Cited by 240Phytochemicals and Antioxidant ActivitiesFlavonoids in Medical ResearchBioactive Compounds and Antitumor Agents

The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.

Low Concentrations of Flavonoids Are Protective in Rat H4IIE Cells Whereas High Concentrations Cause DNA Damage and Apoptosis,

Open access

Wätjen, Wim, Michels, Gudrun, Steffan, Bärbel, Niering, Petra, Chovolou, Yvonni, Kampkötter, Andreas, Tran-Thi, Quynh-Hoa, Proksch, Peter, Kahl, Regine·2005·The Journal of Nutrition

DOI 10.1093/jn/135.3.525

Open this paper in CoChat — free account Open PDF

Abstract

Dietary flavonoids possess a wide spectrum of biochemical and pharmacological actions and are assumed to protect human health. These actions, however, can be antagonistic, and some health claims are mutually exclusive. The antiapoptotic actions of flavonoids may protect against neurodegenerative diseases, whereas their proapoptotic actions could be used for cancer chemotherapy. This study was undertaken to determine whether a cytoprotective dose range of flavonoids could be differentiated from a cytotoxic dose range. Seven structurally related flavonoids were tested for their ability to protect H4IIE rat hepatoma cells against H(2)O(2)-induced damage on the one hand and to induce cellular damage on their own on the other hand. All flavonoids proved to be good antioxidants in a cell-free assay. However, their pharmacologic activity did not correlate with in vitro antioxidant potential but rather with cellular uptake. For quercetin and fisetin, which were readily taken up into the cells, protective effects against H(2)O(2)-induced cytotoxicity, DNA strand breaks, and apoptosis were detected at concentrations as low as 10-25 micromol/L. On the other hand, these flavonoids induced cytotoxicity, DNA strand breaks, oligonucleosomal DNA fragmentation, and caspase activation at concentrations between 50 and 250 micromol/L. Published data on quercetin pharmacokinetics in humans suggest that a dietary supplement of 1-2 g of quercetin may result in plasma concentrations between 10 and 50 micromol/L. Our data suggest that cytoprotective concentrations of some flavonoids are lower by a factor of 5-10 than their DNA-damaging and proapoptotic concentrations.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/jn/135.3.525

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104
Antioxidant activity applying an improved ABTS radical cation decolorization assay
Re, R., Pellegrini, N., Proteggente, A. R., Pannala, A. S., Yang, M. H., & Rice-Evans, C. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00315-3 · Cited by 26,986
A simple technique for quantitation of low levels of DNA damage in individual cells
Singh, N. P., McCoy, M. T., Tice, R. R., & Schneider, E. L. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90265-0 · Cited by 10,828
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658
Review of the biology of quercetin and related bioflavonoids
Formica, J. V., & Regelson, W. (1995) · Food and Chemical Toxicology · doi:10.1016/0278-6915(95)00077-1 · Cited by 1,779
Flavonoid intake and risk of chronic diseases
Knekt, P., Kumpulainen, J. T., Järvinen, R., Rissanen, H. A., Heliövaara, M., Reunanen, A., Hakulinen, T., & Aromaa, A. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.3.560 · Cited by 1,765
Interactions of Flavonoids with Iron and Copper Ions: A Mechanism for their Antioxidant Activity
Mira, L., Fernandez, M. T., Santos, M., Rocha, R., Florêncio, M. H., & Jennings, K. R. (2002) · Free Radical Research · doi:10.1080/1071576021000016463 · Cited by 1,055
A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials
Draper, H. H., Squires, E. J., Mahmoodi, H., Wu, J., Agarwal, S., & Hadley, M. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90035-s · Cited by 916

Flagged first, then by citations

Show all 49 references

1 of the 49 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Wittig, 2000, Beta-glucuronidase activity in human endothelial tissues in an in-vitro model using primary monolayer cultures of human umbilical vein endothelial cells (HUVEC), Polyphenols Commun., 2, 459

