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Induction of Estradiol Metabolism by Dietary Indole-3-carbinol in Humans
Abstract
Dietary indoles in cruciferous vegetables induce cytochrome P450 enzymes and have prevented tumors in various animal models. Because estradiol metabolism is also cytochrome P450 mediated and linked to breast cancer risk, indoles may similarly reduce estrogen-responsive tumors in humans. We examined several indoles in female Sprague-Dawley rats for induction of hepatic estradiol 2-hydroxylation. The most potent inducer, indole-3-carbinol, was administered to humans (500 mg daily for 1 wk). It significantly increased the extent (mean +/- SEM) of estradiol 2-hydroxylation from 29.3% +/- 2.1% to 45.6% +/- 2.1% (P less than .001). These results indicate that indole-3-carbinol strongly influences estradiol metabolism in humans and may provide a new chemopreventive approach to estrogen-dependent diseases.
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Citations
Cited by
Vegetables, fruit, and cancer. II. Mechanisms
Steinmetz, K. A., & Potter, J. D. (1991) · Cancer Causes and Control · doi:10.1007/bf00054304 · Cited by 804
Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies
Lampe, J. W. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.3.475s · Cited by 786
Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation
Hubbard, T. D., Murray, I. A., & Perdew, G. H. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.064246 · Cited by 640
Placebo-Controlled Trial of Indole-3-Carbinol in the Treatment of CIN
Bell, M. C., Crowley-Nowick, P., Bradlow, H. L., Sepkovic, D. W., Schmidt-Grimminger, D., Howell, P., Mayeaux, E. J., Tucker, A., Turbat-Herrera, E. A., & Mathis, J. M. (2000) · Gynecologic Oncology · doi:10.1006/gyno.2000.5847 · Cited by 262
Self-citationThe epidemiology of breast cancer
Kelsey, J. L., & Gammon, M. D. (1991) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.41.3.146 · Cited by 143
Metadata
- Authors
- Michnovicz, J. J., & Bradlow, H. L.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-06-06
- Volume
- 82
- Issue
- 11
- Pages
- 947-949
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W1981126660
- Cited by
- 181
- References
- 0
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Michnovicz, J. J., & Bradlow, H. L. (1990). Induction of Estradiol Metabolism by Dietary Indole-3-carbinol in Humans. JNCI Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/82.11.947
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
