2019) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4500 · Cited by 22
Accuracy Investigation of Phthalate Metabolite Standards
Langlois, É., LeBlanc, A., Simard, Y., & Thellen, C. (2012) · Journal of Analytical Toxicology · doi:10.1093/jat/bks016 · Cited by 21
Sales, L. B., van Esterik, J. C. J., Hodemaekers, H. M., Lamoree, M. H., Hamers, T., van der Ven, L. T. M., & Legler, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00684 · Cited by 20
Pérez-Díaz, C., Pérez-Carrascosa, F. M., Gallego, B. R., Villegas-Arana, E., Armendariz, A. J., Galindo-Ángel, J., Frederiksen, H. W., León, J., Requena, P., & Arrebola, J. P. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c07150 · Cited by 20
Self-citationExposure to environmental doses of DEHP causes phenotypes of polycystic ovary syndrome
Wang, S., Xu, K., Du, W., Gao, X. F., Ma, P., Yang, X., & Chen, M. (2024) · Toxicology · doi:10.1016/j.tox.2024.153952 · Cited by 20
Karabulut, G., & Barlas, N. (2021) · Toxicology Research · doi:10.1093/toxres/tfab045 · Cited by 20
Are nails a valuable non-invasive alternative for estimating human exposure to phthalate esters?
Alves, A. C. H., Covaci, A., & Voorspoels, S. (2016) · Environmental Research · doi:10.1016/j.envres.2016.07.023 · Cited by 20
Alves, A. C. H., Koppen, G., Vanermen, G., Covaci, A., & Voorspoels, S. (2016) · Journal of Chromatography B · doi:10.1016/j.jchromb.2016.09.039 · Cited by 20
Hadrup, N., Svingen, T., Mandrup, K. R., Skov, K., Pedersen, M., Frederiksen, H. W., Frandsen, H. L., & Vinggaard, A. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162027 · Cited by 20
Self-citationSumner, R. N., Byers, A. S., Zhang, Z., Agerholm, J. S., Lindh, L., England, G., & Lea, R. G. (2021) · Scientific Reports · doi:10.1038/s41598-021-86805-y · Cited by 20
Qian, B., Zheng, Z.-X., Yang, L., Wang, C., Lin, Y., & Lin, Z. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114571 · Cited by 19
Vilmand, M., Beck, I. H., Bilenberg, N., Andersson, A., Juul, A., Schoeters, G. E. R., Boye, H., Frederiksen, H. W., & Jensen, T. K. (2023) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2023.107161 · Cited by 19
Self-citationHansen, J. F., Brorson, M. M., Boas, M., Frederiksen, H. W., Nielsen, C. H., Lindström, E. S., Hofman-Bang, J., Hartoft‐Nielsen, M., Frisch, T., Main, K. M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151192 · Cited by 19
Self-citationYuan, G., Zeng, Y., Hu, G., Liu, Y., Wei, L., Liu, P., Liu, G., & Cheng, J. (2021) · Environment International · doi:10.1016/j.envint.2021.106459 · Cited by 19
Human Exposure and Health Risks to Emerging Organic Contaminants
Covaci, A., Geens, T., Roosens, L., Ali, N., den Eede, N. V., Ionas, A. C., Malarvannan, G., & Dirtu, A. C. (2011) · The handbook of environmental chemistry · doi:10.1007/698_2011_126 · Cited by 18
Evans, S. F., Raymond, S., Sethuram, S., Barrett, E. S., Bush, N. R., Nguyen, R. H. N., Sathyanarayana, S., & Swan, S. H. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110264 · Cited by 18
Oluwayiose, O. A., Houle, E., Whitcomb, B. W., Suvorov, A., Rahil, T., Sites, C. K., Krawetz, S. A., Visconti, P. E., & Pilsner, J. R. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121529 · Cited by 19
Andreasen, S. M., Frederiksen, H. W., Bilenberg, N., Andersson, A., Juul, A., Kyhl, H. B., & Jensen, T. K. (2023) · Environment International · doi:10.1016/j.envint.2023.108244 · Cited by 19
Self-citationMørck, T. A., Nielsen, F., Nielsen, J. K. S., Jensen, J., Hansen, P. W., Hansen, A. K., Christoffersen, L. A. N., Siersma, V., Larsen, I., Hohlmann, L. K., et al. (2014) · Environmental Research · doi:10.1016/j.envres.2014.07.028 · Cited by 18
