The DOI matches its Crossref record; 23 of the 25 references it cites were found in a registry or an index.
Probiotic Immunomodulation in Health and Disease
Open accessAbstract
Probiotics, microorganisms that have a favorable influence on physiologic and pathological processes of the host by their effect on the intestinal flora, may play a role in improving human health. One of the putative effects is the modulation of immune function. Thus, the mucosal immune system and methods to assess its function are reviewed briefly. Probiotic modulation of humoral, cellular and nonspecific immunity is reviewed, with emphasis placed on immune response in disease models. There are very few reports of human intervention studies with probiotics. However, some of the possible future directions for research with respect to probiotics, immunity, and human health are discussed. Although the application of probiotics has demonstrated trends with respect to altered aspects of immune response, the underlying mechanisms by which that occurs are unclear.
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“Some LAB strains can modulate innate and acquired immune responses by binding to specific receptors on immune cells and other tissues such as intestinal epithelial tissue, and by stimulating the production of cytokines, T cells, the activation of dendritic cells and macrophages, and the production of specific antibodies [229,230,231].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [229]
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Cites
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Cited by
Sorted by citations
Probiotic bacteria enhance murine and human intestinal epithelial barrier function
Madsen, K., Cornish, A. S., Soper, P., McKaigney, C. J., Jijon, H. B., Yachimec, C., Doyle, J. S. G., Jewell, L. D., & Simone, C. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.27224 · Cited by 1,096
Christensen, H. R., Frøkiær, H., & Pestka, J. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.171 · Cited by 905
Hatakka, K., Savilahti, E., Pönkä, A., Meurman, J. H., Poussa, T., Näse, L., Saxelin, M., & Korpela, R. (2001) · BMJ · doi:10.1136/bmj.322.7298.1327 · Cited by 645
Immune System Stimulation by Probiotic Microorganisms
Ashraf, R., & Shah, N. P. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.619671 · Cited by 558
Weizman, Z., Asli, G., & Alsheikh, A. (2005) · Pediatrics · doi:10.1542/peds.2004-1815 · Cited by 548
Metadata
- Authors
- Erickson, K. L., & Hubbard, N. E.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Erickson, Kent L.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 130
- Issue
- 2
- Pages
- 403S-409S
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W1946934775
- Cited by
- 372
- References
- 25
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 14 · 2021: 10 · 2020: 19 · 2019: 8 · 2018: 15 · 2017: 7 · 2016: 6 · 2015: 21 · 2014: 16 · 2013: 15 · 2012: 21
- FWCI
- 26.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- probiotics, immunomodulation, mucosal immunity, gut microbiota, humoral immunity, cell-mediated immunity, non-specific immunity, disease models, human health
- MeSH terms
- Animals, Disease Models, Animal, Humans, Immune System, Intestines, Immunity, Mucosal, Probiotics
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