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Epigenetic changes of DNA repair genes in cancer
Open accessAbstract
'Every Hour Hurts, The Last One Kills'. That is an old saying about getting old. Every day, thousands of DNA damaging events take place in each cell of our body, but efficient DNA repair systems have evolved to prevent that. However, our DNA repair system and that of most other organisms are not as perfect as that of Deinococcus radiodurans, for example, which is able to repair massive amounts of DNA damage at one time. In many instances, accumulation of DNA damage has been linked to cancer, and genetic deficiencies in specific DNA repair genes are associated with tumor-prone phenotypes. In addition to mutations, which can be either inherited or somatically acquired, epigenetic silencing of DNA repair genes may promote tumorigenesis. This review will summarize current knowledge of the epigenetic inactivation of different DNA repair components in human cancer.
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Cites
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Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
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Concomitant inactivation of p53 and Chk2 in breast cancer
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Cited by
Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors
Saghafinia, S., Mina, M., Riggi, N., Hanahan, D., & Ciriello, G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.082 · Cited by 357
Drug resistance in cancer: mechanisms and tackling strategies
Haider, T., Pandey, V., Banjare, N., Gupta, P. N., & Soni, V. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00138-7 · Cited by 282
Cellular and epigenetic drivers of stem cell ageing
Ermolaeva, M., Neri, F., Ori, A., & Rudolph, K. L. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0020-3 · Cited by 272
Neven, K. Y., Saenen, N. D., Tarantini, L., Janssen, B. G., Lefebvre, W., Vanpoucke, C., Bollati, V., & Nawrot, T. S. (2018) · The Lancet Planetary Health · doi:10.1016/s2542-5196(18)30049-4 · Cited by 103
Panagopoulos, D., Karabarbounis, A., Yakymenko, I., & Chrousos, G. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5272 · Cited by 73
Metadata
- Authors
- Lahtz, C., & Pfeifer, G. P.
- Venue
- Journal of Molecular Cell Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01-30
- Volume
- 3
- Issue
- 1
- Pages
- 51-58
- ISSN
- 1674-2788 (ISSN-L)
- OpenAlex
- W2139097459
- Cited by
- 217
- References
- 6
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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