Sorted by citations

Items 101–200 of 240

Pro-oxidative and Antioxidative Controls and Signaling Modification of Polyphenolic Phytochemicals: Contribution to Health Promotion and Disease Prevention?
Chu, K. O., Chan, S. O., Pang, C. P., & Wang, C. C. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf500080z · Cited by 38
Time‐course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells
Granado‐Serrano, A. B., Martín, M. Á., Bravo, L., Goya, L., & Ramos, S. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700203 · Cited by 35
Generating Biomedical Polyphenolic Compounds from Spent Coffee or Silverskin
Mussatto, S. I. (2014) · Coffee in Health and Disease Prevention · doi:10.1016/b978-0-12-409517-5.00011-5 · Cited by 35
Neuroprotective effect of bromelain in 6-hydroxydopamine induced in vitro model of Parkinson’s disease
Okkay, I. F., Okkay, U., Çiçek, B., Yılmaz, A., Yeşilyurt, F., Mendĭl, A. S., & Hacımüftüoğlu, A. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06779-y · Cited by 36
A quest for staunch effects of flavonoids: Utopian protection against hepatic ailments
Dhiman, A., Nanda, A., & Ahmad, S. (2012) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2012.05.001 · Cited by 37
Polyphenolic composition of extracts from winery by-products and effects on cellular cytotoxicity and mitochondrial functions in HepG2 cells
Fuchs, C., Bakuradze, T., Steinke, R., Grewal, R., Eckert, G. P., & Richling, E. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103988 · Cited by 34
The flavonoid (−)-epicatechin affects cytoskeleton proteins and functions in Entamoeba histolytica
Bolaños, V., Díaz-Martínez, A., Soto‐Sánchez, J., Rodríguez, M. A., López‐Camarillo, C., Marchat, L. A., & Ramírez‐Moreno, E. (2014) · Journal of Proteomics · doi:10.1016/j.jprot.2014.05.017 · Cited by 33
Harmonization of Mangiferin on methylmercury engendered mitochondrial dysfunction
Das, S., Paul, A., Mumbrekar, K. D., & Rao, B. S. S. (2016) · Environmental Toxicology · doi:10.1002/tox.22265 · Cited by 31
The citrus flavanone naringenin attenuates zymosan-induced mouse joint inflammation: induction of Nrf2 expression in recruited CD45+ hematopoietic cells
Bussmann, A. J. C., Borghi, S. M., Zaninelli, T. H., Saraiva‐Santos, T., Guazelli, C. F. S., Fattori, V., Domiciano, T. P., Pinho-Ribeiro, F. A., Ruiz-Miyazawa, K. W., Casella, A., et al. (2019) · Inflammopharmacology · doi:10.1007/s10787-018-00561-6 · Cited by 32
Phytochemical Constituents and Toxicity of Duguetia furfuracea Hydroalcoholic Extract in Drosophila melanogaster
Pinho, F. V. S. D. A., da Silva, G. F., Macedo, G. E., Müller, K. R., Martins, I. K., Ternes, A. P. L., da Costa, J. G. M., Athayde, M. L., Boligon, A. A., Kamdem, J. P., et al. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/838101 · Cited by 36
Potential of Kalanchoe pinnata as a Cancer Treatment Adjuvant and an Epigenetic Regulator
Hernández-Caballero, M. E., Sierra-Ramírez, J. A., Villalobos-Valencia, R., & Seseña, E. (2022) · Molecules · doi:10.3390/molecules27196425 · Cited by 31
Anticancer activity of flavonoids accompanied by redox state modulation and the potential for a chemotherapeutic strategy
Lee, Y.-K., Lee, J., & Lim, C. (2021) · Food Science and Biotechnology · doi:10.1007/s10068-021-00899-8 · Cited by 31
Strategies to Target Mitochondria and Oxidative Stress by Antioxidants: Key Points and Perspectives
Edeas, M. A. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0587-2 · Cited by 36
A Review on Anticancer Profile of Flavonoids: Sources, Chemistry, Mechanisms, Structure-activity Relationship and Anticancer Activity
Nayak, S. K., Shah, S., Narang, R., Singh, V. J., & Govindaiah, P. (2023) · Current Drug Research Reviews · doi:10.2174/2589977515666230120144852 · Cited by 28
Polyalthia longifolia Methanolic Leaf Extracts (PLME) induce apoptosis, cell cycle arrest and mitochondrial potential depolarization by possibly modulating the redox status in hela cells
Vijayarathna, S., Oon, C. E., Chen, Y., Kanwar, J. R., & Sasidharan, S. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.075 · Cited by 27
Fisetin Inhibits UVA-Induced Expression of MMP-1 and MMP-3 through the NOX/ROS/MAPK Pathway in Human Dermal Fibroblasts and Human Epidermal Keratinocytes
Jang, H., Kim, G.-B., Kim, J., Kang, S. Y., Youn, H.-J., Park, J., Ro, S. Y., Chung, E., Park, K., & Kim, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417358 · Cited by 27
