Good Clinical Response to Gefitinib in a Non-small Cell Lung Cancer Patient Harboring a Rare Somatic Epidermal Growth Factor Gene Point Mutation; Codon 768 AGC > ATC in Exon 20 (S768I)
Abstract
Recently, two small-molecule kinase inhibitors targeting epidermal growth factor receptor have proven effective in the treatment of non-small cell lung cancer. There are specific activating mutations within the tyrosine kinase domain of epidermal growth factor receptor related to the sensitivity of tyrosine kinase inhibitors. However, it is unknown whether rare mutations in the N-lobe (exons 18-20) and the C-lobe (exon 21) of the epidermal growth factor receptor kinase domain other than L858R in exon 21 and the in-frame deletion in exon 19 may predict the effectiveness of epidermal growth factor receptor-tyrosine kinase inhibitors. We reported a case of non-small cell lung cancer harboring a rare epidermal growth factor somatic mutation, codon 768 AGC > ATC in exon 20 (S768I), who showed a good clinical response to gefitinib. Therefore, we may suggest that this rare mutation (S768I in exon 20) may not be an insensitive epidermal growth factor receptor somatic mutation in vivo.
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Several retrospective studies and case reports of first-generation EGFR-TKIs showed inconsistent responses in patients with NSCLC harboring uncommon EGFR mutations.
“Several retrospective studies and case reports of fi rst-generation EGFR-TKIs showed inconsistent responses in patients with NSCLC harboring uncommon EGFR mutations.”
From Osimertinib for Patients With Non–Small-Cell Lung Cancer Harboring Uncommon EGFR Mutations: A Multicenter, Open-Label, Phase II Trial (KCSG-LU15-09) (2020) · cites this paper as [23]
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- Authors
- Masago, K., Fujita, S., Irisa, K., Kim, Y. H., Ichikawa, M., Mio, T., & Mishima, M.
- Affiliations
- Kyoto University (JP)
- Foundation for Biomedical Research and Innovation (JP)
- Corresponding author
- Masago, K.
- Venue
- Japanese Journal of Clinical Oncology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06-03
- Volume
- 40
- Issue
- 11
- Pages
- 1105-1109
- ISSN
- 0368-2811 (ISSN-L)
- 1465-3621
- OpenAlex
- W2130784618
- Cited by
- 51
- References
- 0
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 7 · 2018: 4 · 2017: 2 · 2016: 8 · 2015: 8 · 2014: 8 · 2013: 3 · 2012: 3
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Japanese Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Keywords
- gefitinib, non-small cell lung cancer, epidermal growth factor receptor, tyrosine kinase inhibitor sensitivity, EGFR tyrosine kinase inhibitors, predictive biomarkers
- MeSH terms
- Gefitinib, Aged, 80 and over, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Exons, Humans, Lung Neoplasms, Male, Prognosis, Quinazolines, Point Mutation, ErbB Receptors
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