The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Persistent Organochlorine Pesticides and Risk of Testicular Germ Cell Tumors
Abstract
BACKGROUND: Exposure to endocrine-disrupting chemicals, such as persistent organochlorine pesticides, has been suggested to increase the risk of testicular germ cell tumors (TGCTs). METHODS: To study the relationship of POP exposure to TGCT risk, prediagnostic serum samples from 754 case subjects and 928 control subjects enrolled in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study were analyzed for cis-nonachlor, trans-nonachlor, oxychlordane, total chlordanes, beta-hexachlorocyclohexane, mirex, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), and p,p'-dichlorodiphenyltrichloroethane. Adjusted odds ratios (ORs) and their associated 95% confidence intervals (CIs) for the risk of TGCT overall and for the histological subgroups, seminoma and nonseminoma, were estimated using multivariable logistic regression. All statistical tests were two-sided. RESULTS: TGCT risk was statistically significantly associated with higher plasma levels of p,p'-DDE (for highest quartile [Q4] vs lowest quartile [Q1], OR = 1.71, 95% CI = 1.23 to 2.38, P(trend) = .0002) and of two chlordane components, cis-nonachlor (Q4 vs Q1, OR = 1.56, 95% CI = 1.11 to 2.18, P(trend) = .009) and trans-nonachlor (Q4 vs Q1, OR = 1.46, 95% CI = 1.07 to 2.00, P(trend) = .026). Seminoma risk was statistically significantly associated with p,p'-DDE (Q4 vs Q1, OR = 1.91, 95% CI = 1.22 to 2.99, P(trend) = .0008), cis-nonachlor (Q4 vs Q1, OR = 1.93, 95% CI = 1.27 to 2.93, P(trend) = .0045), trans-nonachlor (Q4 vs Q1, OR = 1.72, 95% CI = 1.11 to 2.67, P(trend) = .033), and a chlordane metabolite, oxychlordane (Q4 vs Q1, OR = 1.64, 95% CI = 1.04 to 2.60, P(trend) = .048), whereas nonseminoma risk showed a statistically significant association with p,p'-DDE only (Q4 vs Q1, OR = 1.63, 95% CI = 1.10 to 2.42, P(trend) = .0044). CONCLUSIONS: Increased exposure to p,p'-DDE may be associated with the risk of both seminomatous and nonseminomatous TGCTs, whereas exposure to chlordane compounds and metabolites may be associated with the risk of seminoma. Because evidence suggests that TGCT is initiated in very early life, it is possible that exposure to these persistent organic pesticides during fetal life or via breast feeding may increase the risk of TGCT in young men.
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Male Reproductive Health and Environmental Xenoestrogens
Toppari, J., Larsen, J. C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L. J., Jegou, B., Jensen, T. K., Jouannet, P., Keiding, N., et al. (1996) · Environmental Health Perspectives · doi:10.2307/3432709 · Cited by 348
Invited commentary: why DDT matters now
Longnecker, M. P. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi277 · Cited by 65
Cited by
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Sule, R. O., Condon, L., & Gomes, A. V. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5563759 · Cited by 573
The Pine River statement: human health consequences of DDT use
Eskenazi, B., Chevrier, J., Rosas, L. G., Anderson, H. A., Bornman, M. S., Bouwman, H., Chen, A., Cohn, B. A., de Jager, C., Henshel, D. S., et al. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.11748 · Cited by 333
Bonde, J. P., Flachs, E. M., Rimborg, S., Glazer, C. H., Giwercman, A., Ramlau-Hansen, C. H., Hougaard, K. S., Høyer, B. B., Hærvig, K. K., Petersen, S. B., et al. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw036 · Cited by 304
Impacts of endocrine disrupting chemicals on reproduction in wildlife and humans
Marlatt, V. L., Bayen, S., Castaneda-Cortès, D., Delbès, G., Grigorova, P., Langlois, V. S., Martyniuk, C. J., Metcalfe, C. D., Parent, L., Rwigemera, A., et al. (2022) · Environmental Research · doi:10.1016/j.envres.2021.112584 · Cited by 280
Metadata
- Authors
- McGlynn, K. A., Quraishi, S. M., Graubard, B. I., Weber, J.-P., Rubertone, M. V., & Erickson, R. L.
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-05-07
- Volume
- 100
- Issue
- 9
- Pages
- 663-671
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2106420207
- Cited by
- 210
- References
- 2
- FWCI
- 16.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- McGlynn, K. A., Quraishi, S. M., Graubard, B. I., Weber, J.-P., Rubertone, M. V., & Erickson, R. L. (2008). Persistent Organochlorine Pesticides and Risk of Testicular Germ Cell Tumors. JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/djn101
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