pH-Sensitive Magnetite Nanoparticles Modified with Hyperbranched Polymers and Folic Acid for Targeted Imaging and Therapy
Rezaei, S. J. T., Malekzadeh, A. M., Ramazani, A., & Niknejad, H. (2019) · Current Drug Delivery · doi:10.2174/1567201816666191002102353 · Cited by 26
Fisetin targets phosphatidylinositol-3-kinase and induces apoptosis of human B lymphoma Raji cells
Lim, J. Y., Lee, J. Y., Byun, B. J., & Kim, S. H. (2015) · Toxicology Reports · doi:10.1016/j.toxrep.2015.07.004 · Cited by 26
Pterocarpans phaseollin and neorautenol isolated from Erythrina addisoniae induce apoptotic cell death accompanied by inhibition of ERK phosphorylation
Wätjen, W., Kulawik, A., Suckow-Schnitker, A.-K., Chovolou, Y., Rohrig, R., Ruhl, S., Kampkötter, A., Addae-Kyereme, J., Wright, C. W., & Passreiter, C. M. (2007) · Toxicology · doi:10.1016/j.tox.2007.09.010 · Cited by 26
Self-citation
Antioxidant and pro-oxidant effects of oil palm (Elaeis guineensis) leaves extract in experimental diabetic nephropathy: a duration-dependent outcome
Varatharajan, R., Sattar, M. Z. A., Chung, I., Abdulla, M. A., Kassim, N. M., & Abdullah, N. A. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-242 · Cited by 26
Role of Antioxidant Phytochemicals in Prevention, Formation and Treatment of Cancer
Koçyiğit, A., Güler, E. M., & Dikilitaş, M. (2018) · InTech eBooks · doi:10.5772/intechopen.72217 · Cited by 28
Effects of quercetin and menadione on intestinal calcium absorption and the underlying mechanisms
Marchionatti, A. M. E., Pacciaroni, A. D. V., & de Talamoni, N. G. T. (2012) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2012.09.007 · Cited by 25
Exogenous Antioxidants are Double-edged Swords
Koçyiğit, A., & Selek, Ş. (2016) · Bezmialem Science · doi:10.14235/bs.2016.704 · Cited by 25
The changes of antioxidant defense system caused by quercetin administration do not lead to DNA damage and apoptosis in the spleen and bone marrow cells of rats
Papiez, M. A., Cierniak, A., Krzyściak, W., Bzowska, M., Taha, H., Józkowicz, A., & Piskuła, M. K. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.06.006 · Cited by 25
Disturbance of redox status enhances radiosensitivity of hepatocellular carcinoma.
Sun, C., Wang, Z., Liu, X., Yang, L., Wang, Y., Liu, Y., Mao, A., Liu, Y.-Y., Zhou, X. H., Di, C., et al. (2015) · Europe PMC (PubMed Central) · Cited by 25
Biological Activity of Phenolics in Plant Cells
Bidel, L., Coumans, M., Baissac, Y., Doumas, P., & Jay‐Allemand, C. (2010) · doi:10.1002/9781444323375.ch6 · Cited by 25
In vitro activity of dietary flavonol congeners against human cancer cell lines
Tsimplouli, C., Demetzos, C., Hadzopoulou‐Cladaras, M., Pantazis, P., & DIMAS, K. S. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0204-5 · Cited by 24
The effects of Centella asiatica (L.) Urban on neural differentiation of human mesenchymal stem cells in vitro
Omar, N., Lokanathan, Y., Razi, Z. R. M., & Idrus, R. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2581-x · Cited by 23
Study of quercetin and fisetin synergistic effect on breast cancer and potentially involved signaling pathways
Hosseini, S. S., Ebrahimi, S. O., Kashani, M. H. G., & Reiisi, S. (2022) · Cell Biology International · doi:10.1002/cbin.11942 · Cited by 23
Short- and long-term exposure to low levels of pesticide and flavonoid mixtures modify endogenous antioxidants in tissues of rats
Panemangalore, M., & Bebe, F. N. (2009) · Journal of Environmental Science and Health Part B · doi:10.1080/03601230902801034 · Cited by 23
Isoquercitrin, isolated from Aster yomena triggers ROS-mediated apoptosis in Candida albicans
Yun, J., Woo, E., & Lee, D. G. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.01.041 · Cited by 22
Toxicological aspects ofCampomanesia xanthocarpaBerg. associated with its phytochemical profile
de Sousa, J. A., Prado, L. D. S., Alderete, B. L., Boaretto, F. B. M., Allgayer, M. C., Miguel, F. M., de Sousa, J. T., Marroni, N. P., Lemes, M. L. B., Corrêa, D. S., et al. (2019) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2018.1562392 · Cited by 22
Quercetin reduces chromosome aberrations induced by atrazine in theAllium cepatest
Mastrangelo, S., Tomassetti, M., Carratù, M. R., Evandri, M. G., & Bolle, P. (2006) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20199 · Cited by 22
The Underexplored Dimensions of Nutritional Hormesis
