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Neonatal Iron Deficiency Results in Irreversible Changes in Dopamine Function in Rats
Open accessAbstract
Iron deficiency in human infants and in young animal models produces changes in neural functioning that may be related to monoamine metabolism. This study employed both behavioral and biochemical approaches in a design using cross-fostering to examine alterations in dopamine (DA) function when iron deficiency occurs during the neonatal period. We measured brain Fe, dopamine transporters (DAT) and dopamine receptor density in rats made iron deficient, or not, from postnatal day (PND) 4 to PND 14 or 21. Some pups were then weaned to an iron-deficient diet and others to the control diet to examine the reversibility of these effects. Behaviors related to dopamine function were measured. Dopamine D(2) receptor (D(2)R), D(1)R and iron concentrations were approximately 70, 80 and 30% of control values, respectively, in the nucleus accumbens and striatum in iron-deficient rats at PND 14. The DAT density was also reduced to 50% of control density in the nucleus accumbens but was unchanged in the striatum. By PND 21, there was also a significant 50% lowering of DAT, D(1)R and D(2)R densities in the prefrontal cortex (PFC). Iron repletion at PND 21-49 normalized D(1)R, D(2)R, and DAT levels in the nucleus accumbens, PFC and ventral midbrain but not in the striatum. In summary, neonatal iron deficiency is associated with changes in DA biology that vary with duration of iron deficiency, and are not completely normalized despite replenishment of iron status. Changes in DA-related behaviors that were persistent after postweaning iron repletion suggest the existence of a critical neonatal developmental period that is expressed by alterations in DA functioning.
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“Deviations from normal iron levels have been indicated in the pathogenesis of aging, neurodegenerative disease, cancer, and infection (18, 23, 156, 180, 299, 334).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [18]
In the citing paper
“Iron deficiency may have deleterious effects on neurotransmission, myelination, and dopamine receptor and transporter functions (18).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [18]
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Metadata
- Authors
- Beard, J., Erikson, K. M., & Jones, B. C.
- Affiliations
- Wake Forest University (US)
- Wake Forest University Health Sciences (US)
- Pennsylvania State University (US)
- Corresponding author
- Beard, John
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 133
- Issue
- 4
- Pages
- 1174-1179
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W1933823002
- Cited by
- 172
- References
- 32
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 9 · 2023: 4 · 2022: 1 · 2021: 7 · 2020: 3 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 6 · 2013: 13 · 2012: 7
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- neonatal iron deficiency, dopaminergic activity, dopamine transporter, dopamine D2 receptor, dopamine D1 receptor, iron repletion, nucleus accumbens, striatum, prefrontal cortex, ventral midbrain, cross-fostering, iron-deficient diet, monoamine metabolism, critical developmental periods
- MeSH terms
- Iron Deficiencies, Animals, Animals, Newborn, Behavior, Animal, Dopamine, Female, Ligands, Male, Membrane Glycoproteins, Nerve Tissue Proteins, Protein Binding, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Rats
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