The DOI matches its Crossref record.
Telomeres, Telomerase, and Immortality
Abstract
A current hypothesis gaining prominence proposes that activation of the enzyme telomerase is necessary for cells to become immortal, or capable of proliferating indefinitely. The theory suggests that almost all cancer cells must attain immortality for progression to malignant states and, hence, require activation of telomerase. This article reviews the function and formation of telomeres as background to evaluating the "telomere hypothesis." Experiments in support of and experiments that challenge the hypothesis are examined. Possible approaches to telomerase inhibition are discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Telomeres, telomerase, and aging: Origin of the theory
Olovnikov, A. M. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(96)00005-8 · Cited by 431
Anti-apoptotic Role of Telomerase in Pheochromocytoma Cells
Fu, W., Begley, J. G., Killen, M. W., & Mattson, M. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.7264 · Cited by 248
The Catalytic Subunit of Telomerase Protects Neurons Against Amyloid β‐Peptide‐Induced Apoptosis
Zhu, H., Fu, W., & Mattson, M. P. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750117.x · Cited by 175
Mitochondrial dynamics: orchestrating the journey to advanced age
Biala, A. K., Dhingra, R., & Kirshenbaum, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.04.015 · Cited by 82
Telomerase activity in ductal carcinoma in situ of the breast
Shpitz, B., Zimlichman, S., Zemer, R., Bomstein, Y., Zehavi, T., Liverant, S., Bernehim, J., Kaufman, Z., Klein, E., Shapira, Y., et al. (1999) · Breast Cancer Research and Treatment · doi:10.1023/a:1006394209922 · Cited by 46
Metadata
- Authors
- Rhyu, M. S.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-06-21
- Volume
- 87
- Issue
- 12
- Pages
- 884-894
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2169455407
- Cited by
- 380
- References
- 0
- FWCI
- 21.54
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Telomeres, Telomerase, and Immortality. https://app.cochat.ai/papers/10.1093/jnci/87.12.884
- The paper
- Rhyu, M. S. (1995). Telomeres, Telomerase, and Immortality. JNCI Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/87.12.884
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
