The DOI matches its Crossref record; 220 of the 220 references it cites were found in a registry or an index.
A Common Feature of Pesticides: Oxidative Stress—The Role of Oxidative Stress in Pesticide‐Induced Toxicity
Open accessAbstract
Pesticides are important chemicals or biological agents that deter or kill pests. The use of pesticides has continued to increase as it is still considered the most effective method to reduce pests and increase crop growth. However, pesticides have other consequences, including potential toxicity to humans and wildlife. Pesticides have been associated with increased risk of cardiovascular disease, cancer, and birth defects. Labels on pesticides also suggest limiting exposure to these hazardous chemicals. Based on experimental evidence, various types of pesticides all seem to have a common effect, the induction of oxidative stress in different cell types and animal models. Pesticide‐induced oxidative stress is caused by both reactive oxygen species (ROS) and reactive nitrogen species (RNS), which are associated with several diseases including cancer, inflammation, and cardiovascular and neurodegenerative diseases. ROS and RNS can activate at least five independent signaling pathways including mitochondrial‐induced apoptosis. Limited in vitro studies also suggest that exogenous antioxidants can reduce or prevent the deleterious effects of pesticides.
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Cites
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“Recent evidence also suggests that ROS function as important physiological regulators of intracellular signaling pathways [31].”
BackgroundWorldwide pesticide usage and its impacts on ecosystem
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Cited by
Ahmad, M. F., Ahmad, F. A., Alsayegh, A. A., Zeyaullah, M., AlShahrani, A. M., Muzammil, K., Saati, A. A., Wahab, S., Elbendary, E. Y., Kambal, N., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29128 · Cited by 624
RetractedFocus on the Contribution of Oxidative Stress in Skin Aging
Papaccio, F., D′Arino, A., Caputo, S., & Bellei, B. (2022) · Antioxidants · doi:10.3390/antiox11061121 · Cited by 396
RONS and Oxidative Stress: An Overview of Basic Concepts
Aranda-Rivera, A. K., Cruz-Gregorio, A., Arancibia-Hernández, Y. L., Hernández-Cruz, E. Y., & Pedraza-Chaverri, J. (2022) · Oxygen · doi:10.3390/oxygen2040030 · Cited by 384
Dumitru, C. N., Mariana, L., Budacu, C. C., Mitea, G., Radu, M. D., Dumitru, A. O., Lupoae, A., Tatu, A., & Topor, G. (2025) · Dentistry Journal · doi:10.3390/dj13050222 · Cited by 17
Metadata
- Authors
- Sule, R. O., Condon, L., & Gomes, A. V.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2022-01
- Volume
- 2022
- Issue
- 1
- Pages
- 5563759-5563759
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W4205604443
- Cited by
- 573
- References
- 220
- FWCI
- 54.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sule, R. O., Condon, L., & Gomes, A. V. (2022). A Common Feature of Pesticides: Oxidative Stress—The Role of Oxidative Stress in Pesticide‐Induced Toxicity. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2022/5563759
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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