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Postsynaptic density proteins and their involvement in neurodevelopmental disorders
Abstract
Synaptic connections are essential for neural circuits in order to convey brain functions. The postsynaptic density (PSD) is a huge protein complex associated with postsynaptic membranes of excitatory synapses. In mammals, the PSD is composed of more than 1,000 proteins including receptors, scaffold proteins, signalling enzymes and cytoskeletal proteins. PSD proteins are crucial for synaptic transmission and plasticity. Proteomic studies have revealed the composition of PSD proteins in various species, brain regions and specific physiological conditions. Abnormalities with PSD proteins are linked to various neuropsychiatric diseases including neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. Here, we review different kinds of proteomic studies of the PSD and the involvement of PSD proteins in physiological and pathological conditions.
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“In the early 2000s, major advances occurred with the discovery that the synapse proteome is complex, comprising over a thousand conserved proteins, particularly within excitatory synapses [9].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [9]
In the citing paper
“The PSD is characterized by high molecular complexity, comprising over a thousand different proteins in mammals [9].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [9]
In the citing paper
“The integrity and proper function of PSD proteins are paramount, as abnormalities have been strongly linked to various neuropsychiatric diseases, including autism spectrum disorder and schizophrenia [9].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [9]
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“Synaptic dysfunction has been observed at several levels including: genetic alterations (92–94); aberrant proteins (95) and their translation (25,96–98); molecular signalling pathways (99–101); spine morphology (102); aberrant synaptic plasticity (103–105); neurocircuitry and connectivity (106).”
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“(f) Venn diagram represents the number of overlapped and unique genes as shown in Figure 3e as the synapse (Grant, 2019), synaptic vesicles (Burré & Volknandt, 2007), and the post- synaptic density (PSD) fraction (Kaizuka & Takumi, 2018).”
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“PSD-95 is a plastic protein located in the postsynaptic membrane that mainly maintains synaptic development and synaptic structural plasticity and participates in synaptic transmission (38).”
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“PSD-95 in the spinal cord has been implicated in the pathophysiology of neuropathic pain [24], while PSD-95 in the cortex has been shown to be crucial for learning, memory, and neuroplasticity [23].”
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“The dysregulation of these processes is linked to abnormal synaptic plasticity mechanisms (like impaired dendritic spine maturation and reduced LTP) associated with psychiatric disorders, including neurodevelopmental disorders and, particularly, schizophrenia [208–210].”
Accelerating therapeutic development and clinical trial readiness for STXBP1 and SYNGAP1 disorders
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Carbonell, A. U., Freire‐Cobo, C., Deyneko, I. V., Dobariya, S., Erdjument‐Bromage, H., Clipperton‐Allen, A. E., Page, D. T., Neubert, T. A., & Jordan, B. A. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1152562 · Cited by 19
“AIDA-1 is a core protein of the postsynaptic density and interacts with PSD95 in a complex that contains other factors associated with neurodevelopmental disorders, including Grin2b, Syngap1, and Nlgn (Kaizuka and Takumi, 2018; Carbonell et al., 2019).”
BackgroundZhao, L., Yi, R., Liu, S.-X.-D.-L., Chi, Y., Tan, S.-Z., Dong, J., Wang, H., Zhang, J., Wang, H.-Y., Xu, X.-P., et al. (2022) · bioRxiv · doi:10.1101/2022.04.04.487008 · Cited by 15
“PSD-95, containing 3 PDZ domains, an SH3 domain and a guanylate kinase region, belongs to the membrane-associated guanylate kinase family [27, 28].”
BackgroundFocus on Causality in ESC/iPSC-Based Modeling of Psychiatric Disorders
Hoffmann, A., Ziller, M. J., & Spengler, D. (2020) · Cells · doi:10.3390/cells9020366 · Cited by 17
“This structure contains a network of scaffolding proteins among which SHANK3 functions as a master scaffolder by forming large sheets that may provide the platform for the assembly of the entire PSD complex [69].”
BackgroundCinar, H., Oliva, R., Lin, Y., Chen, X., Zhang, M., Chan, H. S., & Winter, R. (2020) · Chemistry - A European Journal · doi:10.1002/chem.201905269 · Cited by 23
Zhang, J., Zhang, Z., Zhang, J., Zheng, Z., Yao, Z., Qu, S., & Huang, Y. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/3424698 · Cited by 13
“These proteins are crucial for synaptic transmission and plasticity [41].”