Pande, S., & Raisuddin, S. (2022) · Current Nutrition Reports · doi:10.1007/s13668-022-00423-2 · Cited by 22
ERK1/2 activation in quercetin-treated BEAS-2B cell plays a role in Nrf2-driven HO-1 expression
Lee, Y., Song, J.-H., Oh, M.-H., Lee, Y.-J., Kim, Y. B., Im, J.-H., & Lee, S.-H. (2011) · Molecular & Cellular Toxicology · doi:10.1007/s13273-011-0044-7 · Cited by 21
The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro
Demiroglu‐Zergeroglu, A., Basara, B., Kilic, E., & Demirel, G. Y. (2010) · BioMed Research International · doi:10.1155/2010/851589 · Cited by 21
Quercetin
Thangasamy, T., Sittadjody, S., & Burd, R. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374228-5.00027-5 · Cited by 20
Increased Expression of Catalase in Human Hepatoma Cells by the Soy Isoflavone, Daidzein
Kampkötter, A., Wiegand, C., Timpel, C., Röhrdanz, E., Chovolou, Y., Kahl, R., & Wätjen, W. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2007.00173.x · Cited by 20
Self-citation
Beneficial role of naringin against methotrexate-induced injury to rat testes: biochemical and ultrastructural analyses
Elsawy, H., Alzahrani, A. M., Alfwuaires, M. A., Abdel-Moneim, A. M., & Khalil, M. I. M. (2022) · Redox Report · doi:10.1080/13510002.2022.2101832 · Cited by 19
Quercetin Inhibits Diethylnitrosamine-Induced Hepatic Preneoplastic Lesions in Rats
Gupta, C., Tripathi, D. N., Vikram, A., Ramarao, P., & Jena, G. (2011) · Nutrition and Cancer · doi:10.1080/01635581.2011.523806 · Cited by 19
Biological activities and phenolic contents of Argania spinosa L (Sapotaceae) leaf extract
Dakiche, H., Khali, M., Abu-el-Haija, A. K., Almaaytah, A. M., & Al-Balas, Q. A. (2017) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v15i12.5 · Cited by 19
Maternal-fetal repercussions of Phyllanthus niruri L. treatment during rat pregnancy
Paula, V. G., da Cruz, L. L., Sene, L. D. B., Gratão, T. B., Soares, T. S., Moraes-Souza, R. Q., Damasceno, D. C., & Volpato, G. T. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112728 · Cited by 19
Quercetin acts as an antioxidant and downregulates CYP1A1 and CYP1B1 against DMBA-induced oxidative stress in mice
Choi, E. M. (2012) · Oncology Reports · doi:10.3892/or.2012.1753 · Cited by 19
Effect of photodynamic therapy supplemented with quercetin in HEp‐2 cells
Rodrigues, R. D. P., Tini, Í. R. P., Soares, C. P., & da Silva, N. S. (2014) · Cell Biology International · doi:10.1002/cbin.10251 · Cited by 18
An In Vitro Study of the Neurotoxic Effects of N-Benzylpiperazine: A Designer Drug of Abuse
Persona, K., Polus, A., Góralska, J., Gruca, A., Dembinska-Kiec, A., & Piekoszewski, W. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9604-x · Cited by 18
Antimutagenic and antioxidant properties of the aqueous extracts of organic and conventional grapevineVitis labruscacv. Isabella leaves in V79 cells
Trindade, C., Bortolini, G. V., Costa, B. S., Anghinoni, J. C., Guecheva, T. N., Arias, X., Cesio, M. V., Heinzen, H., Moura, D. J., Saffi, J., et al. (2016) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2016.1190675 · Cited by 17
Utilizing pathophysiological concepts of ischemia-reperfusion injury to design renoprotective strategies and therapeutic interventions for normothermic ex vivo kidney perfusion
Ogurlu, B., Hamelink, T. L., Tricht, I. M. V., Leuvenink, H. G. D., de Borst, M. H., Moers, C., & Pool, M. B. F. (2024) · American Journal of Transplantation · doi:10.1016/j.ajt.2024.01.001 · Cited by 17
Antioxidant effects of anthocyanins-rich extract from black sticky rice on human erythrocytes and mononuclear leukocytes
Sangkitikomol, W., Tencomnao, T., & Rocejanasaroj, A. (2010) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.4314/ajb.v9i48 · Cited by 17
Induction of DNA Double-Strand Breaks in the H4IIE Cell Line Exposed to Environmentally Relevant Concentrations of Copper, Cadmium, and Zinc, Singly and in Combinations
Haldsrud, R., & Kr⊘kje, Å. (2009) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390802538964 · Cited by 17
Redox Properties and Cytotoxicity of Synthetic Isomeric Mitochondriotropic Derivatives of the Natural Polyphenol Quercetin
Mattarei, A., Nicola Sassi, A., Durante, C., Biasutto, L., Sandonà, G., Marotta, E., Garbisa, S., Gennaro, A., Paradisi, C., & Zoratti, M. (2011) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201100573 · Cited by 17