Self-citationHwa, H., Peng, F., Ting, T., Chen, H., Chan, H.-Y., Yang, D., Chen, P., Kuo, Y.-N., & Chen, P.-S. (2022) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5280 · Cited by 18
Xia, Y., Chen, J., Ma, T., Meng, X., Han, X., & Li, D. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.154437 · Cited by 17
Berman, Y. E., Doherty, D. A., Main, K. M., Frederiksen, H. W., Keelan, J. A., Newnham, J. P., & Hart, R. J. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110313 · Cited by 17
Self-citationSreejith, M. V., Aradhana, K. S., Varsha, M., Cyrus, M. K., Aravindakumar, C. T., & Aravind, U. K. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.147066 · Cited by 17
Lee, S., Lee, K. M., Han, S. M., Lee, H.-J., Sung, C., Min, H., Im, H., Han, S. B., Cha, S., & Lee, J. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113053 · Cited by 16
Golestanzadeh, M., Goodarzi-Khoigani, M., Daniali, S. S., Ebrahimpour, K., Zarean, E., Yazdi, M., Basirat, Z., & Kelishadi, R. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-20839-1 · Cited by 16
Tan, Y., Guo, Z., Yao, H., Liu, H., Fu, Y., Luo, Y., He, R., Liu, Y., Li, P., Nie, L., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116216 · Cited by 15
Guo, X., Sheng, Y., Liu, B., Tang, P., Liu, R., Wu, L., Chen, J., Huang, D., Liu, S., & Qiu, X. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-19919-z · Cited by 15
Berman, Y. E., Doherty, D. A., Mori, T. A., Beilin, L. J., Ayonrinde, O. T., Adams, L. A., Huang, R., Olynyk, J. K., Keelan, J. A., Newnham, J. P., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192215244 · Cited by 14
Lee, K.-M., Kho, Y., Kim, P., Park, S.-H., & Lee, J.-H. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-9068-4 · Cited by 14
Al‐Saleh, I., Coşkun, S., Al-Doush, I., Al-Rajudi, T., Abduljabbar, M., Al-Rouqi, R., & Hassan, S. S. M. (2019) · Environmental Monitoring and Assessment · doi:10.1007/s10661-019-7474-4 · Cited by 14
Environmental Pollution to Blame for Depressive Disorder?
Mendoza, M. S., Arreola, M. I. P., Pavón, L., Becerril‐Villanueva, E., Castro, K. E. N., Amador-Muñóz, O., & Morales‐Montor, J. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031737 · Cited by 13
Novillo-Sanjuan, O., Sait, S. T. L., González, S. V., Tomás, J., Raga, J. A., & Asimakopoulos, A. G. (2023) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2023.08.003 · Cited by 13
Associations of serum phthalate metabolites with thyroid hormones in GraMo cohort, Southern Spain
Donat‐Vargas, C., Pérez-Carrascosa, F. M., Gómez-Peña, C., Mustieles, V., Salcedo‐Bellido, I., Frederiksen, H. W., Åkesson, A., & Arrebola, J. P. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117606 · Cited by 13
Self-citationTeng, M., Sun, J., Zhao, L., Li, Y., Zhang, Z., Zhu, W., Zhang, Y., Xu, F., Xing, S., Zhao, X., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.108851 · Cited by 12
Wei, Y., Hong, Y., Yang, L., Wang, J., Zhao, T., Zheng, X., Kang, L., Chen, J., Han, L., Long, C., et al. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113780 · Cited by 11
Bhurke, A., Dávila, J., Flaws, J. A., Bagchi, M. K., & Bagchi, I. C. (2023) · Reproductive Toxicology · doi:10.1016/j.reprotox.2023.108446 · Cited by 11
Cai, F., Tang, B., Zheng, J., Yan, X., Ding, X.-F., Liao, Q., Luo, X., Ren, M., Yu, Y., & Mai, B. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c11032 · Cited by 10
Yoshida, T. (2016) · Biomedical Chromatography · doi:10.1002/bmc.3910 · Cited by 10
Goerdeler, C., Engelmann, B., Aldehoff, A. S., Schaffert, A., Blüher, M., Heiker, J. T., Wabitsch, M., Schubert, K. A., Rolle-Kampczyk, U. E., & von Bergen�, M. (2024) · Environmental Research · doi:10.1016/j.envres.2024.118847 · Cited by 8
