Lecithin:Retinol Acyltransferase Expression Is Regulated by Dietary Vitamin A and Exogenous Retinoic Acid in the Lung of Adult Rats
Open accessAbstract
Lecithin:retinol acyltransferase (LRAT), a retinol esterifying enzyme, plays a major role in the metabolism and storage of vitamin A in several animal tissues. Groups of vitamin A (VA)-adequate (control) and VA-deficient rats were treated with vehicle or 5 mg of all-trans-retinoic acid (RA); an additional group of VA-deficient rats were fed 100 microg of RA. In control rats, lung LRAT mRNA and LRAT specific activity were approximately 50% of the levels expressed in the liver. In the lung of VA-deficient rats, LRAT mRNA and specific activity levels were <10% of those in the control group. Treatment of VA-deficient rats with 100 microg RA increased lung LRAT mRNA (P < 0.005) and specific activity (P < 0.0001), and treatment with 5 mg of RA increased LRAT mRNA level and specific activity more than approximately 15- and 6-fold above those in control lung, respectively (both P < or = 0.001). The lung tissue of VA-adequate rats contained retinyl ester (approximately 3 nmol/g tissue), whereas none was detected in the lung tissue of VA-deficient rats. These results show that LRAT expression and vitamin A storage are regulated by vitamin A status and by treatment with all-trans-RA in the adult lung. These results suggest that the regulated storage of vitamin A may be important for maintaining the integrity and physiologic functions of the lung.
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Elevated LRAT activity was attributed to induction of LRAT expression leading to a higher concentration of the enzyme rather than through activation of the enzyme by an allosteric mechanism or a posttranslational modification.
“The elevated LRAT activity was attributed to induction of LRAT expression leading to a higher concentration of the enzyme rather than through activation of the enzyme by an allosteric mechanism or a posttranslational modification [120].”
From Molecular Basis for Vitamin A Uptake and Storage in Vertebrates (2016) · cites this paper as [120]
The same phenomenon of LRAT activity induction applied to other tissues including lungs but not small intestines and is conserved in mice.
“The same phenomenon applied to other tissues including lungs but not small intestines and it is conserved in mice [119,120].”
From Molecular Basis for Vitamin A Uptake and Storage in Vertebrates (2016) · cites this paper as [120]
Cites
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Self-citationVitamin A status regulates hepatic lecithin: retinol acyltransferase activity in rats.
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Self-citationRegulation of Hepatic Lecithin: Retinol Acyltransferase Activity by Retinoic Acid
Matsuura, T., & Ross, A. C. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1137 · Cited by 74 · see citing works
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Self-citationDelivery of retinoid-based therapies to target tissues
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Molecular Basis for Vitamin A Uptake and Storage in Vertebrates
Chelstowska, S., Widjaja-Adhi, M., Silvaroli, J., & Golczak, M. (2016) · Nutrients · doi:10.3390/nu8110676 · Cited by 69 · see citing works
“The same phenomenon applied to other tissues including lungs but not small intestines and it is conserved in mice [119,120].”
BackgroundBok, D., Ruiz, A., Yaron, O., Jahng, W. J., Ray, A., Xue, L., & Rando, R. R. (2003) · Biochemistry · doi:10.1021/bi0342416 · Cited by 47 · see citing works
- Authors
- Zolfaghari, R., & Ross, A. C.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Ross, A. Catharine
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 132
- Issue
- 6
- Pages
- 1160-1164
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W1914530609
- Cited by
- 45
- References
- 4
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA 90274)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 48869)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- LRAT, vitamin A status, retinoic acid, lung, vitamin A deficiency, retinol esterification, vitamin A storage, gene expression regulation, retinyl esters, lung function
- MeSH terms
- Acyltransferases, Animals, Enzyme Induction, Liver, Lung, Rats, Inbred Lew, RNA, Messenger, Tretinoin, Vitamin A, Vitamin A Deficiency, Gene Expression Regulation, Enzymologic, Rats
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