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Cited by 152Chromosomal and Genetic VariationsGenome Rearrangement AlgorithmsGenomics and Phylogenetic Studies

The sea lamprey meiotic map improves resolution of ancient vertebrate genome duplications

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Smith, Jeramiah J., Keinath, Melissa C.·2015·Genome Research
DOI 10.1101/gr.184135.114PMC PMC4509993

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Abstract

It is generally accepted that many genes present in vertebrate genomes owe their origin to two whole-genome duplications that occurred deep in the ancestry of the vertebrate lineage. However, details regarding the timing and outcome of these duplications are not well resolved. We present high-density meiotic and comparative genomic maps for the sea lamprey ( Petromyzon marinus ), a representative of an ancient lineage that diverged from all other vertebrates ∼550 million years ago. Linkage analyses yielded a total of 95 linkage groups, similar to the estimated number of germline chromosomes (1n ∼ 99), spanning a total of 5570.25 cM. Comparative mapping data yield strong support for the hypothesis that a single whole-genome duplication occurred in the basal vertebrate lineage, but do not strongly support a hypothetical second event. Rather, these comparative maps reveal several evolutionarily independent segmental duplications occurring over the last 600+ million years of chordate evolution. This refined history of vertebrate genome duplication should permit more precise investigations of vertebrate evolution.

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  • Comparison of chromosome-scale genomes across vertebrates has clarified the timing and consequences of ancient whole-genome duplications that led to extant vertebrate genomes, supporting Ohno's hypothesis.

    “Comparison of chromosome-scale genomes across vertebrates has clarified the timing and consequences of the ancient whole-genome duplications (WGDs) that led to extant vertebrate genomes (59–65), supporting Ohno's (66) hypothesis.”

    From Topological Approaches in Animal Comparative Genomics (2026) · cites this paper as [59]

    The Abstract reports that comparative mapping clarified vertebrate genome-duplication history, and the Conclusions discuss its evolutionary consequences. But the Abstract finds strong support for one ancestral whole-genome duplication, not strong support for a second; the citing sentence presents ancient WGDs in the plural without that qualification. The paper discusses Ohno's proposal of at least one duplication. (LLM, conf=0.86)

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Authors
Smith, J. J., & Keinath, M. C.
Affiliations
University of Kentucky (US)
ORCID
Venue
Genome Research
Publisher
Cold Spring Harbor Laboratory
Published
2015-06-05
Volume
25
Issue
8
Pages
1081-1090
ISSN
  • 1088-9051 (ISSN-L)
  • 1549-5469
DOI
10.1101/gr.184135.114
PMC
PMC4509993
OpenAlex
W2155062762
Cited by
152
References
1
Citations by year
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Type
posted content
Language
en
Open access
Licence
cc-by-nc
Locations
  • Genome Research (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • UKnowledge (University of Kentucky) (submittedVersion, cc-by-nc)
Funders
  • National Institutes of Health (R01GM104123)
  • University of Kentucky
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords
sea lamprey, whole-genome duplication, linkage groups, segmental duplication, vertebrate evolution, chordate evolution
MeSH terms
Animals, Chromosome Mapping, Chromosomes, Humans, Meiosis, Phylogeny, Vertebrates, Genome, Evolution, Molecular, Gene Duplication, Synteny, Petromyzon

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