Suppression of the Antioxidant System and PI3K/Akt/mTOR Signaling Pathway in Cisplatin-Resistant Cancer Cells by Quercetin
Hasan, A. A., Kalinina, E. V., Tatarskiy, V. V., Volodina, Y. L., Petrova, A. S., Novichkova, M., Zhdanov, D. D., & Shtil, A. A. (2022) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-022-05626-9 · Cited by 16
Potential anti-cancer activity of 7-O-pentyl quercetin: Efficient, membrane-targeted kinase inhibition and pro-oxidant effect
Nicola Sassi, A., Mattarei, A., Espina, V. A., Liotta, L. A., Zoratti, M., Paradisi, C., & Biasutto, L. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.07.016 · Cited by 17
Evaluation of licorice (Glycyrrhiza glabra L.) as a novel microgreen from the anti-inflammatory potential of polyphenols
Marotti, I., Truzzi, F., Tibaldi, C., Negri, L., & Dinelli, G. (2020) · AIMS Agriculture and Food · doi:10.3934/agrfood.2021001 · Cited by 15
Vicenin-2: a potential radiosensitizer of non-small cell lung cancer cells
Baruah, T. J., Sharan, R. N., & Kma, L. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4275-8 · Cited by 15
Flavonoid‐Like Components of Peanut Stem and Leaf Extract Promote Sleep by Decreasing Neuronal Excitability
Guo, R., Shi, A., Deng, L., Li, L., Wang, L., Oteng, A., Wei, M., Zhao, Z., Hooiveld, G. J. E. J., Zhang, C., et al. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100210 · Cited by 15
Cytoprotective and Cytotoxic Effects of Rice Bran Extracts in Rat H9c2(2‐1) Cardiomyocytes
Tan, X. W., Bhave, M. R., Fong, A. Y. Y., Matsuura, E., Kobayashi, K., Shen, L. H., & Hwang, S. S. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6943053 · Cited by 15
Quercetin-Induced Lifespan Extension in Podospora anserina Requires Methylation of the Flavonoid by the O-Methyltransferase PaMTH1
Warnsmann, V., Hainbuch, S., & Osiewacz, H. D. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00160 · Cited by 15
Comparison of the polyphenolic profile and antibacterial activity of the leaves, fruits and flowers of Rhododendron ambiguum and Rhododendron cinnabarinum
Shrestha, A., Rezk, A., Said, I. H., von Glasenapp, V., Smith, R. M., Ullrich, M. S., Schepker, H., & Kuhnert, N. (2017) · BMC Research Notes · doi:10.1186/s13104-017-2601-1 · Cited by 15
Review: Herbivory and the power of phytochemical diversity on animal health
Villalba, J. J., Ramsey, R. D., & Athanasiadou, S. (2024) · animal · doi:10.1016/j.animal.2024.101287 · Cited by 18
Pomegranate juice rescues developmental, neurobehavioral and biochemical disorders in aluminum chloride-treated male mice
Abu-Taweel, G. M., & Al-Mutary, M. G. (2020) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2020.126655 · Cited by 14
Influence of flavonoid extracts from celery on oxidative stress induced by dichlorvos in rats
Cao, J., Zhang, X., Wang, Q., Jia, L., Zhang, Y., & Zhao, X. (2011) · Human & Experimental Toxicology · doi:10.1177/0960327111426585 · Cited by 13
Relaxant Effects of Quercetin and Rutin on Human Isolated Bronchus
Djellili, H., Arrar, L., Naline, E., & Devillier, P. (2012) · Chinese Medicine · doi:10.4236/cm.2012.32015 · Cited by 13
Combination Approach: the Future of the War Against Cancer
Chen, L., & Malhotra, A. (2015) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-015-0549-0 · Cited by 12
Interactions between macromolecule-bound antioxidants and Trolox during liposome autoxidation: A multivariate approach
Çelik, E. E., Amigo, J. M., Andersen, M. L., & Gökmen, V. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.06.034 · Cited by 11
Alcohol consumption and hormonal alterations related to muscle hypertrophy: a review
Bianco, A., Thomas, E., Pomara, F., Tabacchi, G., Karsten, B., Paoli, A., & Palma, A. (2014) · Nutrition & Metabolism · doi:10.1186/1743-7075-11-26 · Cited by 11
Retracted
Flavonoids and Their Influence on the Gut Microbiome: Implications for Cardiovascular Health
Ahmadi, P., Honardoost, M., Janzadeh, A., & Taherkhani, S. (2026) · Nutrition Bulletin · doi:10.1111/nbu.70039 · Cited by 9
3-(4-methoxyphenyl) acrylic acid halts redox imbalance and modulate purinergic enzyme activity in iron-induced testicular injury
Ogunlakin, A. D., Adetunji, J. B., Iyobhebhe, M. E., Ajiboye, T. A., Gyebi, G. A., Ayeni, P. O., Ayokunle, D. I., Sonibare, M. A., ONOJA, J. O., Adesanya, E. O., et al. (2024) · Pure and Applied Chemistry · doi:10.1515/pac-2023-1201 · Cited by 9