Chronic Methylphenidate Effects on Brain Gene Expression: An Exploratory Review
Klein, S., Blum, K., Gold, M. S., & Thanos, P. K. (2024) · Psychology Research and Behavior Management · doi:10.2147/prbm.s445719 · Cited by 15
“29,85 MP studies indicate a general upregulation of the PSD proteins, due to an increase in neurotransmitters within the synapses.”
The role of NMDARs in the anesthetic and antidepressant effects of ketamine
Zhou, L., & Duan, J. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14464 · Cited by 17
“150 153 The postsynaptic density consisted of synaptic NMDARs and thousands of proteins, 154 and exhibited as a dense lamina under an electron microscope.”
BackgroundLigand gated receptor interactions: A key to the power of neuronal networks
Neff, R. A., Kambara, K., & Bertrand, D. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114653 · Cited by 16
Farahani, M., Rezaei–Tavirani, M., Zali, A., & Azodi, M. Z. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00998-w · Cited by 13
Yates, J. R. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111107 · Cited by 15
Xie, M.-J., Iwata, K., Ishikawa, Y., Nomura, Y., Tani, T., Murata, K., Fukazawa, Y., & Matsuzaki, H. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.748627 · Cited by 15
“PSD is composed of proteins, including neurotransmitter receptors, cell adhesion molecules, scaffold proteins, signaling enzymes, cytoskeleton proteins, and membrane trafficking proteins (Sheng and Hoogenraad, 2007; Kaizuka and Takumi, 2018).”
BackgroundInterrogating Synaptic Architecture: Approaches for Labeling Organelles and Cytoskeleton Components
Reshetniak, S., & Rizzoli, S. O. (2019) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2019.00023 · Cited by 17
Autism spectrum disorder and various mechanisms behind it
Rajabi, P., Noori, A. S., & Sargolzaei, J. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173887 · Cited by 17
Jiang, J., Wilkinson, B., Flores, I., Hartel, N. G., Mihaylov, S. R., Clementel, V. A., Flynn, H. R., Alkuraya, F., Ultanir, S. K., Graham, N. A., et al. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1359154 · Cited by 12
“On many occasions, highly penetrant truncation mutations are causative of developmental delay or IDD (Li et al., 2017; Kaizuka and Takumi, 2018; Sorokina et al., 2021), and single-nucleotide variants (SNVs) or variants of uncertain significance (VUS) described in complex brain disorders including…”
BackgroundPlaza‐Díaz, J., Radar, A. M., Baig, A. T., Leyba, M. F., Costabel, M. M., Zavala-Crichton, J. P., Sanchez‐Martinez, J., MacKenzie, A., & Solis‐Urra, P. (2022) · Children · doi:10.3390/children9121834 · Cited by 12
Is PSD-95 entangled in the side effects of antidepressants?
Stachowicz, K. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105391 · Cited by 12
Strużyńska, L., Dąbrowska‐Bouta, B., & Sułkowski, G. (2022) · Nanotoxicology · doi:10.1080/17435390.2022.2105172 · Cited by 12
“The postsynaptic region of excitatory synapses, referred to as postsynaptic density (PSD), is composed of an array of proteins among which the glutamate N-methylD-aspartate receptor (NMDAR) is anchored to form a multiprotein complex (Kaizuka and Takumi 2018).”
BackgroundComparison of Multiscale Imaging Methods for Brain Research
Tröger, J., Hoischen, C., Perner, B., Monajembashi, S., Barbotin, A., Löschberger, A., Eggeling, C., Kessels, M. M., Qualmann, B., & Hemmerich, P. H. (2020) · Cells · doi:10.3390/cells9061377 · Cited by 12
“In the case of excitatory glutamatergic synapses, this postsynaptic compartment is often located in dendritic spines protruding maximally 1–3 μm from the dendrite [13,16,17].”
BackgroundAlteration of synaptic protein composition during developmental synapse maturation
Kaizuka, T., & Takumi, T. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16304 · Cited by 13
“The GluN2B subunit of the NMDAR binds to PSD-95, whereas the AMPAR associates with PSD-95 through transmembrane AMPAR regulatory proteins (TARPs), including stargazin (Kaizuka & Takumi, 2018; Zhu et al., 2016).”
