Cited by 3,559Angiogenesis and VEGF in CancerCancer Cells and MetastasisMathematical Biology Tumor Growth

Tumorigenesis and the angiogenic switch

Bergers, Gabriele, Benjamin, Laura E.·2003·Nature reviews. Cancer

Abstract

It has become evident that we cannot understand tumour growth without considering components of the stromal microenvironment, such as the vasculature. At the same time, the tumour phenotype determines the nature of the tumour vasculature. Much research is now devoted to determining the impact of angiogenesis on tumour development and progression, and the reciprocal influences of tumour products on the microvasculature. A more detailed understanding of the complex parameters that govern the interactions between the tumour and vascular compartments will help to improve anti-angiogenic strategies-- not only for cancer treatment, but also for preventing recurrence.

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Crossref · 10.1038/nrc1093

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111 of 111 references verified0 citation errors · 0 not checkable

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Authors
Bergers, G., & Benjamin, L. E.
Affiliations
  • University of California, San Francisco (US)
  • Beth Israel Deaconess Medical Center (US)
Corresponding author
Bergers, Gabriele
Venue
Nature reviews. Cancer
Published
2003-06
Volume
3
Issue
6
Pages
401-410
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2804842145
Cited by
3,559
References
110
Citations by year
2026: 53 · 2025: 79 · 2024: 123 · 2023: 122 · 2022: 142 · 2021: 160 · 2020: 149 · 2019: 159 · 2018: 162 · 2017: 176 · 2016: 148 · 2015: 176 · 2014: 232 · 2013: 223 · 2012: 198
FWCI
9.49
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
Keywords
carcinogenesis, angiogenic switch, tumor angiogenesis, tumor vasculature, tumor microenvironment, tumor-stroma interactions, tumor progression, anti-angiogenic therapy, tumor recurrence
MeSH terms
Animals, Humans, Neoplasms, Neovascularization, Pathologic, Disease Progression

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