Regulation of Hepatic Lecithin: Retinol Acyltransferase Activity by Retinoic Acid
Abstract
The activity of the hepatic enzyme lecithin: retinol acyltransferase (LRAT), thought to catalyze the esterification of retinol for storage, was previously shown to vary directly with the vitamin A (retinol) status of the rat [Randolph, R. K., and Ross, A. C. (1991) J. Biol. Chem. 266, 16453-16457]. The present studies were designed to determine whether liver LRAT activity is regulated in vivo by retinoic acid, a principal active metabolite of retinol. LRAT activity was negligible in the livers of vitamin A-deficient rats. Following treatment with a single 2-micrograms dose of retinoic acid, LRAT activity increased significantly while, following treatment with a single 20-micrograms dose, liver LRAT activity equalled that of vitamin A-sufficient adult rats. Retinoic acid was more effective than an equimolar quantity of retinol in restoring LRAT activity in the vitamin A-deficient rat liver. The increase in hepatic LRAT activity after administration of retinoic acid occurred rapidly, reaching a maximum within 12-16 h but declining again after 48-72 h. Studies were conducted in vivo to gain insight into the level of regulation of LRAT by retinoic acid. The increase in LRAT activity by retinoic acid in the vitamin A-deficient rat was blocked completely by both actinomycin D and cycloheximide. The ability of liver to esterify retinol in vivo was correlated with the in vitro activity of LRAT after retinoic acid induction. We conclude that retinoic acid, an important end product of retinol metabolism, regulates a key aspect of hepatic retinol metabolism through its regulatory activity on liver LRAT.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LRAT activity could be induced by retinoic acid or supplemental vitamin A.
“Interestingly, LRAT activity could be induced by retinoic acid or supplemental vitamin A [117,118].”
From Molecular Basis for Vitamin A Uptake and Storage in Vertebrates (2016) · cites this paper as [118]
LRAT activity was much lower in the liver of vitamin A deficient rats compared to control animals.
“The initial studies by Dr. Ross and colleagues indicated that LRAT activity was much lower in the liver of vitamin A deficient rats as compared to the control animals.”
From Molecular Basis for Vitamin A Uptake and Storage in Vertebrates (2016) · cites this paper as [118]
Cites
Still being checked.
Cited by
Sorted by citations
Interactions of retinoid binding proteins and enzymes in retinoid metabolism
Napoli, J. L. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00117-1 · Cited by 409 · see citing works
Retinol and retinyl esters: biochemistry and physiology
O'Byrne, S. M., & Blaner, W. S. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r037648 · Cited by 378 · see citing works
Fletcher, A. L., Malhotra, D., Acton, S. E., Lukacs‐Kornek, V., Bellemare‐Pelletier, A., Curry, M. S., Armant, M. A., & Turley, S. J. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00035 · Cited by 244 · see citing works
Scientific Opinion on Dietary Reference Values for vitamin A
EFSA Panel on Dietetic Products, N. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4028 · Cited by 240 · see citing works
Retinoids and mammalian development.
Morriss-Kay, G., & Ward, S. (1999) · International Review of Cytology · doi:10.1016/s0074-7696(08)61566-1 · Cited by 120 · see citing works
Retinoic Acid: Its Biosynthesis and Metabolism
Napoli, J. L. (1999) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60722-9 · Cited by 187 · see citing works
Liu, L., & Gudas, L. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509643200 · Cited by 181 · see citing works
Transport and Metabolism of Vitamin A
Blomhoff, R. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1994.tb01382.x · Cited by 175 · see citing works
Ross, A. C. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.1.291s · Cited by 161 · see citing works
Self-citationLiver Retinol Transporter and Receptor for Serum Retinol-binding Protein (RBP4)
Alapatt, P., Guo, F., Komanetsky, S. M., Wang, S., Cai, J., Sargsyan, A., Rodríguez Díaz, E., Bacon, B. T., Aryal, P., & Graham, T. E. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.369132 · Cited by 150 · see citing works
Kurlandsky, S. B., Duell, E. A., Kang, S., Voorhees, J. J., & Fisher, G. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.26.15346 · Cited by 134 · see citing works
Andreola, F., Fernández‐Salguero, P. M., Chiantore, M. V., Petkovich, M. P., Gonzalez, F. J., & Luca, L. M. D. (1997) · PubMed · Cited by 131 · see citing works
Regulation of Hepatic Retinol Metabolism: Perspectives from Studies on Vitamin A Status
Ross, A. C., & Zolfaghari, R. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.269s · Cited by 126 · see citing works
Self-citationHow degrading: Cyp26s in hindbrain development
White, R. J., & Schilling, T. F. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21695 · Cited by 105 · see citing works
Amimo, J. O., Michael, H., Chepngeno, J., Raev, S. A., Saif, L. J., & Vlasova, A. N. (2022) · Nutrients · doi:10.3390/nu14235038 · Cited by 105 · see citing works
Zolfaghari, R., & Ross, A. C. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32364-6 · Cited by 96 · see citing works
Self-citationWang, Y., Zolfaghari, R., & Ross, A. C. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00043-7 · Cited by 94 · see citing works
Self-citationBiosynthesis, Absorption, Metabolism and Transport of Retinoids
Vogel, S., Gamble, M. V., & Blaner, W. S. (1999) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-58483-1_2 · Cited by 90 · see citing works
Chung, J. (2001) · Carcinogenesis · doi:10.1093/carcin/22.8.1213 · Cited by 89 · see citing works
Review: absorption and metabolism of beta-carotene.