BackgroundSelf-citationIasevoli, F., Buonaguro, E. F., Avagliano, C., Barone, A., Eramo, A., Vellucci, L., & de Bartolomeis, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155555 · Cited by 10
“Notably, antipsychotic agents have been found to modulate the expression of glutamatergic genes of the postsynaptic density (PSD), an electron-dense thickening at the surface of the glutamatergic postsynaptic membrane [5–7], actively involved in behavioral disorders’ molecular pathophysiology [8,9].”
BackgroundDąbrowska‐Bouta, B., Sułkowski, G., Sałek, M., Frontczak‐Baniewicz, M., & Strużyńska, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063067 · Cited by 11
“In the case of particulate silver, direct dynamic interactions with different proteins are possible which tend to create reversible or irreversible protein coronas [21], thereby temporarily modulating the composition of protein-enriched PSDs.”
BackgroundInfluentialCell‐type‐specific visualisation and biochemical isolation of endogenous synaptic proteins in mice
Zhu, F., Collins, M. O., Harmse, J., Choudhary, J. S., Grant, S. G. N., & Komiyama, N. H. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14597 · Cited by 18
Cell-type specific visualization and biochemical isolation of endogenous synaptic proteins in mice
Zhu, F., Collins, M., Harmse, J., Choudhary, J., Grant, S., & Komiyama, N. (2018) · bioRxiv · doi:10.1101/363614 · Cited by 9
Cullin-RING Ubiquitin Ligases in Neurodevelopment and Neurodevelopmental Disorders
Ashitomi, H., Nakagawa, T., Nakagawa, M., & Hosoi, T. (2025) · Biomedicines · doi:10.3390/biomedicines13040810 · Cited by 10
“…such as glutamate, dopamine, acetylcholine (ACh), and gamma-aminobutyric acid (GABA), which bind to their corresponding receptors in the specialized postsynaptic density (PSD) region of the postsynaptic neurons [131], thereby enabling communication and the transmission of information.”
Hippocampal proteomic changes in high-fat diet-induced obese mice associated with memory decline
Lu, P., Gao, C.-X., Luo, F.-J., Huang, Y.-T., Gao, M., & Long, Y. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109554 · Cited by 7
Comprehensive analysis of slow-fast denatured Morris-Lecar neurons
Ghosh, I., Fatoyinbo, H. O., & Muni, S. S. (2025) · Physical review. E · doi:10.1103/physreve.111.044204 · Cited by 7
Kaizuka, T., Hirouchi, T., Saneyoshi, T., Shirafuji, T., Collins, M. O., Grant, S. G. N., Hayashi, Y., & Takumi, T. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002006 · Cited by 12
Self-citationMelišková, V., Havránek, T., Bačová, Z., & Bakoš, J. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2004106 · Cited by 7
“synaptic scaffolding proteins at glutamatergic and gammaaminobutyric acid–(GABA)ergic–synapses, thereby suggesting their involvement in the etiology of neurodevelopmental disorders [10, 11].”
BackgroundMolecular Physiology of the Neuronal Synapse
Ramírez-Expósito, M. J., Cueto-Ureña, C., & Martínez-Martos, J. M. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48010088 · Cited by 6
“In the early 2000s, major advances occurred with the discovery that the synapse proteome is complex, comprising over a thousand conserved proteins, particularly within excitatory synapses [9].”
InfluentialRemodeling of the postsynaptic proteome in male mice and marmosets during synapse development
Kaizuka, T., Suzuki, T., Kishi, N., Tamada, K., Kilimann, M. W., Ueyama, T., Watanabe, M., Shimogori, T., Okano, H., Dohmae, N., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46529-9 · Cited by 9
“Proteome analysis of the PSD has been performed for various species under both physiological and pathological conditions 18 .”
BackgroundSelf-citationVilela, J. E. R., Martiniano, H., Marques, A. R., Santos, J. X., Asif, M., Rasga, C., Oliveira, G., & Vicente, A. M. (2023) · Biomedicines · doi:10.3390/biomedicines11112971 · Cited by 7
“…that genes encoding synaptic proteins, including synaptic adhesion molecules such as neuroligins, neurexins, cadherins and contactins, synaptic scaffold proteins, ion channels and neurotransmitter receptors are involved in ASD and in other neurodevelopmental and neurological disorders [22].”
