Cited by 372Probiotics and Fermented FoodsGut microbiota and healthMicrobial Metabolites in Food Biotechnology

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Probiotic Immunomodulation in Health and Disease

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Erickson, Kent L., Hubbard, Neil E.·2000·The Journal of Nutrition

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Abstract

Probiotics, microorganisms that have a favorable influence on physiologic and pathological processes of the host by their effect on the intestinal flora, may play a role in improving human health. One of the putative effects is the modulation of immune function. Thus, the mucosal immune system and methods to assess its function are reviewed briefly. Probiotic modulation of humoral, cellular and nonspecific immunity is reviewed, with emphasis placed on immune response in disease models. There are very few reports of human intervention studies with probiotics. However, some of the possible future directions for research with respect to probiotics, immunity, and human health are discussed. Although the application of probiotics has demonstrated trends with respect to altered aspects of immune response, the underlying mechanisms by which that occurs are unclear.

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Authors: Erickson, K. L., & Hubbard, N. E.
Affiliations: University of California, Davis (US)
Corresponding author: Erickson, Kent L.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2000-02
Volume: 130
Issue: 2
Pages: 403S-409S
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/130.2.403s
OpenAlex: W1946934775
Cited by: 372
References: 25
Citations by year: 2026: 2 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 14 · 2021: 10 · 2020: 19 · 2019: 8 · 2018: 15 · 2017: 7 · 2016: 6 · 2015: 21 · 2014: 16 · 2013: 15 · 2012: 21
FWCI: 26.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 8396 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: probiotics, immunomodulation, mucosal immunity, gut microbiota, humoral immunity, cell-mediated immunity, non-specific immunity, disease models, human health
MeSH terms: Animals, Disease Models, Animal, Humans, Immune System, Intestines, Immunity, Mucosal, Probiotics

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