The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Distinguishing Among Evolutionary Models for the Maintenance of Gene Duplicates
Abstract
Determining the evolutionary forces responsible for the maintenance of gene duplicates is key to understanding the processes leading to evolutionary adaptation and novelty. In his highly prescient book, Susumu Ohno recognized that duplicate genes are fixed and maintained within a population with 3 distinct outcomes: neofunctionalization, subfunctionalization, and conservation of function. Subsequent researchers have proposed a multitude of population genetic models that lead to these outcomes, each differing largely in the role played by adaptive natural selection. In this paper, I present a nonmathematical review of these models, their predictions, and the evidence collected in support of each of them. Though the various outcomes of gene duplication are often strictly associated with the presence or absence of adaptive natural selection, I argue that determining the outcome of duplication is orthogonal to determining whether natural selection has acted. Despite an ever-growing field of research into the fate of gene duplicates, there is not yet clear evidence for the preponderance of one outcome over the others, much less evidence for the importance of adaptive or nonadaptive forces in maintaining these duplicates.
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Citations
Cites
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The Neutral Theory of Molecular Evolution
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The Evolutionary Fate and Consequences of Duplicate Genes
Lynch, M., & Conery, J. S. (2000) · Science · doi:10.1126/science.290.5494.1151 · Cited by 4,988
Global variation in copy number in the human genome
Redon, R., Ishikawa, S., Fitch, K. R., Feuk, L., Perry, G. H., Andrews, T. D., Fiegler, H., Shapero, M. H., Carson, A. R., Chen, W., et al. (2006) · Nature · doi:10.1038/nature05329 · Cited by 4,288
Preservation of Duplicate Genes by Complementary, Degenerative Mutations
Force, A., Lynch, M., Pickett, F. B., Amores, A., Yan, Y.-L., & Postlethwait, J. (1999) · Genetics · doi:10.1093/genetics/151.4.1531 · Cited by 3,529
Adaptive protein evolution at the Adh locus in Drosophila
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Evolution by gene duplication: An update
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Cited by
The evolution of gene duplications: classifying and distinguishing between models
Innan, H., & Kondrashov, F. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2689 · Cited by 1,307
Vanneste, K., Baele, G., Maere, S., & Van de Peer, Y. (2014) · Genome Research · doi:10.1101/gr.168997.113 · Cited by 444
The sea lamprey meiotic map improves resolution of ancient vertebrate genome duplications
Smith, J. J., & Keinath, M. C. (2015) · Genome Research · doi:10.1101/gr.184135.114 · Cited by 152
Synteny-Guided Resolution of Gene Trees Clarifies the Functional Impact of Whole-Genome Duplications
Parey, E., Louis, A., Cabau, C., Guiguen, Y., Roest Crollius, H., & Berthelot, C. (2020) · Molecular Biology and Evolution · doi:10.1093/molbev/msaa149 · Cited by 49
Zhao, L., Svetec, N., & Begun, D. J. (2024) · Annual Review of Genetics · doi:10.1146/annurev-genet-111523-102413 · Cited by 38
Metadata
- Authors
- Hahn, M. W.
- Venue
- Journal of Heredity
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-07-13
- Volume
- 100
- Issue
- 5
- Pages
- 605-617
- ISSN
- 0022-1503 (ISSN-L)
- 1465-7333
- OpenAlex
- W2124397449
- Cited by
- 414
- References
- 126
- FWCI
- 15.51
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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