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Inhibition of Carcinogenic and Toxic Effects of Polycyclic Hydrocarbons by Phenolic Anti-oxidants and Ethoxyquin 2
Abstract
The antioxidants butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and ethoxyquin inhibited the carcinogenicity of benzo[a]pyrene or 7,12-dimethylbenz[a]anthracene (DMBA) on the forestomach of the mouse. They also inhibited mammary tumor formation produced by oral administration of DMBA to female Sprague-Dawley rats. Alpha-tocopherol was ineffective in both the mouse and rat experiments. BHA and alpha-tocopherol did not suppress initiation of epidermal neoplasia in the mouse by DMBA. In 2 studies of the effects of antioxidants on DMBA toxicity, BHA decreased the lethality in mice of a high concentration of DMBA in the diet, and BHA, BHT, and ethoxyquin given to female rats 1 hour before oral administration of 30 mg DMBA prevented the adrenal necrosis occurring in animals not given the antioxidants.
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Cited by
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The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis
Yamamoto, M., Kensler, T. W., & Motohashi, H. (2018) · Physiological Reviews · doi:10.1152/physrev.00023.2017 · Cited by 1,968
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Baird, L., & Yamamoto, M. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00099-20 · Cited by 1,542
Benson, A. M., Hunkeler, M. J., & Talalay, P. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5216 · Cited by 746
Metadata
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1972-05
- Volume
- 48
- Issue
- 5
- Pages
- 1425-30
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W1947770363
- Cited by
- 342
- References
- 0
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Inhibition of Carcinogenic and Toxic Effects of Polycyclic Hydrocarbons by Phenolic Anti-oxidants and Ethoxyquin 2. https://app.cochat.ai/papers/10.1093/jnci/48.5.1425
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- Inhibition of Carcinogenic and Toxic Effects of Polycyclic Hydrocarbons by Phenolic Anti-oxidants and Ethoxyquin 2. (1972). JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/48.5.1425
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