Cited by 830Cancer survivorship and careChildhood Cancer Survivors' Quality of LifeWomen's cancer prevention and management

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

Quality of Life, Fertility Concerns, and Behavioral Health Outcomes in Younger Breast Cancer Survivors: A Systematic Review

Howard-Anderson, J., Ganz, P. A., Bower, J. E., Stanton, A. L.·2012·JNCI Journal of the National Cancer Institute

DOI 10.1093/jnci/djr541

Open this paper in CoChat — free account

Abstract

BACKGROUND: Breast cancer is the most common cancer in women younger than age 50 years. Cancer treatments in younger women may cause premature menopause, infertility, and negative psychosocial effects. In this systematic review, we examined three key domains of functioning that are particularly relevant for younger breast cancer survivors: health-related quality of life (QOL), menopausal symptoms and fertility concerns, and behavioral health outcomes. METHODS: We conducted a literature review using PubMed and secondary sources and examined 840 articles published between January 1990 and July 2010. Inclusion criteria for articles were 1) published in English after 1989; 2) exclusively analyzed female breast cancer survivors aged 50 years or younger or premenopausal at diagnosis, with baseline characteristics and/or quantitative or descriptive analyses for this age group; 3) investigated QOL (health-related QOL including physical functioning and mental health, depression, and anxiety), menopause- or fertility-related concerns, and weight gain or physical activity-related behavioral health outcomes. Data were extracted using a standardized table collecting the purpose, design, population, and results of each study. Extracted data were reviewed for accuracy by two investigators and presented as descriptive tables. RESULTS: A total of 28 articles met the inclusion criteria (15 cross-sectional studies, eight longitudinal studies, and five randomized trials). Regarding data review, no discordance between investigators was noted. Standardized measures of QOL and depressive symptoms identified worse outcomes as being more frequent or severe in breast cancer survivors aged 50 years or younger when compared with the general age-matched population of women without cancer and to older women (aged >50 years) with breast cancer. Concerns about premature menopause, menopausal symptoms, and infertility were common in younger women (aged ≤ 50 years) and had a role in the level of distress after treatment. Weight gain and physical inactivity were common health outcomes in younger women. CONCLUSIONS: Younger women with breast cancer were found to experience distinct psychosocial and menopause-related concerns, weight gain, and physical inactivity. A need for more longitudinal research, including efforts at intervention to manage these symptoms and adverse health outcomes, remains.

Integrity signals

Registry

Crossref · 10.1093/jnci/djr541

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cancer Statistics, 2010
Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20073 · Cited by 12,596
Untitled work
(1994) · Medical Entomology and Zoology · Cited by 4,156
Effect of Screening and Adjuvant Therapy on Mortality from Breast Cancer
Berry, D. A., Cronin, K. A., Plevritis, S. K., Fryback, D. G., Clarke, L. D., Zelen, M., Mandelblatt, J. S., Yakovlev, A. Y., Habbema, J. D. F., & Feuer, E. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050518 · Cited by 2,456
Center for Epidemiologic Studies Depression Scale (CES-D) as a screening instrument for depression among community-residing older adults.
Lewinsohn, P. M., Seeley, J. R., Roberts, R. E., & Allen, N. B. (1997) · Psychology and Aging · doi:10.1037/0882-7974.12.2.277 · Cited by 1,782
Physical activity and survival after breast cancer diagnosis
Holmes, M. D. (2005) · JAMA · doi:10.1001/jama.293.20.2479 · Cited by 1,772
Future of Cancer Incidence in the United States: Burdens Upon an Aging, Changing Nation
Smith, B. D., Smith, G. L., Hurria, A., Hortobágyi, G. N., & Buchholz, T. A. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.8983 · Cited by 1,733
Life after breast cancer: understanding women's health-related quality of life and sexual functioning.
Ganz, P. A., Rowland, J. H., Desmond, K., Meyerowitz, B. E., & Wyatt, G. E. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.2.501 · Cited by 962
Self-citation
Body image and sexual problems in young women with breast cancer
Fobair, P., STEWART, S. L., Chang, S., D’Onofrio, C. N., Banks, P. J., & Bloom, J. R. (2005) · Psycho-Oncology · doi:10.1002/pon.991 · Cited by 888
Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer
Hershman, D. L., Shao, T., Kushi, L. H., Buono, D., Tsai, W. Y., Fehrenbacher, L., Kwan, M., Gomez, S. L., & Neugut, A. I. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1132-4 · Cited by 870
Early Discontinuation and Nonadherence to Adjuvant Hormonal Therapy in a Cohort of 8,769 Early-Stage Breast Cancer Patients
Hershman, D. L., Kushi, L. H., Shao, T. H., Buono, D. L., Kershenbaum, A., Tsai, W., Fehrenbacher, L., Gomez, S. L., Miles, S. Q., & Neugut, A. I. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.9655 · Cited by 834

Show all 99 references

Research works printed but not linked: 7

1994, JNCI Monographs, 1994, 191
1994, JNCI Monographs, 1994, 1
1999, CANCER RES THER CONTROL, 8, 93
2000, Acta oncol gica, 39, 959
2009, Cancer nursing, 32, 247
2010, 51, 112
Chlebowski, 2002, Journal of Clinical Oncology, 20, 1128, 10.1200/JCO.20.4.1128 · DOI

