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Cited by 992

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Helicobacter pylori infection induces gastric cancer in Mongolian gerbils

Open access
Watanabe, Takeshi, Tada, Mayumi, Nagai, Hirofumi, Sasaki, Satoshi, Nakao, Masafumi·1998·Gastroenterology
DOI 10.1016/s0016-5085(98)70143-x
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Abstract

BACKGROUND & AIMS Although epidemiological studies have indicated that Helicobacter pylori infection plays a crucial role in gastric carcinogenesis in humans, there is no direct proof that H. pylori is actually associated with gastric carcinogenesis. The purpose of this study was to elucidate the relationship between H. pylori infection and gastric carcinogenesis using an animal model of long-term H. pylori infection. METHODS Mongolian gerbils were orally inoculated with H. pylori, and the sequential morphological changes in the stomach were examined for up to 62 weeks. RESULTS H. pylori was constantly detected in all infected animals throughout the study. At the 26th week, severe active chronic gastritis, ulcers, and intestinal metaplasia could be observed in infected animals. By the end of the study, adenocarcinoma had developed in the pyloric region of 37% of the infected animals. All tumors consisted of well-differentiated intestinal-type epithelium, and their development seemed to be closely related to intestinal metaplasia. CONCLUSIONS We have successfully demonstrated that long-term infection with H. pylori induces adenocarcinoma in Mongolian gerbils. The observations are thus highly suggestive of the involvement of H. pylori infection in gastric carcinogenesis in humans.

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Metadata

Authors
Watanabe, T., Tada, M., Nagai, H., Sasaki, S., & Nakao, M.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1998-09
Volume
115
Issue
3
Pages
642-648
ISSN
0016-5085 (ISSN-L)
DOI
10.1016/s0016-5085(98)70143-x
OpenAlex
W2118522916
Cited by
992
References
26
FWCI
62.89
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. https://app.cochat.ai/papers/10.1016/s0016-5085(98)70143-x
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Watanabe, T., Tada, M., Nagai, H., Sasaki, S., & Nakao, M. (1998). Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Gastroenterology. https://doi.org/10.1016/s0016-5085(98)70143-x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.