Wang, X. (1994) · Journal of the American College of Nutrition · doi:10.1080/07315724.1994.10718416 · Cited by 88 · see citing works
Overview of Retinoid Metabolism
Ross, A. C. (1993) · Journal of Nutrition · doi:10.1093/jn/123.suppl_2.346 · Cited by 75 · see citing works
Self-citationMolecular Basis for Vitamin A Uptake and Storage in Vertebrates
Chelstowska, S., Widjaja-Adhi, M., Silvaroli, J., & Golczak, M. (2016) · Nutrients · doi:10.3390/nu8110676 · Cited by 69 · see citing works
“Interestingly, LRAT activity could be induced by retinoic acid or supplemental vitamin A [117,118].”
BackgroundNilsson, C. B., Hoegberg, P., Trossvik, C., Azaı̈s-Braesco, V., Blaner, W. S., Fex, G. A., Harrison, E. H., Nau, H., Schmidt, C. K., van Bennekum, A. M., et al. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2000.9059 · Cited by 67 · see citing works
Endogenous retinoids in the hair follicle and sebaceous gland
Everts, H. B. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.08.017 · Cited by 66 · see citing works
In vivo isomerization of retinoic acids. Rapid isomer exchange and gene expression.
Kojima, R., Fujimori, T., KIYOTA, N., Toriya, Y., Fukuda, T., Ohashi, T., Sato, T., Yoshizawa, Y., Takeyama, K., & Mano, H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31691-0 · Cited by 66 · see citing works
Mechanisms of Feedback Regulation of Vitamin A Metabolism
O'Connor, C., Varshosaz, P., & Moise, A. (2022) · Nutrients · doi:10.3390/nu14061312 · Cited by 53 · see citing works
Retinoids and nephron mass control
Gilbert, T., & Merlet-Bénichou, C. (2000) · Pediatric Nephrology · doi:10.1007/s004670000385 · Cited by 53 · see citing works
Tomokazu, M., Gad, M. Z., Harrison, E., & Catharine, R. A. (1997) · Journal of Nutrition · doi:10.1093/jn/127.2.218 · Cited by 52 · see citing works
Ross, A. C., & Ternus, M. E. (1993) · Journal of the American Dietetic Association · doi:10.1016/0002-8223(93)91956-q · Cited by 50 · see citing works
Self-citationObrochta, K. M., Krois, C. R., Campos, B., & Napoli, J. L. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.609313 · Cited by 48 · see citing works
Zolfaghari, R., & Ross, A. C. (2002) · The Journal of Nutrition · doi:10.1093/jn/132.6.1160 · Cited by 45 · see citing works
Self-citationLevin, M. S., & Davis, A. E. (1997) · Journal of Nutrition · doi:10.1093/jn/127.1.13 · Cited by 43 · see citing works
Nilsson, C. B., Hanberg, A., Trossvik, C., & Håkansson, H. (1996) · Environmental Toxicology and Pharmacology · doi:10.1016/1382-6689(96)00023-3 · Cited by 42 · see citing works
Wolf, G. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2001.tb06968.x · Cited by 39 · see citing works
Regulation of Hepatic Vitamin A Storage in a Rat Model of Controlled Vitamin A Status during Aging
Yamamoto, Y., Zolfaghari, R., Rosales, F. J., Dietz, J. M., Shimada, T., Li, N., Ross, A. C., & Dawson, H. D. (2000) · Journal of Nutrition · doi:10.1093/jn/130.5.1280 · Cited by 36 · see citing works
Self-citationNagatsuma, K., Hayashi, Y., Hano, H., Sagara, H., Murakami, K., Saito, M. M., Masaki, T., Lu, T., Tanaka, M., Enzan, H., et al. (2008) · Liver International · doi:10.1111/j.1478-3231.2008.01773.x · Cited by 35 · see citing works
Self-citationShimada, T., Ross, A. C., Muccio, D. D., Brouillette, W. J., & Shealy, Y. F. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0209 · Cited by 32 · see citing works