Sorted by citations

Items 201–300 of 829

Life Satisfaction, Body Image and Associated Factors among Women with Breast Cancer after Mastectomy
Phoosuwan, N., & Lundberg, P. C. (2023) · Psycho-Oncology · doi:10.1002/pon.6106 · Cited by 33
“Younger women receiving mastectomy were associated with greater body image concerns.(12,13) After mastectomy, women commonly choose breast reconstruction because they want”
Background
When life gives you lemons: The effectiveness of culinary group intervention among cancer patients
Barak-Nahum, A., Haim, L. B., & Ginzburg, K. (2016) · Social Science & Medicine · doi:10.1016/j.socscimed.2016.07.046 · Cited by 33
Observational study of the development and evaluation of a fertility preservation patient decision aid for teenage and adult women diagnosed with cancer: the Cancer, Fertility and Me research protocol
Jones, G. L., Hughes, J., Mahmoodi, N., Greenfield, D., Brauten‐Smith, G., Skull, J., Gath, J., Yeomanson, D., Baskind, E., Snowden, J. A., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-013219 · Cited by 33
Medical costs associated with metastatic breast cancer in younger, midlife, and older women
Trogdon, J. G., Baggett, C. D., Gogate, A., Reeder-Hayes, K. E., Rotter, J., Zhou, X., Ekwueme, D. U., Fairley, T. L., & Wheeler, S. B. (2020) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-05654-x · Cited by 33
The impact of chronic comorbidities at the time of breast cancer diagnosis on quality of life, and emotional health following treatment in Canada
Arneja, J., & Brooks, J. D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256536 · Cited by 33
“Conversely, greater social support [13], and support satisfaction [14] have a positive impact on QOL.”
Background
Cancer survivorship in low- and middle-income countries: challenges, needs, and emerging support strategies
dos Anjos, G. R., Machado, G. F., de Barros, C. P., de Andrade, V. P., Maciel, R. M. B., & Cunha, L. L. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1601483 · Cited by 38
An Investigative Study into Psychological and Fertility Sequelae of Gestational Trophoblastic Disease: The Impact on Patients’ Perceived Fertility, Anxiety and Depression
Mattei, V. E. D., Carnelli, L., Bernardi, M., Bagliacca, E. P., Zucchi, P., Lavezzari, L., Giorgione, V., Ambrosi, A., Mangili, G., Candiani, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128354 · Cited by 32
Factors associated with health-related quality of life in a cohort of Spanish breast cancer patients
Valdezate, D. M., Buch, E., Peiró, S., Morales-Monsalve, M. D., Gárate, A. C., Martínez-Agulló, Á., Ayet, F. C., & Ortega, J. (2012) · Breast Cancer · doi:10.1007/s12282-012-0402-x · Cited by 36
Preserving fertility in young women undergoing chemotherapy for early breast cancer; the Maastricht experience
Vriens, I. J. H., Butalid, E. T. W. , de Boer, M., de Die-Smulders, C. E. M., Derhaag, J. G., Geurts, S. M. E., van Hellemond, I. E. G., Luiten, E. J. T., Dercksen, M. W., Lemaire, B. M. D., et al. (2020) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-05598-2 · Cited by 32
Depression, anxiety, and their associated factors among Chinese early breast cancer in women under 35 years of age: A cross sectional study.
Lan, B., Jiang, S.-Y., Li, T., Sun, X.-Y., & Ma, F. (2020) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2020.100558 · Cited by 30
Breast cancer treatment costs in younger, privately insured women
Allaire, B. T., Ekwueme, D. U., Poehler, D. C., Thomas, C. C., Guy, G. P., Subramanian, S., & Trogdon, J. G. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4249-x · Cited by 32
“These side effects can include poorer quality of life, fertility problems, and depression [9, 10].”
Symptoms: Menopause, Infertility, and Sexual Health
Barton, D. L., & Ganz, P. A. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-16366-6_9 · Cited by 31
Self-citation
Psychosocial factors associated with quality of life in cancer survivors: umbrella review
Voskanyan, V., Marzorati, C., Sala, D., Grasso, R., Pietrobon, R. S., van der Heide, I., Engelaar, M., Bos, N., Caraceni, A. T., Couespel, N., et al. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05749-8 · Cited by 35
“Specifically, greater social support and satisfaction with social support have a positive influence on QoL (Howard-Anderson et al. 2012; Wen et al. 2014), whereas lack of social support contributes to reduced QoL (Bours et al. 2016).”
BackgroundInfluential
Searching for metastases in ovarian tissue before autotransplantation: a tailor-made approach
Hoekman, E. J., Smit, V. T. H. B. M., Fleming, T. P., Louwe, L. A., Fleuren, G. J., & Hilders, C. G. J. M. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.11.001 · Cited by 31
Sleep difficulty mediates effects of vasomotor symptoms on mood in younger breast cancer survivors
Vincent, A. J., Ranasinha, S., Sayakhot, P., Mansfield, D. R., & Teede, H. J. (2014) · Climacteric · doi:10.3109/13697137.2014.900745 · Cited by 31
Health‐related quality of life before and after head and neck squamous cell carcinoma: Analysis of the Surveillance, Epidemiology, and End Results–Medicare Health Outcomes Survey linkage
Rettig, E. M., DʼSouza, G., Thompson, C. B., Koch, W. M., Eisele, D. W., & Fakhry, C. (2016) · Cancer · doi:10.1002/cncr.30005 · Cited by 31
“The growing appreciation that HRQOL is paramount to improved cancer survivorship care is manifested by a growing literature of rigorous HRQOL evaluation in prostate and breast cancer survivors.(2,3) HRQOL is particularly important in the current era of head and neck cancer, because the incidence of new diagnoses among…”
Background
Life satisfaction of women of working age shortly after breast cancer surgery
Olsson, M., Nilsson, M. I., Fugl-Meyer, K. S., Petersson, L., Wennman‐Larsen, A., Kjeldgård, L., & Alexanderson, K. A. E. (2017) · Quality of Life Research · doi:10.1007/s11136-016-1479-z · Cited by 30
