Cellular and epigenetic drivers of stem cell ageing

Translating the Histone Code

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Shedding light on the cell biology of extracellular vesicles

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A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

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DNA methylation age of human tissues and cell types

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Notch Signaling: Cell Fate Control and Signal Integration in Development

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Wnt/β-Catenin Signaling in Development and Disease

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The Wnt Signaling Pathway in Development and Disease

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Age-related clonal hematopoiesis associated with adverse outcomes

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Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

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Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

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Aging, Cellular Senescence, and Cancer

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

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Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

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Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease

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The bone marrow niche for haematopoietic stem cells

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Rejuvenation of aged progenitor cells by exposure to a young systemic environment

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Satellite Cells and the Muscle Stem Cell Niche

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An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

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Defining the Epithelial Stem Cell Niche in Skin

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Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

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The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.Preprint

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Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

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High burden and pervasive positive selection of somatic mutations in normal human skin

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The ageing systemic milieu negatively regulates neurogenesis and cognitive function

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Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

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Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

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Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

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NAD+ and sirtuins in aging and disease

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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

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Programmed cell senescence during mammalian embryonic development

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Designer matrices for intestinal stem cell and organoid culture

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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

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Autophagy maintains stemness by preventing senescence

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Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

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Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

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MLL translocations, histone modifications and leukaemia stem-cell development

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NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

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Promoting Health and Longevity through Diet: From Model Organisms to Humans

Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245 · see citing works

Senescence is a developmental mechanism that contributes to embryonic growth and patterning

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Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

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Dnmt3a is essential for hematopoietic stem cell differentiation

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Notch-Mediated Restoration of Regenerative Potential to Aged Muscle

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Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

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Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

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Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

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Cellular Senescence in Aging Primates

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The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

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Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

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Feedback between p21 and reactive oxygen production is necessary for cell senescence

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Geriatric muscle stem cells switch reversible quiescence into senescence

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In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.

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CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

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daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

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Tissue-specific mutation accumulation in human adult stem cells during life

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Autophagy maintains the metabolism and function of young and old stem cells

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Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

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The aged niche disrupts muscle stem cell quiescence

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A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan

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Aging of blood can be tracked by DNA methylation changes at just three CpG sites

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Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

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Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle

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Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

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Hematopoietic stem cell niche maintenance during homeostasis and regeneration

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Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

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Intestinal label-retaining cells are secretory precursors expressing Lgr5

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mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

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Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

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The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

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Intragenic DNA methylation prevents spurious transcription initiation

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The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

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Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

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Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

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Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

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Haematopoietic stem cells require a highly regulated protein synthesis rate

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Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells

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Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

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Aging effects on DNA methylation modules in human brain and blood tissue

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Mitochondrial DNA mutations in disease and aging

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Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

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Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

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The ageing haematopoietic stem cell compartment

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Increased cell-to-cell variation in gene expression in ageing mouse heart

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