Olive Leaf Extract as Natural Antioxidant Additive of Fresh Hamburger Stored at 4°C Running Title: Antioxidants from Olive Leaves in Hamburger
Al‐Rimawi, F., Tarawa, M. S. A. S., & Elama, C. (2017) · American journal of food science and technology · doi:10.12691/ajfst-5-4-7 · Cited by 9
Biosafety of Flavonoids in Rats: Effects on Copper and Zinc Homeostasis and Interaction with Low-Level Pesticide Exposure
Bebe, F. N., & Panemangalore, M. (2008) · Biological Trace Element Research · doi:10.1007/s12011-008-8289-2 · Cited by 9
Standardized Rhus verniciflua stokes extract and its major flavonoid fustin attenuate oxidative stress induced by tert-butyl hydroperoxide via activation of nuclear factor erythroid 2-related factor
Choi, Y. J., Min, G., Shin, J.-H., Kim, J. Y., & Kwon, O. (2014) · Journal of the Korean Society for Applied Biological Chemistry · doi:10.1007/s13765-013-4201-7 · Cited by 9
Alteration of the aortic vascular reactivity associated to excessive consumption of Hibiscus sabdariffa Linnaeus: Preliminary findings
Manzano-Pech, L., Guarner‐Lans, V., Soto, M. E., Díaz‐Díaz, E., & Pérez-Torres, I. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20020 · Cited by 8
Grape Wine and Tea Polyphenols in the Modulation of Atherosclerosis and Heart Disease
Omaye, S. T., & Dubick, M. A. (2006) · Modern nutrition · doi:10.1201/9781420006186.ch5 · Cited by 8
Atopic dermatitis-related anti-inflammatory in vitro effects of a plant extract mixture
Heinemann, N., Rademacher, F., Vollert, H., Gläser, R., & Harder, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-09053-4 · Cited by 7
Bioprospecting Davidson's plum and quandong: Cytoprotective and proapoptotic activities
Sakulnarmrat, K., Srzednicki, G., & Konczak, I. (2014) · LWT · doi:10.1016/j.lwt.2014.12.023 · Cited by 7
Grape juice concentrate modulates p16 expression in high fat diet-induced liver steatosis in Wistar rats
Ferreira, A. O., Gollücke, A. P. B., Noguti, J., da Silva, V. H. P., Yamamura, E. T. H., & Ribeiro, D. A. (2012) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2011.631196 · Cited by 7
Modulation of Multiple Pathways Involved in the Maintenance of Neuronal Function by Fisetin
Maher, P. A. (2009) · Oxidative stress and disease · doi:10.1201/9781420073522.ch14 · Cited by 7
Effect of grape juice on some biochemical and oxidative stress parameters in serum and liver enzymes of pregnant and lactating rats
Farias, M. T. D., Darío, R., Neto, B., & Dani, C. (2015) · Cited by 7
Fisetin: hormesis accounts for many of its chemoprotective effects
Calabrese, E. J., Pressman, P., Hayes, A. W., Agathokleous, E., Dhawan, G., Kapoor, R., Parmar, J., Mssillou, I., & Calabrese, V. (2025) · Biogerontology · doi:10.1007/s10522-025-10230-1 · Cited by 7
Cytotoxic and genotoxic action of Tagetes patula flower methanol extract and patuletin using the Allium test
Azhar, M., FAROOQ, A. D., Haque, S., Bano, S., ZAHEER, L., & Faizi, S. (2019) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1906-7 · Cited by 6
Polyphenol‑rich extract of Aronia melanocarpa inhibits TNF‑α induced apoptosis in H9c2 cells
Borecki, K., Żuchowski, M., Siennicka, A., Adler, G., & Jastrzebska, M. M. (2016) · Journal of Medical Science · doi:10.20883/jms.2016.119 · Cited by 6
A transcriptome based approach to predict candidate drug targets and drugs for Parkinson's disease using an in vitro 6-OHDA model
Yi̇ği̇t, E. N., Sönmez, E., Yüksel, İ., Kurnaz, I. A., & Çakır, T. (2022) · Molecular Omics · doi:10.1039/d2mo00267a · Cited by 6
The cytogenetic effects of silibinin alone and in combination with methotrexate in mouse bone marrow
Oufi, H. G. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.02.018 · Cited by 6
Carbon Monoxide-Releasing Activity of Plant Flavonoids
Lucie Muchova, A., Šranková, M., Balasubramani, S., Mehta, P., Vlachopoulou, D., Kapoor, A., Ramundo, A., Jézéquel, Y. A., Božek, I., Hurtová, M., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c09069 · Cited by 5
Evaluating the Effectiveness of Aqueous Extract of Persian Oak (Quercus castaneifolia C.A.Mey.) Fruit Hull on Dermal Wound Healing in the Rat Model
Malayeri, A., Golfakhrabadi, F., Basir, Z., Movahhed, T., & Abdevand, Z. Z. (2022) · Jundishapur Journal of Natural Pharmaceutical Products · doi:10.5812/jjnpp-127426 · Cited by 5
Oleuropein Stimulates Migration of Human Trophoblast Cells and Expression of Invasion-Associated Markers