“However, although there are several quality-of-life studies of breast cancer patients internationally [5, 18, 19], life satisfaction shortly after breast cancer surgery has, to the best of our knowledge, hitherto only been the focus of one small study of breast cancer patients [20], in which chemotherapy showed strong…”
Background
Development and Validation of a Fertility Intention Scale in Breast Cancer Survivors
Li, C.-C., Huang, S., Lai, J. C., Hsiung, Y., Chen, Y., & Lee, C. (2017) · Journal of Nursing Research · doi:10.1097/jnr.0000000000000223 · Cited by 30
Young Women With Breast Cancer: Treatment, Care, and Nursing Implications
Corey, B., Smania, M. A., Spotts, H., & Andersen, M. (2020) · Clinical journal of oncology nursing · doi:10.1188/20.cjon.139-147 · Cited by 30
Depression and Health-Related Quality of Life Among Young Adult Breast Cancer Patients: The Mediating Role of Reproductive Concerns
Bártolo, A., Santos, I. M., Valério, E., & Monteiro, S. O. M. (2020) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2019.0144 · Cited by 30
“11,12 However, other issues related to their own health after a potential pregnancy and the genetic risk to their offspring also worry cancer patients.”
Posttraumatic stress in breast cancer survivors diagnosed at a young age
Vazquez, D. A., Rosenberg, S. M., Gelber, S. I., Ruddy, K. J., Morgan, E., Recklitis, C. J., Come, S. E., Schapira, L., & Partridge, A. H. (2020) · Psycho-Oncology · doi:10.1002/pon.5438 · Cited by 30
Treatment-related amenorrhea in a modern, prospective cohort study of young women with breast cancer
Poorvu, P. D., Hu, J., Zheng, Y. H., Gelber, S. I., Ruddy, K. J., Tamimi, R. M., Peppercorn, J. M., Schapira, L., Borges, V. F., Come, S. E., et al. (2021) · npj Breast Cancer · doi:10.1038/s41523-021-00307-8 · Cited by 31
The Psychological Distress and Quality of Life of Breast Cancer Survivors in Sydney, Australia
Aitken, L.-A., & Hossan, S. Z. (2022) · Healthcare · doi:10.3390/healthcare10102017 · Cited by 30
“Those aged younger than 50 years are especially likely to report psychological distress [15,16] compared to the older cohort aged > 50 years.”
Background
Efficacy of a web-based women’s health survivorship care plan for young breast cancer survivors: a randomized controlled trial
Su, H.-C. I., Stark, S. S., Kwan, B., Boles, S. G., Chingos, D. T., Ehren, J. L., Gorman, J. R., Krychman, M., Romero, S. A. D., Mao, J. J. J., et al. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05260-6 · Cited by 30
Adjuvant endocrine therapy uptake, toxicity, quality of life, and prediction of early discontinuation
Balazard, F., Bertaut, A., Bordet, É., Mulard, S., Blanc, J., Briot, N., Paux, G., Mérimèche, A. D., Rigal, O., Coutant, C., et al. (2023) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djad109 · Cited by 32
Unique Aspects of Caring for Young Breast Cancer Patients
Ferzoco, R. M., & Ruddy, K. J. (2015) · Current Oncology Reports · doi:10.1007/s11912-014-0425-x · Cited by 29
Neurological complications of breast cancer: study protocol of a prospective cohort study
Pereira, S., Fontes, F., Sonin, T., Dias, T., Fragoso, M., Castro‐Lopes, J. M., & Lunet, N. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-006301 · Cited by 29
The quality of life of Croatian women after mastectomy: a cross-sectional single-center study
Pačarić, S., Kristek, J., Mirat, J., Kondža, G., Turk, T., Farčić, N., Orkić, Ž., & Nemčić, A. (2018) · BMC Public Health · doi:10.1186/s12889-018-5929-0 · Cited by 29
Potential Mechanisms of Ovarian Protection with Gonadotropin-Releasing Hormone Agonist in Breast Cancer Patients: A Review
Poggio, F. B., Lambertini, M., Bighin, C., Conte, B., Blondeaux, E., D’Alonzo, A., Dellepiane, C., Buzzatti, G., Molinelli, C., Boccardo, F., et al. (2019) · Clinical Medicine Insights Reproductive Health · doi:10.1177/1179558119864584 · Cited by 29
Productivity costs associated with metastatic breast cancer in younger, midlife, and older women
Trogdon, J. G., Liu, X., Reeder‐Hayes, K. E., Rotter, J., Ekwueme, D. U., & Wheeler, S. B. (2020) · Cancer · doi:10.1002/cncr.33077 · Cited by 29
Fertility under uncertainty: exploring differences in fertility-related concerns and psychosocial aspects between breast cancer survivors and non-cancer infertile women
Bártolo, A., Neves, M. C., Carvalho, B. G., Reis, S., Valério, E., Santos, I. M., & Monteiro, S. O. M. (2020) · Breast Cancer · doi:10.1007/s12282-020-01124-w · Cited by 29
Microablative Fractional CO2 Laser for Vulvovaginal Atrophy in Women With a History of Breast Cancer: A Pilot Study at 4-week Follow-up
Salvatore, S., Nappi, R. E., Casiraghi, A., Ruffolo, A. F., Degliuomini, R. S., Parma, M., Maggiore, U. L. R., Athanasiou, S., & Candiani, M. (2021) · Clinical Breast Cancer · doi:10.1016/j.clbc.2021.01.006 · Cited by 29
A review of factors affecting patient fertility preservation discussions & decision-making from the perspectives of patients and providers
Daly, C., Micic, S., Facey, M. E., Speller, B., Yee, S., Kennedy, E. D., Corter, A. L., & Baxter, N. N. (2018) · European Journal of Cancer Care · doi:10.1111/ecc.12945 · Cited by 29
“Thematic analysis was conducted to iden‐ tify barriers and facilitators to FP decision‐making (Kastner et al., 2012).”
Fertility, sexuality and cancer in young adult women
Condorelli, M., Lambertini, M., Mastro, L. D., Boccardo, F., Demeestere, I., & Bober, S. L. (2019) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000540 · Cited by 29
“The development of treatment-induced premature ovarian insufficiency (POI) is associated with a variety of negative health-related consequences including infertility and sexual dysfunction [5].”
Background
Longitudinal changes of health-related quality of life over 10 years in breast cancer patients treated with radiotherapy following breast-conserving surgery
Gao, Y., Rosas, J. C., Fink, H., Behrens, S., Chang-Claude, J. C., & Seibold, P. (2023) · Quality of Life Research · doi:10.1007/s11136-023-03408-y · Cited by 28
Breast Cancer and Fertility Preservation in Young Female Patients: A Systematic Review of the Literature
