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Tumor Angiogenesis: A Quantitative Method for Histologic Grading 2
Abstract
A quantitative technique for measuring the degree of angiogenesis in tumors is described. The microscopic angiogenesis grading system was based on 3 parameters of endothelial regeneration: vasopro-liferation, endothelial cell hyperplasia, and endothelial cytology, providing a composite rating of 0–100. The method was tested in grading the degree of neovascularization in cerebral neoplasms and vascular tissues induced by tumors and tumor extracts; it appeared to give quantitatively reproducible and biologically reasonable results. Preliminary observations on a variety of other tumors suggest that solid neoplasms can be classified according to the extent of angiogenesis along a spectrum ranging from the “endothelial-poor” tumors, such as the chondrosarcomas, to the “endothelial-rich” tumors, such as glioblastomas.
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Citations
Cited by
Tumorigenesis and the angiogenic switch
Bergers, G., & Benjamin, L. E. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1093 · Cited by 3,559
Clinical translation of angiogenesis inhibitors
Kerbel, R., & Folkman, J. (2002) · Nature Reviews Cancer · doi:10.1038/nrc905 · Cited by 1,517
Hlatky, L. (2002) · CancerSpectrum Knowledge Environment · doi:10.1093/jnci/94.12.883 · Cited by 787
Weidner, N. (1995) · Breast Cancer Research and Treatment · doi:10.1007/bf00666038 · Cited by 718
FDA Drug Approval Summary: Bevacizumab (Avastin®) as Treatment of Recurrent Glioblastoma Multiforme
Cohen, M. H., Shen, Y. L., Keegan, P., & Pazdur, R. (2009) · The Oncologist · doi:10.1634/theoncologist.2009-0121 · Cited by 655
Metadata
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1972-02
- Volume
- 48
- Issue
- 2
- Pages
- 347-56
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W1917703525
- Cited by
- 414
- References
- 0
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tumor Angiogenesis: A Quantitative Method for Histologic Grading 2. (1972). JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/48.2.347
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