Self-citationRoss, A., & Harrison, E. H. (2013) · CRC Press eBooks · doi:10.1201/b15413-2 · Cited by 30 · see citing works
Self-citationZolfaghari, R., & Ross, A. C. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39945-4 · Cited by 31 · see citing works
Self-citationGrolier, P., Agoudavi, S., & Azaı̈s-Braesco, V. (1995) · Nutrition Research · doi:10.1016/0271-5317(95)02023-o · Cited by 27 · see citing works
Fortuna, V., Trugo, L. C., & Borojević, R. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00179-6 · Cited by 27 · see citing works
Ndayibagira, A., & Spear, P. A. (1999) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/s0742-8413(98)10129-9 · Cited by 25 · see citing works
The renal retinoid system: time-dependent activation in experimental glomerulonephritis
Liebler, S., Uberschär, B., Kübert, H., Brems, S., Schnitger, A., Tsukada, M., Zouboulis, C. C., Ritz, E., & Wagner, J. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00173.2003 · Cited by 23 · see citing works
Wu, L., Chaudhary, S., Atigadda, V., Belyaeva, O., Harville, S., Elmets, C., Muccio, D., Athar, M., & Kedishvili, N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153556 · Cited by 21 · see citing works
All-trans-retinoic acid distribution and metabolism in vitamin A-marginal rats
Cifelli, C. J., & Ross, A. C. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00011.2006 · Cited by 23 · see citing works
Self-citationZolfaghari, R., & Ross, A. C. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.08.001 · Cited by 21 · see citing works
Self-citationRandolph, R. K., & Simon, M. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12329900 · Cited by 21 · see citing works
Boily, M. H., Ndayibagira, A., & Spear, P. A. (2003) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(02)00146-1 · Cited by 20 · see citing works
Hoegberg, P., Schmidt, C. K., Nau, H., Ross, A. C., Zolfaghari, R., Fletcher, N., Trossvik, C., Nilsson, C. B., & Håkansson, H. (2003) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00157-6 · Cited by 20 · see citing works
Self-citationArukwe, A., & Nordbø, B. (2008) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2008.02.002 · Cited by 17 · see citing works
N-(4-Hydroxyphenyl)-Retinamide Increases Lecithin:Retinol Acyltransferase Activity in Rat Liver
Matsuura, T., Zhao, Z., & Ross, A. C. (1996) · Journal of Nutrition · doi:10.1093/jn/126.10.2474 · Cited by 17 · see citing works
Self-citationVitamin E supplementation does not prevent ethanol-reduced hepatic retinoic acid levels in rats
Chung, J., Veeramachaneni, S., Liu, C., Mernitz, H., Russell, R. M., & Wang, X. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.09.008 · Cited by 16 · see citing works
Enzymology and biogenesis of retinoic acid
Napoli, J. L. (2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8454-9_2 · Cited by 16 · see citing works
Retinoids in Cutaneous Squamous Cell Carcinoma
Everts, H. B., & Akuailou, E.-N. (2021) · Nutrients · doi:10.3390/nu13010153 · Cited by 15 · see citing works
Zolfaghari, R., Wang, Y., Chen, Q., SANCHER, A., & Ross, A. C. (2002) · Biochemical Journal · doi:10.1042/bj20020918 · Cited by 13 · see citing works
Self-citationRetinol Esterification Activity Contributes to Retinol Transport in Stellate Cells.