Boutas, I., Kontogeorgi, A., Koufopoulos, N. I., Dimas, D., Sitara, K., Kalantaridou, S., & Dimitrakakis, C. (2023) · Clinics and Practice · doi:10.3390/clinpract13060127 · Cited by 28
“For a patient diagnosed with breast cancer at a young age, fertility and pregnancy issues that might arise during treatment contribute to their emotional and psychological distress [7].”
Background
How medical choices influence quality of life of women carrying a BRCA mutation
Harmsen, M. G., Hermens, R., Prins, J. B., Hoogerbrugge, N., & de Hullu, J. A. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.07.010 · Cited by 28
The Quality and Readability of Online Consumer Information About Gynecologic Cancer
Sobota, A., & Özakinci, G. (2015) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000000362 · Cited by 28
“For women who were diagnosed with cancer during their reproductive years, resolving their fertility issues might be a salient part of the rehabilitation process.(9,10) In view of the existing literature, we decided to assess the quality and readability of the content of frequently accessed gynecologic cancer-related W…”
Background
Performance status and depressive symptoms as predictors of quality of life in cancer patients. A structural equation modeling analysis
Faller, H., Brähler, E., Härter, M. C., Keller, M., Schulz, H., Wegscheider, K., Weis, J., Boehncke, A., Richard, M., Sehner, S., et al. (2015) · Psycho-Oncology · doi:10.1002/pon.3811 · Cited by 28
A Randomized, Placebo-Controlled Trial Evaluating Changes in Peripheral Neuropathy and Quality of Life by Using Low-Frequency Electrostimulation on Breast Cancer Patients Treated With Chemotherapy
Song, S.-Y., Park, J.-H., Lee, J. S., Kim, J. R., Sohn, E. H., Jung, M. S., & Yoo, H. (2020) · Integrative Cancer Therapies · doi:10.1177/1534735420925519 · Cited by 28
Moderators of inflammation-related depression: a prospective study of breast cancer survivors
Manigault, A. W., Ganz, P. A., Irwin, M. R., Cole, S. W., Kuhlman, K. R., & Bower, J. E. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01744-6 · Cited by 29
“Younger survivors (<50) are at the highest risk for depression following breast cancer diagnosis and treatment [76], and the present results could serve to characterize this trend.”
BackgroundSelf-citation
Validity of a single-item indicator of treatment side effect bother in a diverse sample of cancer patients
Griffiths, P. L., Peipert, J. D., Leith, A., Rider, A., Morgan, L., Cella, D. F., & Cocks, K. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-06802-3 · Cited by 28
“Treatment side effects reduce health-related quality of life (HRQoL) among cancer survivors, especially during and directly after treatment [10, 11].”
Background
The Impact of Psychiatric Diagnoses on Patient-reported Satisfaction and Quality of Life in Postmastectomy Breast Reconstruction
Shamsunder, M. G., Chu, J. J., Polanco, T. O., Yin, S., Costas-Muñíz, R., James, M. C., Mehrara, B. J., Pusic, A. L., Voineskos, S. H., & Nelson, J. A. (2022) · Annals of Surgery · doi:10.1097/sla.0000000000005478 · Cited by 28
“Data Source and Study Population An institutional review board–approved study (18-202) was performed to evaluate patient-reported outcomes in postmastectomy reconstruction patients (a component of routine clinical care).”
Method
Approaches to Fertility Preservation for Young Women With Breast Cancer
Razeti, M. G., Soldato, D., Arecco, L., Levaggi, A., Puglisi, S., Solinas, C., Agostinetto, E., Spinaci, S., Lapuchesky, L. S., Genova, C., et al. (2023) · Clinical Breast Cancer · doi:10.1016/j.clbc.2023.01.006 · Cited by 35
The Late Effects of Cancer Treatment on Female Fertility and the Current Status of Fertility Preservation—A Narrative Review
Rodriguez‐Wallberg, K. A., Jiang, Y., Lekberg, T., & Nilsson, H. (2023) · Life · doi:10.3390/life13051195 · Cited by 29
“However, many young cancer survivors will develop late effects of their treatment, causing a lifelong impact on mental and physical health, negatively affecting the quality of life [4,5].”
Background
Cost–utility analysis of individual psychosocial support interventions for breast cancer patients in a randomized controlled study
Arving, C., Brandberg, Y., Feldman, I., Johansson, B., & Glimelius, B. L. G. (2013) · Psycho-Oncology · doi:10.1002/pon.3411 · Cited by 28
Predictors of psychological distress in breast cancer survivors: A biopsychosocial approach
Pérez-Tejada, J., Labaka, A., Pascual‐Sagastizábal, E., Garmendia, L., Iruretagoyena, A., & Arregi, A. (2019) · European Journal of Cancer Care · doi:10.1111/ecc.13166 · Cited by 29
Patients' experiences following breast cancer treatment: an exploratory survey of personal and work experiences of breast cancer patients from three European countries
Braybrooke, J. P., Mimoun, S., Zarca, D., Elia, D., Pinder, B., Lloyd, A., Breheny, K., Lomazzi, M., & Borisch, B. (2014) · European Journal of Cancer Care · doi:10.1111/ecc.12222 · Cited by 27
Predicting Ovarian Activity in Women Affected by Early Breast Cancer: A Meta-Analysis-Based Nomogram.
Barnabei, A., Strigari, L., Marchetti, P., Sini, V., de Vecchis, L., Corsello, S., & Torino, F. (2015) · The Oncologist · doi:10.1634/theoncologist.2015-0183 · Cited by 28
Psychometric properties of the Chinese version of the Reproductive Concerns After Cancer Scale (RCAC) for young female cancer survivors
Qiao, T.-T., Zheng, W., Xing, W., Zhang, L., Zhang, W., Shi, Y., & Chen, X. (2016) · Supportive Care in Cancer · doi:10.1007/s00520-016-3519-1 · Cited by 28
“emotional distress after treatment [9].”
Advances in Fertility Preservation for Young Women With Cancer
Smith, K. L., Gracia, C. R., Sokalska, A., & Moore, H. C. F. (2018) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_208301 · Cited by 27
Partners of young breast cancer survivors: a cross-sectional evaluation of psychosocial concerns, coping, and mental health
Borstelmann, N. A., Rosenberg, S. M., Gelber, S. I., Zheng, Y. H., Meyer, M. E., Ruddy, K. J., Schapira, L., Come, S. E., Borges, V. F., Cadet, T. J., et al. (2020) · Journal of Psychosocial Oncology · doi:10.1080/07347332.2020.1823546 · Cited by 27