Luo, Y., He, R., Zhang, L., Qin, P., Bai, Z., Peng, R., He, H., & Tan, L. (2025) · Talanta · doi:10.1016/j.talanta.2025.127740 · Cited by 7
CCDB: A database for exploring inter-chemical correlations in metabolomics and exposomics datasets
Barupal, D. K., Mahajan, P., Baygi, . F., Wright, R. O., Arora, M., & Teitelbaum, S. L. (2022) · Environment International · doi:10.1016/j.envint.2022.107240 · Cited by 7
Prenatal Exposure to Di(2-ethylhexyl) phthalate and Subsequent Infant and Child Health Effects
Nakajima, T., Hayashi, Y., & Ito, Y. (2015) · Food Safety · doi:10.14252/foodsafetyfscj.2015011 · Cited by 7
Assens, M., Frederiksen, H. W., Pedersen, A. T., Petersen, J. H., Andersson, A., Sundberg, K., Jensen, L. N., Curtin, P. C. P., Skakkebæk, N. E., Swan, S. H., et al. (2024) · Human Reproduction · doi:10.1093/humrep/deae229 · Cited by 7
Self-citationIn Vitro Toxicity of a DEHP and Cadmium Mixture on Sheep Cumulus–Oocyte Complexes
Mastrorocco, A., Temerario, L., Vurchio, V., Cotecchia, S., Martino, N. A., & Dell’Aquila, M. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010005 · Cited by 5
Roeder, R. F. S., Borte, W. O. M., & von Bergen, I. L. M. (2015) · Journal of Chromatography & Separation Techniques · doi:10.4172/2157-7064.1000290 · Cited by 5
Dibutyl phthalate exposure suppresses Wnt/β-catenin pathway and induces oxidative damage in placenta
Xiong, S., Tao, L., Dai, L., Liao, D., Zhou, Y., & Shen, X. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118341 · Cited by 4
Prenatal and early childhood exposure to phthalates and neurodevelopment in 42 months old children
Cohen-Eliraz, L., Ornoy, A., Ein‐Mor, E., Bar-Nitsan, M., Calderon‐Margalit, R., & Peleg, T. P. (2025) · NeuroToxicology · doi:10.1016/j.neuro.2025.07.007 · Cited by 4
Runkel, A. A., Rekar, Ž., Kosirnik, N., Mazej, D., Horvat, M., Tratnik, J. S., & Kosjek, T. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.119698 · Cited by 4
Ashley‐Martin, J., Hammond, J., & Vélez, M. P. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108578 · Cited by 4
Exploring noninvasive matrices for assessing long-term exposure to phthalates: a scoping review
Chen, L.-W., Chen, X., Mo, H.-Y., Shan, C.-H., Zhu, R.-P., Gao, H., & Tao, F. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1411588 · Cited by 3
EXPOSOME RESEARCH: DEFINITION, SCOPE AND THE NEED FOR MULTIDISCIPLINARY RESEARCH
Negrei, C. (2023) · FARMACIA · doi:10.31925/farmacia.2023.4.1 · Cited by 3
Dibutyl phthalate disrupts glycogen synthase kinase 3α essential for sperm motility
Park, S. H., & Gye, M. C. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.115977 · Cited by 3
Harray, A. J., Herrmann, S., Papendorf, H., Miller, C., Vermeersch, A., Smith, T., & Lucas, M. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1443792 · Cited by 3
Chen, Y., Weng, X., Yu, H., Yin, J., Liu, S., Zhu, Q., Hu, L., Liao, C., & Jiang, G. (2024) · Journal of Environmental Sciences · doi:10.1016/j.jes.2024.10.026 · Cited by 3
Gómara, B., Lebrón‐Aguilar, R., González, M. J., & Quintanilla-López, J. E. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2015.10.069 · Cited by 3
Tartrate inhibition of prostatic acid phosphatase improves seminal fluid metabolite stability
Roberts, M. J., Hattwell, J. P. N., Chow, C. W. K., Lavin, M. F., Pierens, G. K., Gardiner, R. A., & Schirra, H. J. (2016) · Metabolomics · doi:10.1007/s11306-016-1102-x · Cited by 3
Lin, Y., Wuputra, K., Kato, K., Ku, C., Saito, S., Noguchi, M., Nakamura, Y., Hsiao, M., Lin, C., Wu, D., et al. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123722 · Cited by 2