Pirković, A., Krivokuća, M. J., Vilotić, A., Nacka-Aleksić, M., Bojić‐Trbojević, Ž., & Dekanski, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010500 · Cited by 5
Phytochemical Characterization, Prooxidant, Antiproliferative and Anti‐Inflammatory Potential of Meyna spinosa Roxb. Ex Link Ripe Fruit
Boruah, J. L. H., Gogoi, M., Famhawite, V., Barman, D., Das, D. J., Puro, N., Biswas, A., Mridha, P., Gogoi, P., Gajbhiye, R. L., et al. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202402342 · Cited by 5
Toxicological, biochemical and morphophysiological effects of Serjania erecta leaf aqueous extract on Piaractus mesopotamicus
Ventura, A. S., Filho, R. A. C. C., Spica, L. N., SILVA, A. C. F., Gabriel, A. M. D. A., Cardoso, C. A. L., Jerônimo, G. T., & Povh, J. A. (2021) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765202120190479 · Cited by 4
The Major Stilbene Compound Accumulated in the Roots of a Resistant Variety of Phoenix dactylifera L. Activates Proteasome for a Path in Anti-Aging Strategy
Benabbes, R., Ouahhoud, S., Moueqqit, M., Addi, M., Hano, C., Delporte, C., Nacoulma, A. P., & Mégalizzi, V. (2022) · Cells · doi:10.3390/cells12010071 · Cited by 4
Comparative Study of Condensed and Hydrolysable Tannins during the Early Stages of Zebrafish Development
Pietra, A. L., Imperatore, R., Coccia, E., Mobilio, T., Ferrandino, I., & Paolucci, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137063 · Cited by 4
Quercetin induces cell death by caspase-dependent and p38 MAPK pathway in EGFR mutant lung cancer cells
Lim, E. J., Heo, J., & Kim, Y.-H. (2016) · Kosin Medical Journal · doi:10.7180/kmj.2016.31.1.30 · Cited by 4
The Effect of Intrauterine Acute Ethanol Exposure on Developing Sciatic Nerves and Their Myelination: A Stereological Study
Aktaş, A., Turgut, M., Kaplan, S., Ulkay, M. B., Odacı, E., Akyüz, O., Çolakoğlu, S., Yazıcı, A. C., & Ince, O. (2009) · Journal of Experimental and Clinical Medicine · doi:10.5835/jecm.omu.26.01.003 · Cited by 4
The effects of blueberry anthocyanidins on antioxidant enzyme activity in human HepG2 cells
Galambos, A. R. (2012) · Cited by 4
Does Rainbow Trout Seminal Plasma-Cysteine Combination Affect the Cryo-Survivability and Post-Thaw Incubation Resilience of Ram Semen?
Gökçe, E., & Üstüner, B. (2022) · Biopreservation and Biobanking · doi:10.1089/bio.2022.0081 · Cited by 3
Natural Coumarins: QSTR Approaches Regarding Their Genotoxicity
Guardado, E., Matos, M. J., Uriarte, E., Santana, L., Guirado, O. A. A., & Molina, E. (2014) · International Electronic Conference on Synthetic Organic Chemistry (ECSOC) · doi:10.3390/ecsoc-18-e015 · Cited by 3
Cytoprotective Effect of Polyphenolic Compounds against Oxidative Stress in Cultured Retinal Pigment Epithelial Cells
Seo, K. H., Yu, S. Y., & Kwak, H. W. (2016) · Journal of the Korean Ophthalmological Society · doi:10.3341/jkos.2016.57.1.106 · Cited by 3
Protective Roles of Hop Proanthocyanidins on Alcohol-Induced SH-SY5Y Cell Damage
Dong, X., Zhang, X., Zhao, W., Nie, C., Li, Y., Li, Z., Zhai, N., Zhang, W., Mao, F., Ting, P. L.-P., et al. (2019) · Journal of the American Society of Brewing Chemists · doi:10.1080/03610470.2019.1686572 · Cited by 3
Differential Uridyl-diphosphate-Glucuronosyl Transferase 1A enzymatic arsenal explains the specific cytotoxicity of resveratrol towards tumor colorectal cells
Amintas, S., Beaumont, P., Dupin, C. L., Moranvillier, I., Lamrissi‐Garcia, I., Patel, E., Fernández, B., Bibeyran, A., Boutin, J., Richard, T., et al. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105345 · Cited by 3
Genotoxic effect of gallic and ellagic acids in somatic and germ cells of Drosophila melanogaster
Matic, S. D., Stanić, S., & Kanjevac, M. (2019) · Kragujevac Journal of Science · doi:10.5937/kgjsci1941069m · Cited by 2
Histopathological and Enzymological Evaluation of Opium Tincture and Protective Effects of Chicory Extract on Liver Structure in Adult Male Rats
Seyedebrahimi, R., Azimzadeh, M., Ababzadeh, S., Heidarieh, N., Bahrami, M., & Farsani, M. E. (2023) · Pharmaceutical Chemistry Journal · doi:10.1007/s11094-023-02896-z · Cited by 2
Effect of flavonoids and hyperthermal intraperitoneal chemotherapy on tumour growth and micronucleus induction in mouse tumour model
Oršolić, N., Sirovina, D., Krbavčić, M., & Car, N. (2013) · Human & Experimental Toxicology · doi:10.1177/0960327113499048 · Cited by 2