BackgroundMinehart, J. A., & Speer, C. M. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.615059 · Cited by 9
Hrynchak, M. V., Rierola, M., Golovyashkina, N., Penazzi, L., Pump, W. C., David, B., Sündermann, F., Brandt, R., & Bakota, L. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00016 · Cited by 7
Hsu, T.-T., Chen, C.-P., Lin, M.-H., Hung, T.-E., Huang, T., Wang, C.-Y., & Hsueh, Y. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03340-2 · Cited by 3
eSylites: Synthetic Probes for Visualization and Topographic Mapping of Single Excitatory Synapses
Huhn, C., Ho, S., Schulte, C., Khayenko, V., Hemmen, K., Peulen, T.-O., Wiessler, A.-L., Bothe, S., Bej, A., Talucci, I., et al. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c00772 · Cited by 6
Development of Peptide-Based Probes for Molecular Imaging of the Postsynaptic Density in the Brain
Fernandes, E. F. A., Palner, M., Raval, N. R., Jeppesen, T. E., Danková, D., Bærentzen, S. L., Werner, C. D., Eilts, J., Maric, H. M., Doose, S., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00615 · Cited by 6
Li, D., Sun, N., Guo, Y., Huang, S., Yin, C., Xiao, Y., & Ma, W. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04136-1 · Cited by 5
“…induce global alterations in PSD composition, and according to literature, the size of the post-synaptic compartment, including the quantity of PSD-95, can autonomously influence the number of AMPARs [31], which may be one of the reasons for changes in psychological and cognitive characteristics.”
PSINDB: the postsynaptic protein–protein interaction database
Kálmán, Z. E., Dudola, D., Mészáros, B., Gáspári, Z., & Dobson, L. (2022) · Database · doi:10.1093/database/baac007 · Cited by 6
“Mutations in postsynaptic proteins are responsible for a wide range of neurological and psychiatric diseases (6), many of them likely to be heritable as suggested by a growing number of evidence, such as in the case of autism spectrum disorder (7, 8).”
Razar, R. B. B. A., Qu, Y., Gunaseelan, S., & Chua, J. J. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.327327 · Cited by 5
“Curiously, loss of FEZ1 in an adult hippocampal neurogenesis model reportedly induces over-proliferation of dendrites without impairing axon development (Kang et al., 2011).”
BackgroundMapping Functional Protein Neighborhoods in the Mouse BrainPreprint
Liebeskind, B. J., Young, R. L., Halling, D. B., Aldrich, R. W., & Marcotte, E. M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.26.920447 · Cited by 5
“loci for autism spectrum disorder, like cell adhesion (Stewart, 2015), postsynaptic density (Kaizuka and Takumi, 2018), the cytoskeleton (Lasser et al.”
BackgroundDisentangling the role of tau pathology in autism spectrum disorders
Villavicencio-Tejo, F., Olesen, M. A., Moya, M. L., & Quintanilla, R. A. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111496 · Cited by 4
Altered odor perception in Dlgap2 mutant mice, a mouse model of autism spectrum disorder
Chen, Y.-F., Tsao, C.-Y., Chen, Y.-T., Chang, H., Li, W., Chiang, J.-Y., Chen, C.-F. F., Chen, C., Gau, S. S., Lee, K., et al. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115365 · Cited by 4
Kim, S. R., Eom, Y., & Lee, S. H. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105570 · Cited by 6
Tyrtyshnaia, A. A., Manzhulo, O. S., & Manzhulo, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210014 · Cited by 5
“1) encodes a protein that is expressed in the postsynaptic density (PSD) and is inherently associated with the regulation of synaptic plasticity and hence memory consolidation processes [51].”
BackgroundKaizuka, T., Suzuki, T., Kishi, N., Kilimann, M. W., Ueyama, T., Watanabe, M., Okano, H., Dohmae, N., & Takumi, T. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.05.490828 · Cited by 4
Self-citationYim, K., Baumgartner, M., Krenzer, M., Larios, M. F. R., Hill-Terán, G., Nottoli, T., Muhle, R., & Noonan, J. P. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100986 · Cited by 12
Time series analysis of coupled slow–fast neuron models: From Hurst exponent to Granger causality
Ghosh, I., Fatoyinbo, H. O., & Muni, S. S. (2025) · Chaos An Interdisciplinary Journal of Nonlinear Science · doi:10.1063/5.0291493 · Cited by 1
“…those consisting of asymmetric junctions alongside a dense protein complex associated with the postsynaptic membranes of the excitatory synapses [Kaizuka and Takumi, 2018], and negative coupling represents those consisting of symmetrical synaptic junctions alongside lacking the dense protein…”
Abdullah, A. H. A., Jufri, N. F., Masre, S. F., Rajab, N. F., Damanhuri, H. A., Roos, N. A. C., & Ibrahim, F. W. (2024) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2024-0041 · Cited by 3
“SYN is a glycoprotein that is present in the membrane of neuron synaptic vesicles [40] and PSD95 is a protein complex that is attached to the postsynaptic membrane [41], so the decreased level of both proteins indicated that synapse signaling is a ff ected.”