Mental Health Disorders Following Exposure to Endocrine Disruptor Chemicals
Ehsanifar, M., Gholami, A., & Esmaeili, A. (2025) · OBM Neurobiology · doi:10.21926/obm.neurobiol.2502285 · Cited by 2
Stepanović, K., Vuković, B., Milanović, M., Milosevic, N. P., Bosić-Živanović, D., Stojadinović, A., Tomić-Naglić, D., Lepić, S., Milić, N., & Medic‐Stojanoska, M. (2020) · Vojnosanitetski pregled · doi:10.2298/vsp200220093s · Cited by 2
Protection Studies by Antioxidants Using Single Cell Gel Electrophoresis (Comet Assay)
Erkekoglu, P. (2012) · InTech eBooks · doi:10.5772/36819 · Cited by 2
Migration of phthalates on culture plates – an important challenge to consider forin vitrostudies
Hansen, J. F., Boas, M., Brorson, M. M., Frederiksen, H. W., Hartoft‐Nielsen, M., Rasmussen, Å. K., Main, K. M., & Feldt‐Rasmussen, U. (2016) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2015.1110857 · Cited by 2
Self-citationDetermination of Serum Methylparaben Concentrations of Bangladeshi Breast Cancer Patients by RP-HPLC
Afrin, S., Simol, H. A., Sultana, G. N. N., Islam, M. S., Haque, P., Khan, M. N., & Rahman, M. M. (2017) · Analytical Chemistry Letters · doi:10.1080/22297928.2017.1400400 · Cited by 1
Czernych, R., Chraniuk, M., & Wolska, L. (2023) · Polish Journal of Environmental Studies · doi:10.15244/pjoes/155147 · Cited by 1
Exposure Assessment of Emerging Chemicals and Novel Screening Strategies
Zhu, Q., & Dai, H. (2019) · Springer eBooks · doi:10.1007/978-981-32-9535-3_2 · Cited by 1
COMPARATIVE SERUM PHTHALATE CONCENTRATIONS IN FERTILE VERSUS INFERTILE MEN AND WOMEN IN SASKATCHEWAN
Roy, S. (2014) · University Library - University of Saskatchewan (University of Saskatchewan)
Jayaseelan, K., & Lakshmi, K. S. (2017) · Journal of Young Pharmacists · doi:10.5530/jyp.2017.9.35
Exposure, bioactivation and metabolic toxicity of bisphenol a diglycidyl ether
Liu, M. (2020) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/143805
Barupal, D. K., Mahajan, P., Baygi, . F., Wright, R. O., Arora, M., & Teitelbaum, S. L. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.01.478739
Xiong, F., Zhou, B., Wu, N.-X., Deng, L., Xie, J., Li, X.-J., Wang, Y., Zeng, Q., & Yang, P. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.3987971
Peng, B. (2022) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/160287
Metadata
- Authors
- Frederiksen, H., Jorgensen, N., & Andersson, A.-M.
- Affiliations
- Copenhagen University Hospital (DK)
- Corresponding author
- Frederiksen, H.
- Venue
- Journal of Analytical Toxicology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09-01
- Volume
- 34
- Issue
- 7
- Pages
- 400-410
- ISSN
- 0146-4760 (ISSN-L)
- 1945-2403
- OpenAlex
- W2150227280
- Cited by
- 204
- References
- 35
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 15 · 2023: 12 · 2022: 17 · 2021: 11 · 2020: 19 · 2019: 13 · 2018: 18 · 2017: 12 · 2016: 16 · 2015: 21 · 2014: 17 · 2013: 9 · 2012: 13
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Analytical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Funders
- Velux Fonden
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- phthalate metabolites, DEHP metabolites, monoethyl phthalate, mono-n-butyl phthalate, monobenzyl phthalate, diisononyl phthalate, urinary biomarkers, serum biomarkers, seminal plasma, exposure assessment, endocrine disruptors
- MeSH terms
- Chromatography, Liquid, Denmark, Environmental Monitoring, Humans, Male, Phthalic Acids, Plasticizers, Semen, Biomarkers, Tandem Mass Spectrometry, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review