Authors: Wätjen, W., Michels, G., Steffan, B., Niering, P., Chovolou, Y., Kampkötter, A., Tran-Thi, Q.-H., Proksch, P., & Kahl, R.
Affiliations: Heinrich Heine University Düsseldorf (DE)
Corresponding author: Wätjen, Wim
ORCID: Wätjen, Wim
Chovolou, Yvonni
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2005-03
Volume: 135
Issue: 3
Pages: 525-531
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/135.3.525
OpenAlex: W1912855510
Cited by: 240
References: 49
Citations by year: 2026: 6 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 14 · 2021: 12 · 2020: 9 · 2019: 14 · 2018: 8 · 2017: 17 · 2016: 18 · 2015: 8 · 2014: 26 · 2013: 10 · 2012: 15
FWCI: 5.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6547 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords: flavonoids, quercetin, fisetin, H4IIE cells, hydrogen peroxide-induced cytotoxicity, DNA strand breaks, apoptosis, caspase activation, oligonucleosomal DNA fragmentation, cellular uptake, antioxidant activity, dose-dependent effects, cytoprotection, hepatoprotection, dietary flavonoids
MeSH terms: Animals, Cell Line, Cell-Free System, DNA Damage, Flavonoids, Carcinoma, Hepatocellular, Hydrogen Peroxide, Kinetics, Liver Neoplasms, Apoptosis, Cell Line, Tumor, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Low Concentrations of Flavonoids Are Protective in Rat H4IIE Cells Whereas High Concentrations Cause DNA Damage and Apoptosis,

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks