Tumorigenesis and the angiogenic switch
Abstract
It has become evident that we cannot understand tumour growth without considering components of the stromal microenvironment, such as the vasculature. At the same time, the tumour phenotype determines the nature of the tumour vasculature. Much research is now devoted to determining the impact of angiogenesis on tumour development and progression, and the reciprocal influences of tumour products on the microvasculature. A more detailed understanding of the complex parameters that govern the interactions between the tumour and vascular compartments will help to improve anti-angiogenic strategies-- not only for cancer treatment, but also for preventing recurrence.
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Neovascularization represents a rate-limiting step in tumor progression.
“This neovascularization represents a rate-limiting step in tumor progression [47].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [47]
Some tumors co-opt existing vasculature and grow along the vessels until demand for nutrients and oxygen becomes too large and angiogenesis starts again.
“Instead of triggering angiogenesis, some tumors co-opt existing vasculature and grow along the vessels [53][54][55][56], until the demand for nutrients and oxygen becomes too large and angiogenesis starts again [53,55].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [55]
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- Authors
- Bergers, G., & Benjamin, L. E.
- Affiliations
- University of California, San Francisco (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Bergers, Gabriele
- ORCID
- Bergers, Gabriele
- Venue
- Nature reviews. Cancer
- Published
- 2003-06
- Volume
- 3
- Issue
- 6
- Pages
- 401-410
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2804842145
- Cited by
- 3,559
- References
- 110
- Citations by year
- 2026: 53 · 2025: 79 · 2024: 123 · 2023: 122 · 2022: 142 · 2021: 160 · 2020: 149 · 2019: 159 · 2018: 162 · 2017: 176 · 2016: 148 · 2015: 176 · 2014: 232 · 2013: 223 · 2012: 198
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Keywords
- carcinogenesis, angiogenic switch, tumor angiogenesis, tumor vasculature, tumor microenvironment, tumor-stroma interactions, tumor progression, anti-angiogenic therapy, tumor recurrence
- MeSH terms
- Animals, Humans, Neoplasms, Neovascularization, Pathologic, Disease Progression
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