An Improved Stress-Scale Specifically Designed to Measure Stress of Women with Newly Diagnosed Breast Cancer
Lee, T., Hsing, S.-C., & Li, C.-C. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18052346 · Cited by 30
“Additionally, some studies have demonstrated that breast cancer patients under the age of 50 suffer a greater psychological burden than older patients, and that the psychological burden does not improve over time [21,22].”
Background
Adherence to Dietary Recommendations after One Year of Intervention in Breast Cancer Women: The DIANA-5 Trial
Bruno, E., Krogh, V., Gargano, G., Grioni, S., Bellegotti, M., Venturelli, E., Panico, S., de Magistris, M. S., Bonanni, B., Zagallo, E., et al. (2021) · Nutrients · doi:10.3390/nu13092990 · Cited by 27
“In detail, premature menopause is a consequence of chemotherapy and/or hormonal treatment, and it is accompanied by physiologic changes that can affect energy balance, with a consequent increase in abdominal fat, reduction in lean mass, and worsening of MS parameters [21].”
Background
Quality of life in female cancer survivors: is it related to ovarian reserve?
Kondapalli, L. A., Dillon, K., Sammel, M. D., Ray, A., Prewitt, M., Ginsberg, J. P., & Gracia, C. R. (2013) · Quality of Life Research · doi:10.1007/s11136-013-0473-y · Cited by 27
“organs are impacted by cancer therapy, and may result in impaired psychosocial and sexual functioning [2, 3].”
Background
Couplelinks - an online intervention for young women with breast cancer and their male partners: study protocol for a randomized controlled trial
Fergus, K. D., Ahmad, S., McLeod, D. L., Stephen, J. E., Gardner, S. L., Pereira, A., Warner, E., & Carter, W. (2015) · Trials · doi:10.1186/s13063-014-0534-8 · Cited by 28
“These unique challenges may include: the loss of fertility and therefore a loss of the choice to conceive children [2,4,11,13,14]; not having children because of the fear that pregnancy-related hormonal changes may provoke a cancer recurrence [15]; premature menopause with its associated hot flashes, and sleep and moo…”
Background
Post-treatment problems of African American breast cancer survivors
Barsevick, A. M., Leader, A. E., Bradley, P. K., Avery, T. P., Dean, L. T., DiCarlo, M. A., & Hegarty, S. (2016) · Supportive Care in Cancer · doi:10.1007/s00520-016-3359-z · Cited by 27
“With regard to age, a review of 28 studies of younger survivors (younger than age 51) identified menopause and infertility as key issues [16].”
Background
“I don't want to take chances.”: A qualitative exploration of surgical decision making in young breast cancer survivors
Rosenberg, S. M., Greaney, M. L., Patenaude, A. F., Sepucha, K., Meyer, M. E., & Partridge, A. H. (2018) · Psycho-Oncology · doi:10.1002/pon.4683 · Cited by 27
Does access to an information-based, breast cancer specific website help to reduce distress in young women with breast cancer? Results from a randomised trial
WHITE, V. M., Farrelly, A., Pitcher, M. E., & Hill, D. (2018) · European Journal of Cancer Care · doi:10.1111/ecc.12897 · Cited by 27
The sleep response to stress: how sleep reactivity can help us prevent insomnia and promote resilience to trauma
Reffi, A. N., Kalmbach, D. A., Cheng, P., & Drake, C. L. (2023) · Journal of Sleep Research · doi:10.1111/jsr.13892 · Cited by 25
Biopsychosocial correlates of adjustment to cancer during chemotherapy: the key role of health-related quality of life
Lauriola, M., & Tomai, M. (2019) · The Scientific World JOURNAL · doi:10.1155/2019/9750940 · Cited by 26
The relationship among body image, psychological distress, and quality of life in young breast cancer patients: a cross-sectional study
Yao, H., Xiong, M., Cheng, Y.-P., Zhang, Q., Luo, Y., Ding, X., & Zhang, C. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1411647 · Cited by 26
The Childbearing Concerns and Related Information Needs and Preferences of Women of Reproductive Age with a Chronic, Noncommunicable Health Condition: A Systematic Review
Holton, S., Kirkman, M., Rowe, H. J., & Fisher, J. (2012) · Women s Health Issues · doi:10.1016/j.whi.2012.08.001 · Cited by 26
Utility of GnRH-Agonists for Fertility Preservation in Women with Operable Breast Cancer: Is It Protective?
Bedoschi, G., Turan, V., & Oktay, K. (2013) · Current Breast Cancer Reports · doi:10.1007/s12609-013-0123-y · Cited by 26
“Concerns about premature ovarian failure and infertility were common in younger breast cancer survivors and had a role in the level of distress after treatment [3].”
Background
Lifestyle intervention for Latina cancer survivors and caregivers: the Nuestra Salud randomized pilot trial
Crane, T. E., Badger, T. A., O’Connor, P., Segrin, C. G., Alvarez, A. A., Freylersythe, S. G., Penaloza, I., Pace, T. W. W., & Sikorskii, A. E. (2020) · Journal of Cancer Survivorship · doi:10.1007/s11764-020-00954-z · Cited by 26
“Many symptoms last up to 10 years after completion of cancer treatment [26, 27].”
Background
New onset of type 2 diabetes as a complication after cancer diagnosis: A systematic review
Jo, A., Scarton, L. J., O’Neal, L. J., Larson, S. A., Schafer, N., George, T. J., & Pena, J. M. M. (2020) · Cancer Medicine · doi:10.1002/cam4.3666 · Cited by 26
“The study included: (1) cohort studies, (2) cancer diagnosis by a doctor, (3) incidence”
Method
Anxiety and depression after breast cancer: The predictive role of monoamine levels
Pérez-Tejada, J., Labaka, A., Vegas, Ó., Larraioz, A., Pescador, A., & Arregi, A. (2021) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2021.101953 · Cited by 33
Breast Cancer Survivors and Healthy Women: Could Gut Microbiota Make a Difference?—“BiotaCancerSurvivors”: A Case-Control Study
Caleça, T., Ribeiro, P., Vitorino, M. M., Menezes, M., Sampaio-Alves, M., Mendes, A. D., Vicente, R. S., Negreiros, I., Faria, A., & Costa, D. A. (2023) · Cancers · doi:10.3390/cancers15030594 · Cited by 26
Chemotherapy-Related Amenorrhea and Quality of Life Among Premenopausal Women With Breast Cancer
