The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Ductal Carcinoma In Situ, Complexities and Challenges
Abstract
The incidence of ductal carcinoma in situ (DCIS), a noninvasive form of breast cancer, has increased markedly in recent decades, and DCIS now accounts for approximately 20% of breast cancers diagnosed by mammography. Laboratory and patient data suggest that DCIS is a precursor lesion for invasive cancer. The appropriate classification of DCIS has provoked much debate; a number of classification systems have been developed, but there is a lack of uniformity in the diagnosis and prognostication of this disease. Further investigation of molecular markers should improve the classification of DCIS and our understanding of its relationship to invasive disease. Controversy also exists with regard to the optimal management of DCIS patients. In the past, mastectomy was the primary treatment for patients with DCIS, but as with invasive cancer, breast-conserving surgery has become the standard approach. Three randomized trials have reported a statistically significant decrease in the risk of recurrence with radiation therapy in combination with lumpectomy compared with lumpectomy alone, but there was no survival advantage with the addition of radiotherapy. Two randomized trials have suggested an additional benefit, in terms of recurrence, with the addition of adjuvant tamoxifen therapy, although in one trial the benefit was not statistically significant. Current data suggest that tamoxifen use should be restricted to patients with estrogen receptor-positive DCIS. Neither trial demonstrated a survival benefit with adjuvant tamoxifen. Ongoing and recently completed studies should provide information on outcomes in patients treated with lumpectomy alone and on the effectiveness of aromatase inhibitors as an alternative to tamoxifen.
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Unraveling the microenvironmental influences on the normal mammary gland and breast cancer
Weigelt, B., & Bissell, M. J. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.03.013 · Cited by 273
Soria, G., Yaal-Hahoshen, N., Azenshtein, E., Shina, S., Leider-Trejo, L., Ryvo, L., Cohen-Hillel, E., Shtabsky, A., Ehrlich, M., Meshel, T., et al. (2008) · Cytokine · doi:10.1016/j.cyto.2008.08.002 · Cited by 92
Vibrational spectroscopic mapping and imaging of tissues and cells
Carter, E. A., Tam, K. K., Armstrong, R. S., & Lay, P. A. (2009) · Biophysical Reviews · doi:10.1007/s12551-009-0012-9 · Cited by 41
The shifting nature of women’s experiences and perceptions of ductal carcinoma in situ
Kennedy, F., Harcourt, D., & Rumsey, N. (2012) · Journal of Advanced Nursing · doi:10.1111/j.1365-2648.2011.05788.x · Cited by 20
Metadata
- Authors
- Leonard, G. D., & Swain, S. M.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-06-15
- Volume
- 96
- Issue
- 12
- Pages
- 906-920
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2126717458
- Cited by
- 386
- References
- 97
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- closed
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