Matsuura, T., HASUMURA, S., & Nagamori, K. (1999) · Cell Structure and Function · doi:10.1247/csf.24.111 · Cited by 13 · see citing works
Self-citationGressel, K., Duncan, F. J., Oberyszyn, T. M., Perle, K. M. D. L., & Everts, H. B. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12441 · Cited by 12 · see citing works
Nagatsuma, K., Hano, H., Murakami, K., Shindo, D., Matsumoto, Y., Mitobe, J., Tanaka, K., Saito, M. M., Maehashi, H., Owada, M., et al. (2013) · Liver International · doi:10.1111/liv.12255 · Cited by 12 · see citing works
Self-citationPan, Z., Dan, Z., Fu, Y., Tang, W.-X., & Lin, J. (2006) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-006-0505-8 · Cited by 11 · see citing works
Haga, Y., Takeuchi, T., & Seikai, T. (2004) · Fisheries Science · doi:10.1111/j.1444-2906.2004.00823.x · Cited by 10 · see citing works
O’Byrne, S. M., & Blaner, W. S. (2005) · AOCS Publishing eBooks · doi:10.1201/9781439822371.ch1 · Cited by 9 · see citing works
Shull, J. D., Pennington, K. L., Gurr, J. A., & Ross, A. C. (1995) · Endocrinology · doi:10.1210/en.136.5.2120 · Cited by 8 · see citing works
Self-citationVitamin A: Retinoids and Carotenoids
Ball, G. F. M. (2004) · VITAMINS · doi:10.1002/9780470774571.ch7 · Cited by 7 · see citing works
Ross, A. C., Foulke, D. T., Matsuura, T., Tresini, M., Breen, J. J., & Gurr, J. A. (1997) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(97)00056-9 · Cited by 6 · see citing works
Self-citationBIOMARQUEURS IMMUNOLOGIQUES APPLIQUÉS À L’ÉCOTOXICOLOGIE
FOURNIER, M., Lalancette, A., MÉNARD, L., Christin-Piché, M.-S., Guise, S. D., & Brousseau, P. (2004) · Presses de l'Université du Québec eBooks · doi:10.2307/j.ctv18ph2xj.15 · Cited by 5 · see citing works
McCaffery, P. J. A., Andreola, F., Giandomenico, V., & Luca, L. M. D. (2001) · CRC Press eBooks · doi:10.1201/9781420039108-13 · Cited by 5 · see citing works
Retinoic acid metabolism proteins are altered in trichoblastomas induced by mouse papillomavirus 1
Everts, H. B., Suo, L., Ghim, S., Jenson, A. B., & Sundberg, J. P. (2015) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2015.09.012 · Cited by 4 · see citing works
O’Byrne, S. M. (n.d.) · ProQuest Demo Repository
Energy Metabolism Regulates Retinoic Acid Synthesis and Homeostasis in Physiological Contexts
Obrochta, K. M. (2014) · eScholarship (California Digital Library)
Mezaki, Y., Nagatsuma, K., Yokoyama, H., Park, J. H., Nakamura, M., Masaki, T., Blomhoff, R., Senoo, H., & Matsuura, T. (2017) · Polar Biology · doi:10.1007/s00300-017-2241-x
Self-citationCyr, D. G., Pillet, S., & NICOLAS, J.-M. (2004) · Presses de l'Université du Québec eBooks · doi:10.2307/j.ctv18ph2xj.13
Phosphatidylcholine-retinol O-acyltransferase
(2006) · Springer eBooks · doi:10.1007/3-540-37717-4_76
Ross, A. C., & Harrison, E. H. (2007) · CRC Press eBooks · doi:10.1201/9781420005806.ch1
Self-citationLuca, L. M. D., Andreola, F., Giandomenico, V., & McCaffery, P. J. A. (2001) · Modern nutrition · doi:10.1201/9781420039108.ch13
- Authors
- Matsuura, T., & Ross, A. C.
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 1993-03
- Volume
- 301
- Issue
- 2
- Pages
- 221-227
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2011930381
- Cited by
- 74
- References
- 0
- Citations by year
- 2022: 2 · 2021: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL22633, P01HL022633)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-14684)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- LRAT, retinoic acid, retinol esterification, vitamin A deficiency, hepatic enzyme regulation, vitamin A metabolism, actinomycin D, cycloheximide
- MeSH terms
- Acyltransferases, Animals, Cycloheximide, Dactinomycin, Dose-Response Relationship, Drug, Enzyme Induction, Esterification, Female, Liver, Male, Microsomes, Liver, Phosphatidylcholines, Rats, Inbred Lew, Transcription, Genetic, Protein Biosynthesis, Tretinoin, Vitamin A, Vitamin A Deficiency, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
