Cited by 172Iron Metabolism and DisordersTrace Elements in HealthNeurotransmitter Receptor Influence on Behavior

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Neonatal Iron Deficiency Results in Irreversible Changes in Dopamine Function in Rats

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Beard, John, Erikson, Keith M., Jones, Byron C.·2003·The Journal of Nutrition

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Abstract

Iron deficiency in human infants and in young animal models produces changes in neural functioning that may be related to monoamine metabolism. This study employed both behavioral and biochemical approaches in a design using cross-fostering to examine alterations in dopamine (DA) function when iron deficiency occurs during the neonatal period. We measured brain Fe, dopamine transporters (DAT) and dopamine receptor density in rats made iron deficient, or not, from postnatal day (PND) 4 to PND 14 or 21. Some pups were then weaned to an iron-deficient diet and others to the control diet to examine the reversibility of these effects. Behaviors related to dopamine function were measured. Dopamine D(2) receptor (D(2)R), D(1)R and iron concentrations were approximately 70, 80 and 30% of control values, respectively, in the nucleus accumbens and striatum in iron-deficient rats at PND 14. The DAT density was also reduced to 50% of control density in the nucleus accumbens but was unchanged in the striatum. By PND 21, there was also a significant 50% lowering of DAT, D(1)R and D(2)R densities in the prefrontal cortex (PFC). Iron repletion at PND 21-49 normalized D(1)R, D(2)R, and DAT levels in the nucleus accumbens, PFC and ventral midbrain but not in the striatum. In summary, neonatal iron deficiency is associated with changes in DA biology that vary with duration of iron deficiency, and are not completely normalized despite replenishment of iron status. Changes in DA-related behaviors that were persistent after postweaning iron repletion suggest the existence of a critical neonatal developmental period that is expressed by alterations in DA functioning.

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Authors: Beard, J., Erikson, K. M., & Jones, B. C.
Affiliations: Wake Forest University (US)
Wake Forest University Health Sciences (US)
Pennsylvania State University (US)
Corresponding author: Beard, John
ORCID: Erikson, Keith M.
Jones, Byron C.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2003-04
Volume: 133
Issue: 4
Pages: 1174-1179
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/133.4.1174
OpenAlex: W1933823002
Cited by: 172
References: 32
Citations by year: 2026: 4 · 2025: 3 · 2024: 9 · 2023: 4 · 2022: 1 · 2021: 7 · 2020: 3 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 6 · 2013: 13 · 2012: 7
FWCI: 4.13
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7251 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: neonatal iron deficiency, dopaminergic activity, dopamine transporter, dopamine D2 receptor, dopamine D1 receptor, iron repletion, nucleus accumbens, striatum, prefrontal cortex, ventral midbrain, cross-fostering, iron-deficient diet, monoamine metabolism, critical developmental periods
MeSH terms: Iron Deficiencies, Animals, Animals, Newborn, Behavior, Animal, Dopamine, Female, Ligands, Male, Membrane Glycoproteins, Nerve Tissue Proteins, Protein Binding, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Rats

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Neonatal Iron Deficiency Results in Irreversible Changes in Dopamine Function in Rats

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