Karatoprak, S., Açıkel, S., Akyildiz, A., Çoşkun, F., & Yerlikaya, F. (2022) · International Journal of Developmental Disabilities · doi:10.1080/20473869.2022.2137287 · Cited by 3
“Previous studies have also shown that the changes in cell adhesion molecules, scaffold proteins, receptors and cyto-skeletal proteins, which play a key role in synaptic transmission and plasticity, might be associated with many neurodevelopmental disorders, including ASD (Kaizuka and Takumi 2018).”
How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle
Wang, T., TRABZONLU, K., Jones, E. F., & Syed, Y. A. (2025) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.70009 · Cited by 2
“15 During embryonic development in mice, PSD maturation follows a sequential process: GKAP binds to PSD-95 fi rst, followed by SHANK protein incorporation, re fl ecting dynamic synaptogenesis.”
InfluentialMeringolo, M., Montanari, M., D’Antoni, S., Martella, G., Atiallah, I. E., Ponterio, G., Tassone, A., Reverte, I., Caprioli, D., Strimpakos, G., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70253 · Cited by 3
“Overwhelming evidence correlates PSD-95 disruption to cognitive and learning deficits in ASD (Kaizuka and Takumi 2018).”
Vellucci, L., Simone, G. D., Morley‐Fletcher, S., Buonaguro, E. F., Avagliano, C., Barone, A., Maccari, S., Iasevoli, F., & de Bartolomeis, A. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111032 · Cited by 2
“…Homer family proteins, Shank family proteins, and Postsynaptic density protein 95 - PSD-95) have been linked to neurodevelopmental disorders also emerging after perinatal stress exposure (Berdenis van Berlekom et al. 2020; Buonaguro et al. 2020; Kaizuka and Takumi 2018; Osimo et al. 2019).”
Mazuecos, L., Artigas-Jerónimo, S., Pintado, C., Gómez, O., Rubio, B., Arribas, C., Andrés, A., Villar, M., & Gallardo, N. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122649 · Cited by 2
“These proteins influence the sorting, trafficking, and delivery of synaptic components and organelles, thereby affecting synapse formation and maintenance in the adult hypothalamus [33,34].”
BackgroundSaoud, H., Kereselidze, E., Eybrard, S., & Louilot, A. (2021) · bioRxiv · doi:10.1101/2021.02.16.431488 · Cited by 2
Carbonell, A. U., Freire‐Cobo, C., Deyneko, I. V., Erdjument‐Bromage, H., Clipperton‐Allen, A. E., Rasmusson, R. L., Page, D. T., Neubert, T. A., & Jordan, B. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.02.429412 · Cited by 2
Shah, K., & Zhang, Y. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1831452 · Cited by 1
“Understanding the regulatory roles of CaM is gaining massive significance, as disruptions in the CaM signaling pathway have been associated with neurological disorders like Parkinson’s disease, Alzheimer’s, and Autism spectrum disorders (Kaizuka and Takumi, 2018).”
Metadata
- Authors
- Kaizuka, T., & Takumi, T.
- Affiliations
- RIKEN Center for Brain Science (JP)
- Corresponding author
- Takumi, Toru
- Venue
- The Journal of Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-02-05
- Volume
- 163
- Issue
- 6
- Pages
- 447-455
- ISSN
- 0021-924X (ISSN-L)
- 1756-2651
- OpenAlex
- W2792126067
- Cited by
- 131
- References
- 0
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 24 · 2023: 12 · 2022: 22 · 2021: 19 · 2020: 14 · 2019: 10 · 2018: 3
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- JSPS
- Ministry of Education, Culture, Sports, Science and Technology
- Takeda Science Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- postsynaptic density, postsynaptic density proteins, neurodevelopmental disorders, autism spectrum disorder, schizophrenia, synaptic transmission, synaptic plasticity, excitatory synapses, neuropsychiatric disorders
- MeSH terms
- Animals, Humans, Nerve Tissue Proteins, Proteomics, Neurodevelopmental Disorders
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