The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Zinc Supplement Use and Risk of Prostate Cancer
Open accessAbstract
The high concentration of zinc in the prostate suggests that zinc may play a role in prostate health. We examined the association between supplemental zinc intake and prostate cancer risk among 46 974 U.S. men participating in the Health Professionals Follow-Up Study. During 14 years of follow-up from 1986 through 2000, 2901 new cases of prostate cancer were ascertained, of which 434 cases were diagnosed as advanced cancer. Supplemental zinc intake at doses of up to 100 mg/day was not associated with prostate cancer risk. However, compared with nonusers, men who consumed more than 100 mg/day of supplemental zinc had a relative risk of advanced prostate cancer of 2.29 (95% confidence interval = 1.06 to 4.95; P(trend) =.003), and men who took supplemental zinc for 10 or more years had a relative risk of 2.37 (95% confidence interval = 1.42 to 3.95; P(trend)<.001). Although we cannot rule out residual confounding by supplemental calcium intake or some unmeasured correlate of zinc supplement use, our findings, that chronic zinc oversupply may play a role in prostate carcinogenesis, warrant further investigation.
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Cites
Rimm, E. B., Giovannucci, E. L., Stampfer, M. J., Colditz, G. A., Litin, L. B., & Willett, W. C. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116211 · Cited by 2,104
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Cited by
The Essential Toxin: Impact of Zinc on Human Health
Plum, L. M., Rink, L., & Haase, H. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7041342 · Cited by 1,577
Zinc requirements and the risks and benefits of zinc supplementation
Maret, W., & Sandstead, H. H. (2006) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2006.01.006 · Cited by 1,119
Zinc deficiency, DNA damage and cancer risk
Ho, E. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.07.005 · Cited by 518
Hsing, A. (2006) · Frontiers in Bioscience · doi:10.2741/1891 · Cited by 447
Effects of zinc supplementation on diabetes mellitus: A systematic review and meta-analysis
Jayawardena, R., Ranasinghe, P., Galappatthy, P., Malkanthi, R., Constantine, G., & Katulanda, P. (2012) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-4-13 · Cited by 346
Metadata
- Authors
- Leitzmann, M. F., Stampfer, M. J., Wu, K., Colditz, G. A., Willett, W. C., & Giovannucci, E. L.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-07-02
- Volume
- 95
- Issue
- 13
- Pages
- 1004-1007
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2138783705
- Cited by
- 307
- References
- 1
- FWCI
- 14.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Leitzmann, M. F., Stampfer, M. J., Wu, K., Colditz, G. A., Willett, W. C., & Giovannucci, E. L. (2003). Zinc Supplement Use and Risk of Prostate Cancer. JNCI Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/95.13.1004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
