Mitochondrial dynamics: orchestrating the journey to advanced age

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

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Extension of murine life span by overexpression of catalase targeted to mitochondria

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Role of the INK4a Locus in Tumor Suppression and Cell Mortality

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Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition

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Oxygen, oxidative stress, hypoxia, and heart failure

Giordano, F. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24408 · Cited by 1,494 · see citing works

Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction

Chen, H., Chomyn, A., & Chan, D. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503062200 · Cited by 1,376 · cited 1× · see citing works

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

Chen, Y., & Dorn, G. W. (2013) · Science · doi:10.1126/science.1231031 · Cited by 1,323 · see citing works

Nix is a selective autophagy receptor for mitochondrial clearance

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Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction

Haigis, M. C., & Guarente, L. P. (2006) · Genes & Development · doi:10.1101/gad.1467506 · Cited by 1,295 · see citing works

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

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Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction

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The Mitochondrial Protein hFis1 Regulates Mitochondrial Fission in Mammalian Cells through an Interaction with the Dynamin-Like Protein DLP1

Yoon, Y., Krueger, E. W., Oswald, B. J., & McNiven, M. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5409-5420.2003 · Cited by 820 · see citing works

Properties of the Permeability Transition Pore in Mitochondria Devoid of Cyclophilin D

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Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury

Zhao, K., Zhao, G.-M., Wu, D., Soong, Y., Birk, A. V., Schiller, P. W., & Szeto, H. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402999200 · Cited by 782 · see citing works

Mitochondrial Morphology and Dynamics in Yeast and Multicellular Eukaryotes

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Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

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Calorie restriction and aging: review of the literature and implications for studies in humans

Heilbronn, L. K., & Ravussin, E. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.361 · Cited by 701 · see citing works

hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery

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Telomere length and replicative aging in human vascular tissues.

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Free Radical Theory of Aging: An Update: Increasing the Functional Life Span

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Tissue-specific regulation of SIRT1 by calorie restriction

Chen, D., Bruno, J., Easlon, E., Lin, S.-J., Cheng, H.-L., Alt, F. W., & Guarente, L. (2008) · Genes & Development · doi:10.1101/gad.1650608 · Cited by 567 · see citing works

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

Trifunovic, A., Hansson, A., Wredenberg, A., Rovio, A. T., Dufour, E., Khvorostov, I., Spelbrink, J. N., Wibom, R., Jacobs, H. T., & Larsson, N.-G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508886102 · Cited by 555 · see citing works

Oxidants in mitochondria: from physiology to diseases

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Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

Hafner, A. V., Dai, J., Gomes, A. P., Xiao, C., Palmeira, C. M., Rosenzweig, A., & Sinclair, D. A. (2010) · Aging · doi:10.18632/aging.100252 · Cited by 542 · see citing works

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

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Adriamycin-induced heart failure: mechanisms and modulation

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Mitochondria and Cardiovascular Aging

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Mitochondrial fission in apoptosis, neurodegeneration and aging

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The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

Jin, S. M., & Youle, R. J. (2013) · Autophagy · doi:10.4161/auto.26122 · Cited by 411 · see citing works

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

Lee, Y., Lee, H.-Y., Hanna, R. A., & Gustafsson, Å. B. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00368.2011 · Cited by 398 · see citing works

Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

Wohlgemuth, S. E., Seo, A. Y., Marzetti, E., Lees, H. A., & Leeuwenburgh, C. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2009.11.002 · Cited by 397 · see citing works

Sir2 Blocks Extreme Life-Span Extension

Fabrizio, P., Gattazzo, C., Battistella, L., Wei, M., Cheng, C., McGrew, K., & Longo, V. D. (2005) · Cell · doi:10.1016/j.cell.2005.08.042 · Cited by 388 · see citing works

Telomeres, Telomerase, and Immortality

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Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative Senescence of Endothelial Cells

Haendeler, J., Hoffmann, J., Diehl, J. F., Vasa‐Nicotera, M., Spyridopoulos, I., Zeiher, A. M., & Dimmeler, S. (2004) · Circulation Research · doi:10.1161/01.res.0000121104.05977.f3 · Cited by 382 · see citing works

Seven sirtuins for seven deadly diseases ofaging

Morris, B. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.525 · Cited by 380 · see citing works

Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure

Tanno, M., Kuno, A., Yano, T., Miura, T., Hisahara, S., Ishikawa, S., Shimamoto, K., & Horio, Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.090266 · Cited by 358 · see citing works

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

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Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation

Leri, A., Franco, S., Zacheo, A., Barlucchi, L., Chimenti, S., Limana, F., Nadal‐Ginard, B., Kajstura, J., Anversa, P., & Blasco, M. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg013 · Cited by 313 · see citing works

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

Chiara, F., Castellaro, D., Marin, O., Petronilli, V., Brusilow, W. S. A., Juhaszova, M., Sollott, S. J., Forte, M. A., Bernardi, P., & Rasola, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001852 · Cited by 291 · see citing works

A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy

Alavi, M. V., Bette, S. J., Schimpf, S., Schuettauf, F., Schraermeyer, U., Wehrl, H. F., Rüttiger, L., Beck, S. C., Tonagel, F., Pichler, B. J., et al. (2006) · Brain · doi:10.1093/brain/awm005 · Cited by 278 · see citing works

Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence

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Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1

Park, Y.-Y., Lee, S., Karbowski, M., Neutzner, A., Youle, R. J., & Cho, H. (2010) · Journal of Cell Science · doi:10.1242/jcs.061481 · Cited by 244 · see citing works

Mitochondrial dynamics and disease, OPA1

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Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway

Warboys, C. M., de Luca, A., Amini, N., Luong, L., Duckles, H., Hsiao, S., White, A., Biswas, S., Khamis, R., Chong, C. K., et al. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.303415 · Cited by 227 · see citing works

Contribution of Impaired Mitochondrial Autophagy to Cardiac Aging

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Physiological functions of mitochondrial fusion

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Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling

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Role of p14^ARF in Replicative and Induced Senescence of Human Fibroblasts

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Antioxidant Defenses in the Lung

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SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts

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Cellular Senescence, Vascular Disease, and Aging

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Dynamics of Mitochondrial DNA Nucleoids Regulated by Mitochondrial Fission Is Essential for Maintenance of Homogeneously Active Mitochondria during Neonatal Heart Development

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Effects of Age and Heart Failure on Human Cardiac Stem Cell Function

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The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice

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The Mitochondrial Dynamism-Mitophagy-Cell Death Interactome

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Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.

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Mitochondrial Contagion Induced by Parkin Deficiency in Drosophila Hearts and Its Containment by Suppressing Mitofusin

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Hypertension Induces Somatic Cellular Senescence in Rats and Humans by Induction of Cell Cycle Inhibitor p16 ^<i>INK4a</i>

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Superoxide Radical: Controversies, Contradictions, and Paradoxes

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Expression of Chr9p21 genes CDKN2B (p15), CDKN2A (p16, p14) and MTAP in human atherosclerotic plaque

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Contribution of p16 ^<i>INK4a</i> and p21 ^<i>CIP1</i> pathways to induction of premature senescence of human endothelial cells: permissive role of p53

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Cellular senescence in endothelial cells from atherosclerotic patients is accelerated by oxidative stress associated with cardiovascular risk factors

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MARF and Opa1 Control Mitochondrial and Cardiac Function in Drosophila

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Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction

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Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis

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A relative deficit in antioxidant reserve may contribute in cardiac failure.

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MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age

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Novel mechanisms in the treatment of heart failure: Inhibition of oxygen radicals and apoptosis by carvedilol

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Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging.

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Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging

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Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species

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Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice

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Myocardial Aging and Senescence: Where Have the Stem Cells Gone?

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Telomerase Activity in Rat Cardiac Myocytes is Age and Gender Dependent

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The Multifunctional Sorting Protein PACS-2 Regulates SIRT1-Mediated Deacetylation of p53 to Modulate p21-Dependent Cell-Cycle Arrest

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Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats

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p53 Mediates Autophagy and Cell Death by a Mechanism Contingent On Bnip3

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Two Close, Too Close

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Autophagy and mitophagy in the myocardium: therapeutic potential and concerns

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Mitochondrial Fission and Autophagy in the Normal and Diseased Heart

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SIRT1 in cardiovascular aging

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The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration

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Mathematical Modeling of the Role of Mitochondrial Fusion and Fission in Mitochondrial DNA Maintenance

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