Kabirian, R., Franzoi, M. A., Havas, J., Coutant, C., Trédan, O., Lévy, C., Cottu, P. H., Mérimèche, A. D., Guillermet, S., Ferrero, J.-., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.43910 · Cited by 26
Effectiveness of group psycho-education on well-being and depression among breast cancer survivors of Melaka, Malaysia
Barua, A., Ram, S., & Narayanasamy, R. (2013) · Indian Journal of Palliative Care · doi:10.4103/0973-1075.110234 · Cited by 26
“Howard‑Anderson et al ., [35] found self-esteem significantly affected the quality of life of young breast cancer women.”
Breast cancer survivors' perceived medical communication competence and satisfaction with care at the end of treatment
Brédart, A., Kop, J., Fiszer, C., Sigal‐Zafrani, B., & Dolbeault, S. (2015) · Psycho-Oncology · doi:10.1002/pon.3836 · Cited by 37
“Moreover, their quality of life is often more severely impaired compared with older (>50 years old) BCS [43].”
Background
Breast Cancer in Young Women
Trogdon, J. G., Ekwueme, D. U., Chamiec‐Case, L., & Guy, G. P. (2016) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2015.09.026 · Cited by 26
Review of fertility preservation issues for young women with breast cancer
Gonçalves, V., & Quinn, G. P. (2016) · Human Fertility · doi:10.1080/14647273.2016.1193228 · Cited by 26
“…fertility issues are particularly important and pertinent for these young women (Avis, Crawford, & Manuel, 2004; Gonçalves, Sehovic, & Quinn, 2014; Howard-Anderson et al., 2012; Morrow et al., 2014; Partridge et al., 2004; Peate, Meiser, Hickey, & Friedlander, 2009; Senkus et al., 2014) and…”
Identifying distinct trajectories of change in young breast cancer survivors' sexual functioning
von Hippel, C. D., Rosenberg, S. M., Austin, S. B., Sprunck‐Harrild, K., Ruddy, K. J., Schapira, L., Come, S. E., Borges, V. F., & Partridge, A. H. (2019) · Psycho-Oncology · doi:10.1002/pon.5047 · Cited by 26
“Young women treated with chemotherapy and endocrine therapy often face early menopausal symptoms like hot flashes and distressing concerns about infertility.(10,11,18) These effects may make sex emotionally or physically painful and cause many young women to lose interest in sexual activity, decrease activity, and dev…”
Background
Rasch Analysis of the 9-Item Shared Decision Making Questionnaire in Women With Breast Cancer
Wu, T., Chen, C.-T., Huang, Y., Hou, W., Wang, J., & Hsieh, C. (2018) · Cancer Nursing · doi:10.1097/ncc.0000000000000607 · Cited by 26
Differences in symptom clusters before and twelve months after breast cancer surgery
Mazor, M. B., Cataldo, J. K., Lee, K. A., Dhruva, A., Cooper, B. A., Paul, S. M., Topp, K. S., Smoot, B. J., Dunn, L. B., Levine, J. D., et al. (2017) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2017.12.003 · Cited by 25
“Prior to and following breast cancer treatment women experience multiple co-occurring menopausal-related symptoms (Barton and Ganz, 2015; Howard-Anderson et al., 2012).”
BackgroundInfluential
Radiation therapy for young women with early breast cancer: Current state of the art
Meattini, I., Lambertini, M., Desideri, I., Caluwé, A. D., Kaidar‐Person, O., & Livi, L. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.02.014 · Cited by 25
Quality of life in pre- and postmenopausal patients with early breast cancer: a comprehensive analysis from the prospective MaLife project
The TMK-Group (Tumour Registry Breast Cancer), Marschner, N. W., Trarbach, T., Rauh, J., Meyer, D., Müller‐Hagen, S., Harde, J., Dille, S., Kruggel, L., & Jänicke, M. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05197-w · Cited by 25
Adherence to Guidelines for Cancer Survivors and Health-Related Quality of Life among Korean Breast Cancer Survivors
Song, S., Hwang, E., Moon, H., Noh, D., & Lee, J. E. (2015) · Nutrients · doi:10.3390/nu7125532 · Cited by 25
“However, we do not have information on the comorbidity status at diagnosis, which has been suggested as a predictor of impaired overall quality of life as well as functional status [42,43], and we could not determine the causal relationship between the ACS guideline and WCRF/AICR recommendation adherence and HRQoL bec…”
Background
Toxicity profile differences of adjuvant docetaxel/cyclophosphamide (TC) between Asian and Caucasian breast cancer patients
Chow, L. W. C., Biganzoli, L., Leo, A. D., Kuroi, K., Han, H. S., Patel, J., Huang, C., Lu, Y., Zhu, L., Chow, C. Y. C., et al. (2017) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.12682 · Cited by 25
A qualitative study of work and early menopause: ‘On-the job’ experiences and career trajectories
Vincent, A. J., Johnston‐Ataata, K., Flore, J., Kokanović, R., Hickey, M., Boyle, J. A., & Teede, H. J. (2024) · Maturitas · doi:10.1016/j.maturitas.2024.107920 · Cited by 24
α‐Ketoglutarate Improves Ovarian Reserve Function in Primary Ovarian Insufficiency by Inhibiting NLRP3‐Mediated Pyroptosis of Granulosa Cells
Liu, K., Wu, Y., Yang, W., Li, T., Wang, Z., Xiao, S., Peng, Z., Li, M., Xiong, W., Li, M., et al. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300784 · Cited by 24
Experiencing menopause in the context of cancer: Women’s constructions of gendered subjectivities
Parton, C., Ussher, J. M., & Perz, J. (2017) · Psychology and Health · doi:10.1080/08870446.2017.1320799 · Cited by 24
Male breast cancer: Medical and psychological management in comparison to female breast cancer. A review
da Silva, T. L. (2016) · Cancer Treatment Communications · doi:10.1016/j.ctrc.2016.03.004 · Cited by 25
“Psychological and functional management and support are key components of treatment for FBC patients [66,67], including for their romantic partners [88,89], and related interventions have been well investigated in these populations [90].”
Influential
Longitudinal effect of emotional processing on psychological symptoms in women under 50 with breast cancer
Martino, M. L., Gargiulo, A., Lemmo, D., Dolce, P., Barberio, D., Abate, V., Avino, F., & Tortoriello, R. (2019) · Health Psychology Open · doi:10.1177/2055102919844501 · Cited by 24
