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Helicobacter pylori Infection in Intestinal- and Diffuse-Type Gastric Adenocarcinomas
Abstract
Gastric cancer can be divided into two histologic types: intestinal and diffuse. To determine whether Helicobacter pylori, a bacterium linked with gastritis, was associated with either cancer type, we reviewed histologic sections from stomachs of patients who had undergone gastrectomy for gastric cancer. Of 37 of the sections with evidence of intestinal-type cancer, 33 (89.2%) contained H pylori in noncancerous tissue compared with 7 (31.8%) of 22 of the sections with evidence of diffuse-type cancer (odds ratio = 17.7; P less than .001). This association remained strong when controlled for age, sex, site, and number of sections reviewed. The prevalence of H pylori in intestinal-type gastric cancer far exceeded the prevalence of H pylori in diffuse disease and that described in the normal US population. This finding suggests that H pylori may be a cofactor in development of intestinal-type gastric cancer.
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Cited by
Helicobacter pylori infection induces gastric cancer in Mongolian gerbils
Watanabe, T., Tada, M., Nagai, H., Sasaki, S., & Nakao, M. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70143-x · Cited by 992
Global burden of gastric cancer: epidemiological trends, risk factors, screening and prevention
Thrift, A. P., Wenker, T. N., & El-Serag, H. B. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00747-0 · Cited by 828
Ernst, P. B., & Gold, B. D. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.615 · Cited by 554
Helicobacter pylori infection: Independent risk indicator of gastric adenocarcinoma
Hansson, L.-E., Engstrand, L., Nyrén, O., Evans, D. J., Lindgren, A., Bergström, R., Andersson, B., Athlin, L., Bendtsen, O., & Tracz, P. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90954-b · Cited by 272
Metadata
- Authors
- Parsonnet, J., Vandersteen, D., Goates, J., Sibley, R. K., Pritikin, J., & Chang, Y.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-05-01
- Volume
- 83
- Issue
- 9
- Pages
- 640-643
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2051705654
- Cited by
- 361
- References
- 0
- FWCI
- 29.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Parsonnet, J., Vandersteen, D., Goates, J., Sibley, R. K., Pritikin, J., & Chang, Y. (1991). Helicobacter pylori Infection in Intestinal- and Diffuse-Type Gastric Adenocarcinomas. JNCI Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/83.9.640
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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