The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Postsynaptic density proteins and their involvement in neurodevelopmental disorders
Abstract
Synaptic connections are essential for neural circuits in order to convey brain functions. The postsynaptic density (PSD) is a huge protein complex associated with postsynaptic membranes of excitatory synapses. In mammals, the PSD is composed of more than 1,000 proteins including receptors, scaffold proteins, signalling enzymes and cytoskeletal proteins. PSD proteins are crucial for synaptic transmission and plasticity. Proteomic studies have revealed the composition of PSD proteins in various species, brain regions and specific physiological conditions. Abnormalities with PSD proteins are linked to various neuropsychiatric diseases including neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. Here, we review different kinds of proteomic studies of the PSD and the involvement of PSD proteins in physiological and pathological conditions.
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“In the early 2000s, major advances occurred with the discovery that the synapse proteome is complex, comprising over a thousand conserved proteins, particularly within excitatory synapses [9].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [9]
In the citing paper
“The PSD is characterized by high molecular complexity, comprising over a thousand different proteins in mammals [9].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [9]
In the citing paper
“The integrity and proper function of PSD proteins are paramount, as abnormalities have been strongly linked to various neuropsychiatric diseases, including autism spectrum disorder and schizophrenia [9].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [9]
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“Alterations of these proteins have been associated with many neurological disorders, including ASD [38].”
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“Given that the PSD protein complex contains over 1000 components, such as signaling molecules [59, 60], we postulate that the binding of A β Os to TMEM97 receptor triggers speci fi c signaling pathways in post-synapses, leading to the modulation of gene transcription, thereby driving…”
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“This submembrane protein network consists of cytoskeletal proteins, adhesion and signaling molecules.(42) Thus, Arc protein, being regulated by neuronal activity and bound to the cytoskeleton proteins, link the synaptic activity and structuralfunctional plasticity of neurons.”
Background
Metadata
- Authors
- Kaizuka, T., & Takumi, T.
- Affiliations
- RIKEN Center for Brain Science (JP)
- Corresponding author
- Takumi, Toru
- Venue
- The Journal of Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-02-05
- Volume
- 163
- Issue
- 6
- Pages
- 447-455
- ISSN
- 0021-924X (ISSN-L)
- 1756-2651
- OpenAlex
- W2792126067
- Cited by
- 131
- References
- 0
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 24 · 2023: 12 · 2022: 22 · 2021: 19 · 2020: 14 · 2019: 10 · 2018: 3
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- JSPS
- Ministry of Education, Culture, Sports, Science and Technology
- Takeda Science Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- postsynaptic density, postsynaptic density proteins, neurodevelopmental disorders, autism spectrum disorder, schizophrenia, synaptic transmission, synaptic plasticity, excitatory synapses, neuropsychiatric disorders
- MeSH terms
- Animals, Humans, Nerve Tissue Proteins, Proteomics, Neurodevelopmental Disorders
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