“Although the literature presents women under the age of 50 with breast cancer as a more vulnerable target (Howard-Anderson et al., 2012), showing specific needs (Ruddy et al., 2013) and clinical aspects (Ribnikar et al., 2015), nowadays, only few studies are trying to improve knowledge regarding…”
Background
Breast Cancer in Young Women: Research Priorities. A Report of the Young Survival Coalition Research Think Tank Meeting
Korde, L. A., Partridge, A. H., Esser, M., Lewis, S., Simha, J., & Johnson, R. H. (2015) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2014.0049 · Cited by 23
“60 Future research to clarify these unique concerns should focus on describing long-term psychosocial outcomes, implementing age-appropriate psychosocial screening during and after cancer therapy, and designing and validating interventions to prevent and manage negative psychosocial outcomes.”
Contraceptive utilization and counseling among breast cancer survivors
Mody, S. K., Gorman, J. R., Oakley, L. P., Layton, T. M., Parker, B. A., & Panelli, D. M. (2019) · Journal of Cancer Survivorship · doi:10.1007/s11764-019-00765-x · Cited by 23
Fertility preservation decisions in young women with breast cancer: a qualitative study of health care professionals’ views and experiences
Brown, K., Armstrong, N., & Potdar, N. (2021) · Human Fertility · doi:10.1080/14647273.2021.1933219 · Cited by 23
Family size and duration of fertility in female cancer survivors: a population-based analysis
Anderson, R. A., Kelsey, T., Morrison, D. S., & Wallace, W. H. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.11.011 · Cited by 23
Impact of Chemotherapy-induced Menopause in Women of Childbearing Age With Non-metastatic Breast Cancer – Preliminary Results From the MENOCOR Study
Passildas, J., Collard, O., Savoye, A.-M., Dohou, J., Ginzac, A., Thivat, É., Durando, X., Kwiatkowski, F., Penault-Llorca, F. M., Abrial, C., et al. (2018) · Clinical Breast Cancer · doi:10.1016/j.clbc.2018.10.003 · Cited by 23
What Young Women with Breast Cancer Get Versus What They Want in Online Information and Social Media Supports
Corter, A. L., Speller, B., Sequeira, S., Campbell, C., Facey, M. E., & Baxter, N. N. (2019) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2018.0125 · Cited by 23
The Effectiveness of the Sport “Dragon Boat Racing” in Reducing the Risk of Lymphedema Incidence
Iacorossi, L., Gambalunga, F., Molinaro, S., Domenico, R. D., Giannarelli, D., & Fabi, A. (2018) · Cancer Nursing · doi:10.1097/ncc.0000000000000615 · Cited by 23
“The most common symptoms of depression, related to change in one"s body image, fear of early menopause, infertility, and/or recurrence occur in women who have had breast cancer at a young age.(38) In our study, the women in group A were found to have a higher level of emotional well-being than those in group B, despit…”
Background
Measuring the Multidimensional Reproductive Concerns of Young Adult Male Cancer Survivors
Gorman, J. R., Drizin, J. H., Malcarne, V. L., & Hsieh, T. (2020) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2019.0146 · Cited by 22
Female Oncofertility: Current Understandings, Therapeutic Approaches, Controversies, and Future Perspectives
Vo, K., & Kawamura, K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10235690 · Cited by 22
A remotely delivered, peer-led intervention to improve physical activity and quality of life in younger breast cancer survivors
Weiner, L. S., Nagel, S., Su, H.-C. I., Hurst, S., Levy, S. S., Arredondo, E. M., Hekler, E. B., & Hartman, S. J. (2022) · Journal of Behavioral Medicine · doi:10.1007/s10865-022-00381-8 · Cited by 21
“Key psychosocial concerns include body image disturbances due to physical changes (e.g., hair loss, weight gain, surgical scars), sexual dysfunction, and fatigue (Howard-Anderson et al., 2012; Ruddy et al., 2013).”
Background
Management of menopause in women with breast cancer
Vincent, A. J. (2014) · Climacteric · doi:10.3109/13697137.2014.996749 · Cited by 22
“Menopause/menopausal symptoms, with signifi cant negative effects on quality of life and potential long-term health impacts, may in women with breast cancer be associated with: (1) natural menopause occurring concurrently with a breast cancer diagnosis; (2) recurrence of menopausal symptoms following cessation of horm…”
BackgroundMethodInfluential
Issues of ovarian cancer survivors in the USA: a literature review
Trivers, K. F., Patterson, J. R., Roland, K. B., & Rodriguez, J. L. (2013) · Supportive Care in Cancer · doi:10.1007/s00520-013-1893-5 · Cited by 22
“In one study, 25 % of survivors reported enteringmenopause as a result of treatment and 27% reported distress related to this transition [24], which is lower than similar estimates in young women with breast cancer [36], but the ovarian cancer study included older women (mean age, 56 years) and did not stratify result…”
Result
Breast cancer survivors` recollection of their quality of life: Identifying determinants of recall bias in a longitudinal population-based trial
Lindberg, P., Netter, P., Koller, M. T., Steinger, B., & Klinkhammer‐Schalke, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171519 · Cited by 24
Dynamic changes in quality of life, psychological status, and body image in women who underwent a mastectomy as compared with breast reconstruction: an 8-year follow up
Konara Mudiyanselage, S. P., Wu, Y.-L., Kukreti, S., Chen, C.-C., Lin, C.-N., Tsai, Y.-T., Ku, H.-C., Fang, S.-Y., Wang, J.-D., & Ko, N.-Y. (2023) · Breast Cancer · doi:10.1007/s12282-022-01413-6 · Cited by 22
“Because younger women are very body conscious and long term QoL status to keep their daily lifestyle more friendly than older women [15, 62].”
Background
Coping Among Breast Cancer Survivors: A Confirmatory Factor Analysis of the Brief COPE
Rand, K. L., Cohee, A. A., Monahan, P. O., Wagner, L. I., Shanahan, M. L., & Champion, V. L. (2019) · Journal of Nursing Measurement · doi:10.1891/1061-3749.27.2.259 · Cited by 32

