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Effect of Tamoxifen on Serum Insulinlike Growth Factor I Levels in Stage I Breast Cancer Patients
Abstract
Insulinlike growth factor I (IGF-I) has been shown to be a potent mitogen for breast cancer cells in vitro, and IGF-I receptors have been demonstrated on human primary breast neoplasms. In a randomized, placebo-controlled study, we document that administration of the antiestrogen tamoxifen to patients with breast cancer was associated with a statistically significant (P = .002) reduction in the serum level of IGF-I. The mean IGF-I level was 1.4 U/mL in the placebo-treated group and 0.9 U/mL in the tamoxifen-treated group. Because serum IGF-I level is growth hormone (GH) dependent and because data suggest that the pubertal surge in GH and IGF-I levels is sex steroid dependent, we speculate that the mechanism underlying our observation may involve blockade by tamoxifen of estrogen action in the hypothalamic-pituitary axis. We conclude that tamoxifen treatment reduces IGF-I levels and that this reduction may contribute to the therapeutic effect of the drug.
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Cited by
Ma, J., Pollak, M. N., Giovannucci, E., Chan, J. M., Tao, Y., Hennekens, C. H., & Stampfer, M. J. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.7.620 · Cited by 1,119
Self-citationFisher, B., Anderson, S., Tan-Chiu, E., Wolmark, N., Wickerham, D. L., Fisher, E. R., Dimitrov, N. V., Atkins, J. N., Abramson, N., Merajver, S., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.4.931 · Cited by 272
Self-citationMetzger, D. L., & Kerrigan, J. R. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.2.8045971 · Cited by 152
Racial differences in premenopausal endogenous hormones
Pinheiro, S. P., Holmes, M. D., Pollak, M. N., Barbieri, R. L., & Hankinson, S. E. (2005) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0944 · Cited by 119
Self-citationInsulin receptor is an independent predictor of a favorable outcome in early stage breast cancer
Mulligan, A. M., O’Malley, F. P., Ennis, M., Fantus, I. G., & Goodwin, P. J. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9471-x · Cited by 96
Metadata
- Authors
- Pollak, M., Costantino, J., Polychronakos, C., Blauer, S.-A., Guyda, H., Redmond, C., Fisher, B., & Margolese, R.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-11-07
- Volume
- 82
- Issue
- 21
- Pages
- 1693-1697
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2097596862
- Cited by
- 259
- References
- 0
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effect of Tamoxifen on Serum Insulinlike Growth Factor I Levels in Stage I Breast Cancer Patients. https://app.cochat.ai/papers/10.1093/jnci/82.21.1693
- The paper
- Pollak, M., Costantino, J., Polychronakos, C., Blauer, S.-A., Guyda, H., Redmond, C., Fisher, B., & Margolese, R. (1990). Effect of Tamoxifen on Serum Insulinlike Growth Factor I Levels in Stage I Breast Cancer Patients. JNCI Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/82.21.1693
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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