The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.
Open accessAbstract
2(3)-tert-Butyl-4-hydroxyanisole (BHA) is one of several widely used antioxidant food additives that protect against chemical carcinogenesis and toxicity. The present report concerns the enhancement of dicoumarol-inhibited NAD(P)H:quinone reductase [NAD(P)H dehydrogenase (quinone); NAD(P)H:(quinone acceptor) oxidoreductase, EC 1.6.99.2] activity in mouse tissues in response to dietary administration of BHA. Cytosolic quinone reductase specific activity was increased significantly in 10 of 15 tissues examined from BHA-fed mice. The greatest proportionate increase, to 10 times control levels, was observed in liver. BHA also increased the quinone reductase activities of kidney, lung, and the mucosa of the upper small intestine severalfold. The increases of quinone reductase activities in liver and digestive tissues in response to BHA were comparable to the increases previously observed in glutathione S-transferase (EC 2.5.1.18) and epoxide hydratase (EC 3.3.2.3) activities. Quinones are among the toxic products of oxidative metabolism of aromatic hydrocarbons. NAD(P)H:quinone reductase exhibits broad specificity for structurally diverse hydrophobic quinones and may facilitate the microsomal metabolism of quinones to readily excreted conjugates. The protective effects of BHA appear to be due, at least in part, to the ability of this antioxidant to increase the activities in rodent tissues of several enzymes involved in the nonoxidative metabolism of a wide variety of xenobiotics.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.
Bachur, N. R., Gordon, S. L., Gee, M. V., & Kon, H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.2.954 · Cited by 489
Dt diaphorase I. Purification from the soluble fraction of rat-liver cytoplasm, and properties
Ernster, L., Danielson, L., & Ljunggren, M. (1962) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(62)90997-6 · Cited by 481
(1972) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/48.5.1425 · Cited by 342
Benson, A. M., Batzinger, R. P., Ou, S.-Y. L., Bueding, E., Cha, Y., & Talalay, P. (1978) · PubMed · Cited by 337
Self-citationInhibitors of Chemical Carcinogenesis
(1978) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60088-3 · Cited by 302
Haugen, D. A., Coon, M. J., & Nebert, D. W. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33722-5 · Cited by 227
Benson, A. M., Cha, Y. N., Bueding, E., Heine, H. S., & Talalay, P. (1979) · PubMed · Cited by 199
Self-citationWislocki, P. G., Wood, A. W., Rl, C., Levin, W., Yagi, H., Hernández, Ó., Dansette, P. M., Dm, H., & Conney, A. H. (1976) · PubMed · Cited by 160
Properties and Reaction Mechanism of DT Diaphorase from Rat Liver
Hosoda, S., Nakamura, W., & Hayashi, K. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42173-x · Cited by 158
Cited by
The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis
Yamamoto, M., Kensler, T. W., & Motohashi, H. (2018) · Physiological Reviews · doi:10.1152/physrev.00023.2017 · Cited by 1,968
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
Baird, L., & Yamamoto, M. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00099-20 · Cited by 1,542
Ramos-Gomez, M., Kwak, M.-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., & Kensler, T. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051618798 · Cited by 1,102
Self-citationSmall Molecule Modulators of Keap1‐ Nrf2‐ ARE Pathway as Potential Preventive and Therapeutic Agents
Magesh, S., Chen, Y., & Hu, L. (2012) · Medicinal Research Reviews · doi:10.1002/med.21257 · Cited by 760
The diverse functionality of NQO1 and its roles in redox control
Ross, D., & Siegel, D. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101950 · Cited by 499
Metadata
- Authors
- Benson, A. M., Hunkeler, M. J., & Talalay, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-09
- Volume
- 77
- Issue
- 9
- Pages
- 5216-5220
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2002314190
- Cited by
- 746
- References
- 32
- FWCI
- 11.68
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. https://app.cochat.ai/papers/10.1073/pnas.77.9.5216
- The paper
- Benson, A. M., Hunkeler, M. J., & Talalay, P. (1980). Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.9.5216
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