Authors: Howard-Anderson, J., Ganz, P. A., Bower, J. E., & Stanton, A. L.
Affiliations: University of California, Los Angeles (US)
ORCID: Howard-Anderson, J.
Ganz, P. A.
Bower, J. E.
Stanton, A. L.
Venue: JNCI Journal of the National Cancer Institute
Publisher: Oxford University Press (OUP)
Published: 2012-01-23
Volume: 104
Issue: 5
Pages: 386-405
ISSN: 0027-8874 (ISSN-L)
1460-2105
DOI: 10.1093/jnci/djr541
OpenAlex: W2109496096
Cited by: 830
References: 99
Citations by year: 2026: 35 · 2025: 44 · 2024: 38 · 2023: 49 · 2022: 55 · 2021: 69 · 2020: 125 · 2019: 62 · 2018: 75 · 2017: 67 · 2016: 60 · 2015: 51 · 2014: 46 · 2013: 43 · 2012: 10
FWCI: 5.00
Type: journal article
Language: en
Open access: closed
Locations: JNCI Journal of the National Cancer Institute (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Breast Cancer Research Foundation
Jonsson Comprehensive Cancer Center
Topics: Health Sciences › Medicine › Oncology › Cancer survivorship and care
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
Keywords: breast cancer survivors, young women, health-related quality of life, fertility concerns, premature menopause, menopausal symptoms, infertility, depression, anxiety, weight gain, physical inactivity, psychosocial distress, cancer treatment side effects
MeSH terms: Adult, Age Factors, Anxiety, Breast Neoplasms, Depression, Female, Fertility, Humans, Menopause, Premature, Motor Activity, Quality of Life, Risk Factors, Stress, Psychological, United States, Weight Gain, Health Behavior, Exercise, Age Distribution, Survivors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Quality of Life, Fertility Concerns, and Behavioral Health Outcomes in Younger Breast Cancer Survivors: A Systematic Review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks