Cited by 830Cancer survivorship and careChildhood Cancer Survivors' Quality of LifeWomen's cancer prevention and management

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

Quality of Life, Fertility Concerns, and Behavioral Health Outcomes in Younger Breast Cancer Survivors: A Systematic Review

Howard-Anderson, J., Ganz, P. A., Bower, J. E., Stanton, A. L.·2012·JNCI Journal of the National Cancer Institute

DOI 10.1093/jnci/djr541

Open this paper in CoChat — free account

Abstract

BACKGROUND: Breast cancer is the most common cancer in women younger than age 50 years. Cancer treatments in younger women may cause premature menopause, infertility, and negative psychosocial effects. In this systematic review, we examined three key domains of functioning that are particularly relevant for younger breast cancer survivors: health-related quality of life (QOL), menopausal symptoms and fertility concerns, and behavioral health outcomes. METHODS: We conducted a literature review using PubMed and secondary sources and examined 840 articles published between January 1990 and July 2010. Inclusion criteria for articles were 1) published in English after 1989; 2) exclusively analyzed female breast cancer survivors aged 50 years or younger or premenopausal at diagnosis, with baseline characteristics and/or quantitative or descriptive analyses for this age group; 3) investigated QOL (health-related QOL including physical functioning and mental health, depression, and anxiety), menopause- or fertility-related concerns, and weight gain or physical activity-related behavioral health outcomes. Data were extracted using a standardized table collecting the purpose, design, population, and results of each study. Extracted data were reviewed for accuracy by two investigators and presented as descriptive tables. RESULTS: A total of 28 articles met the inclusion criteria (15 cross-sectional studies, eight longitudinal studies, and five randomized trials). Regarding data review, no discordance between investigators was noted. Standardized measures of QOL and depressive symptoms identified worse outcomes as being more frequent or severe in breast cancer survivors aged 50 years or younger when compared with the general age-matched population of women without cancer and to older women (aged >50 years) with breast cancer. Concerns about premature menopause, menopausal symptoms, and infertility were common in younger women (aged ≤ 50 years) and had a role in the level of distress after treatment. Weight gain and physical inactivity were common health outcomes in younger women. CONCLUSIONS: Younger women with breast cancer were found to experience distinct psychosocial and menopause-related concerns, weight gain, and physical inactivity. A need for more longitudinal research, including efforts at intervention to manage these symptoms and adverse health outcomes, remains.

Integrity signals

Registry

Crossref · 10.1093/jnci/djr541

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cancer Statistics, 2010
Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20073 · Cited by 12,596
Untitled work
(1994) · Medical Entomology and Zoology · Cited by 4,156
Effect of Screening and Adjuvant Therapy on Mortality from Breast Cancer
Berry, D. A., Cronin, K. A., Plevritis, S. K., Fryback, D. G., Clarke, L. D., Zelen, M., Mandelblatt, J. S., Yakovlev, A. Y., Habbema, J. D. F., & Feuer, E. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050518 · Cited by 2,456
Center for Epidemiologic Studies Depression Scale (CES-D) as a screening instrument for depression among community-residing older adults.
Lewinsohn, P. M., Seeley, J. R., Roberts, R. E., & Allen, N. B. (1997) · Psychology and Aging · doi:10.1037/0882-7974.12.2.277 · Cited by 1,782
Physical activity and survival after breast cancer diagnosis
Holmes, M. D. (2005) · JAMA · doi:10.1001/jama.293.20.2479 · Cited by 1,772
Future of Cancer Incidence in the United States: Burdens Upon an Aging, Changing Nation
Smith, B. D., Smith, G. L., Hurria, A., Hortobágyi, G. N., & Buchholz, T. A. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.8983 · Cited by 1,733
Life after breast cancer: understanding women's health-related quality of life and sexual functioning.
Ganz, P. A., Rowland, J. H., Desmond, K., Meyerowitz, B. E., & Wyatt, G. E. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.2.501 · Cited by 962
Self-citation
Body image and sexual problems in young women with breast cancer
Fobair, P., STEWART, S. L., Chang, S., D’Onofrio, C. N., Banks, P. J., & Bloom, J. R. (2005) · Psycho-Oncology · doi:10.1002/pon.991 · Cited by 888
Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer
Hershman, D. L., Shao, T., Kushi, L. H., Buono, D., Tsai, W. Y., Fehrenbacher, L., Kwan, M., Gomez, S. L., & Neugut, A. I. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1132-4 · Cited by 870
Early Discontinuation and Nonadherence to Adjuvant Hormonal Therapy in a Cohort of 8,769 Early-Stage Breast Cancer Patients
Hershman, D. L., Kushi, L. H., Shao, T. H., Buono, D. L., Kershenbaum, A., Tsai, W., Fehrenbacher, L., Gomez, S. L., Miles, S. Q., & Neugut, A. I. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.9655 · Cited by 834

Show all 99 references

Research works printed but not linked: 7

1994, JNCI Monographs, 1994, 191
1994, JNCI Monographs, 1994, 1
1999, CANCER RES THER CONTROL, 8, 93
2000, Acta oncol gica, 39, 959
2009, Cancer nursing, 32, 247
2010, 51, 112
Chlebowski, 2002, Journal of Clinical Oncology, 20, 1128, 10.1200/JCO.20.4.1128 · DOI

Sorted by citations

Items 701–800 of 829

PERBEDAAN TINGKAT ANSIETAS DAN DEPRESI ANTARA PASIEN KANKER PAYUDARA DENGAN USIA PENYAKIT KURANG DAN LEBIH DARI SATU TAHUN
Estria, S. R., & Suparti, S. (2018) · Jurnal Keperawatan dan Kesehatan Masyarakat Cendekia Utama · doi:10.31596/jcu.v0i0.217 · Cited by 1
Symptom Clusters in Breast Cancer Survivors Prevalence, Predictors, and Consequences
Ellis, L. M. (2013)
Relationship between Health Literacy and Special Quality of Life and Body Image in Women Undergone Mastectomy in Reproductive Age
Jafari, M., Lamiyan, M., & Hajizadeh, E. (2018) · Health Education and Health Promotion · doi:10.29252/hehp.6.3.109
Impact of a Nutrition and Yoga Intervention in Breast Cancer Suvivors' Quality of Life
Fogarty, T. C. (2018) · doi:10.25148/etd.fidc006869
Psihosocijalni aspekti oboljenja od raka dojke kod mladih žena
Džombić, A. (2019) · Journal of Applied Health Sciences · doi:10.24141/1/5/1/6
EVALUATION OF THE SYSTEMIC AND REGIONAL ANTIBIOTIC THERAPY EFFECTIVENESS AS PART OF COMPLEX THERAPY IN PATIENTS WITH LOCALLY SPREAD BREAST CANCER
Bondar, O. V. (2019) · EUREKA Health Sciences · doi:10.21303/2504-5679.2019.00882
Establishing Insurance Coverage for Iatrogenic Infertility
Reinecke, J. D., Elster, N. R., Letourneau, J. M., & Bowman‐Curci, M. (2019) · Springer eBooks · doi:10.1007/978-3-030-02868-8_27
The Importance of Disclosure for Sexual and Gender Minorities in Oncofertility Cases
Quinn, G. P., Tamargo, C. L., Schabath, M. B., Sampson, A., & Vadaparampil, S. T. (2019) · Springer eBooks · doi:10.1007/978-3-030-02868-8_31
PREDICTING HEALTH-RELATED QUALITY OF LIFE CHANGES AND ENDOCRINE THERAPY UNDER-UTILIZATION IN BREAST CANCER
Pinheiro, L. C. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/cyj6-pt59
Pedicled Flaps for Volume Replacement in Breast Conserving Surgery
Roy, P. G., Rusby, J. E., & Rainsbury, R. (2019) · Springer eBooks · doi:10.1007/978-3-319-62927-8_32
Cancer treatment is associated with a measurable decrease in live births in a large, population-based study
Garg, D., Meeks, H., Johnstone, E. B., Pastuszak, A. W., Berga, S. L., Smith, K. R., Hotaling, J. M., & Letourneau, J. M. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.07.190
Effectiveness of interventions to support male partners of women diagnosed with breast cancer
Kuta, A. (2019) · Cancer Nursing Practice · doi:10.7748/cnp.2019.e1609
Fertility Counseling and Preservation in Breast Cancer
Sella, T., & Partridge, A. H. (2020) · Current Breast Cancer Reports · doi:10.1007/s12609-019-00348-w
Effect of acceptance and commitment-based training on difficulty in emotion regulation and health in women with breast cancer: A clinical trial study
Reskati, M. H., Mirzaian, B., & Hosseini, S. H. (2020) · DOAJ (DOAJ: Directory of Open Access Journals)
Occupational Health Psychology and Women in Asian Contexts
Siu, O. L., Wang, H., & Pagon, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.027
Women and Psychotherapy
Duan, C., & Grazioso, M. D. P. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.044
The Psychology of Women in Entrepreneurship
Chan, E. T., Tang, P. M., & Chen, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.025
Sex, Gender, and Sexuality
Byers, E. S., & Blair, K. L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.005
Understanding Women’s Antisocial and Criminal Behavior
Zhong, H., & Ryder, J. A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.034
Gender and Women’s Sexual and Reproductive Health
Hindin, M. J., & OlaOlorun, F. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.040
Three Ways that Aging Affects Women Differently from Men
Chen, A. X., Tsang, V. H. L., Wong, T. K., Fung, H. H.-L., & Ayalon, L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.012
Work–Family Interface and Crossover Effects
Rajadhyaksha, U. A., & Başkurt, A. B. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.028 · Cited by 1
The Contents and Discontents of the Nature–Nurture Debate
Gangestad, S. W., & Chang, L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.004
Sex Differences on the Brain
Grabowska, A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.006
Women under Pressure
Eagle, G. T., Ayers, S., Mkone, C., & Moroke, M. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.039
Physical Health
Parton, C., Ussher, J. M., Perz, J., & Rubin, L. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.041
Contextualizing the Many Faces of Domestic Violence
Nduna, M., Mkwananzi, S., Wekwete, N. N., & Makongoza, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.030
International and Intersectional Perspectives on the Psychology of Women
Cheung, F. M., & Halpern, D. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.002
Fertility Preservation for Women With Hematologic Malignancies
Loren, A. W. (2020) · The Hematologist · doi:10.1182/hem.v17.2.10285
The Effects of Lifestyle Modifications Including Dietary and Physical Interventions with Cognitive-Behavioral Therapy on Quality of Life and Cancer-Recurrence Rate among Patients with Breast Cancer and Survivors: A Protocol for a Systematic Review and Meta-Analysis of Randomized Controlled Trial
Razmpoosh, E., Mazloom, M., Bassiri, M., Montazeri, A., Sajadian, A. S., Zarrati, M., & Salehi-Abargoueil, A. (2020) · International Journal of Cancer Management · doi:10.5812/ijcm.103647 · Cited by 2
“Promising data have indicated that performing multidisciplinary lifestyle modifications would provide patients with comprehensive long-term management of their disease treatment (15, 16).”
Background
Factors associated with depression and the relationship to quality of life among Saudi women with breast cancer
Al-Shammari, M., & Khalil, A. A. (2020) · Journal of Nursing Education and Practice · doi:10.5430/jnep.v11n4p43
“In studies of women of all ages with breast cancer, younger women typically report responses that indicated a greater likelihood of clinical depression or greater severity of depressive symptoms, a heightened level of stress, and/or worse QoL when compared with older women with breast cancer.[41] Younger women with br…”
Background
Assisted reproductive technologies for fertility preservation and fertility treatment in young women with cancer
Marklund, A. (2020) · Figshare
Cancer Epidemiology Used in Policy Questions
Cook, E. E. (2018) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
The Need for Fertility Preservation in Cancer Patients
Anderson, R. A., & Mitchell, R. T. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108784368.005
Evaluation of the Pathways for Survivors program to address breast cancer survivorship associated distressPreprint
Umashankar, S., Mamounas, M. E., Matthys, M. B., Hadeler, E. K., Wong, E. C., Hicks, G., Hwang, J., Chien, A. J., Rugo, H. S., Hamolsky, D., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-335346/v1
Resection or Preservation? A Tough Surgical Decision for Chinese Breast Cancer Patients Who Are in Line with Breast ConservingPreprint
Zhu, P., Ji, Q., Liu, X., Xu, T., Qi-wei, W., & Wang, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-571616/v1
Imaging the Symptomatic Breast in the Pediatric, Young, Pregnant, Lactating, and Transgender Patient
Shetty, M. K., O’Connell, A. M., Kawakyu-O’Connor, D., & Sharma, N. (2021) · Springer eBooks · doi:10.1007/978-3-030-69476-0_1
Quantifying Burden of Treatment for Breast Cancer Patients from Clinical Encounter Data
Cheng, A. (2016)
Sexual and Reproductive Health Concerns
Shelby, R. A., Coleman, J. N., Arthur, S. S., Acharya, K. S., Heath, A. A., Flather, M. D., Westbrook, K. E., & Dorfman, C. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-75377-1_5
Body Image, Life Satisfaction and Associated Factors Among Swedish Women with Breast Cancer After MastectomyPreprint
Phoosuwan, N., & Lundberg, P. C. (2021) · Research Square · doi:10.21203/rs.3.rs-621488/v1
RELATIONSHIP BETWEEN SELF-ACCEPTANCE AND SELF EFFICACY AMONG LIVER CANCER PAKISTANI FEMALE PATIENTS
Khurshid, M., Ismail, M., Hassan, A., Iqbal, S., & Mirza, S. (2021) · ASEAN Journal of Psychiatry
The Expanded Role of Ovarian Suppression for Young Women’s Breast Cancer: An Era of Patient-Tailored Decision Making
Borges, V. F. (2021) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djab214
Young, single and treated for breast cancer: Making sense of my sexuality - An exploration of women’s stories
Shortt, S. (2014) · ChesterRep (University of Chester)
Evaluation of the Pathways for Survivors Program to Address Breast Cancer Survivorship–Associated Distress: Survey Study
Umashankar, S., Mamounas, M. E., Matthys, M. B., Hadeler, E. K., Wong, E. C., Hicks, G., Hwang, J., Chien, A. J., Rugo, H. S., Hamolsky, D., et al. (2021) · JMIR Cancer · doi:10.2196/31756
“Studies have found increased rates of anxiety and depression among breast cancer survivors over the short and long term, and these problems appear more prominent in younger survivors and those with pre-existing psychological symptoms [4,6,7].”
Background
Epidemiology
Poorvu, P. D., & Partridge, A. H. (2020) · Springer eBooks · doi:10.1007/978-3-030-24762-1_1
Inequality and Social Justice
(2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.031
Work and Family Issues
Clason, C. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.023
Health and Well-Being
(2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.037 · Cited by 1
Developmental Perspectives of the International Psychology of Women
Cheung, F. M., & Halpern, D. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.008
Cognitive and Social Factors
(2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.013
Parting Thoughts
Halpern, D. F., & Cheung, F. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.046
The Underpinnings of Sex and Gender and How to Study Them
Cheung, F. M., & Halpern, D. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.001
Some Final Thoughts and Take-Home Messages
Cheung, F. M., & Halpern, D. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.045
03 / Fertility- and early menopause-related information needs of young breast cancer survivors
Nelen, W. L. D. M., & Sparidaens, E. M. (2018) · doi:10.26226/morressier.5af300b2738ab10027aa986b
Resection or Preservation? A Tough Surgical Decision for Chinese Breast Cancer Patients Who are in Line with Breast ConservingPreprint
Zhu, P., Ji, Q., Liu, X., Xu, T., Wu, Q., & Wang, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-571616/v2
The influence of breast cancer-related lymphedema on women's return-to-work
Sun, Y. (2018) · doi:10.32469/10355/68949
Index
Cheung, F. M., & Halpern, D. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.047
Breast Cancer Patients’ Experience and Wishes Regarding Communication on Sexual Health - The BEROSE StudyPreprint
Aupomerol, M., Chaltiel, D., Pautier, P., Wehrer, D., Véron, L., Degousée, L., Fasse, L., Guéroult-Accolas, L., Meglio, A. D., Scotté, F., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-427074/v2
Surveillance of Patients Following Primary Therapy
Çelik, V., Aydoğan, T., YILMAZ, M. H., Yaşar, N. F., & Müslümanoğlu, M. (2019) · Springer eBooks · doi:10.1007/978-3-030-16792-9_27
Sexualität nach der Therapie gynäkologischer Malignome
Tiechl, J., & Marth, C. (2014) · Springer eBooks · doi:10.1007/978-3-662-45876-1_23
A Qualitative Meta-synthesis of the Post-Traumatic Growth Experiences among Female Breast Cancer Patients and SurvivorsPreprint
He, L., Wu, H., Jean, J. A., Lyu, J., Li, M., Zhang, N., Liu, J., & Zhou, C. (2022) · Research Square · doi:10.21203/rs.3.rs-1965854/v1
Psychological stress and quality of life among Indian patients after breast cancer surgery
Roy, D. K. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns8.13324
“Additionally, early identification as well as treatment of BC have saved the lives of numerous individuals (Howard-Anderson et al., 2012).”
Background
Amenorrhea in Oncological Patients
Caretto, M., & Simoncini, T. (2023) · ISGE series · doi:10.1007/978-3-031-22378-5_10
Quality of Life and Patient Reported Outcomes in Breast Cancer
Borsky, K. L., & Tsang-Wright, F. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-27597-5_11
Preservation of fertility in young patients with breast cancer, including BRCA1, BRCA2 mutation carriers
Zimovjanová, M. (2023) · Onkologie · doi:10.36290/xon.2023.033
Effects of Healthy Nutrition Barriers on the Quality of Life, Body Composition, and Depression Status of Breast Cancer Patients
Baş, D., & BİÇER, N. Ç. (2023) · Journal of Oncological Sciences · doi:10.37047/jos.2023-97828
Breast Cancer
Agostinetto, E., Gombos, A., & Piccart, M. J. (2023) · Springer eBooks · doi:10.1007/978-3-030-93702-7_2-1
Quality of Life in Locally Advanced Carcinoma Rectum Patients During Various Phases of NACRT: An Indian Perspective
Hans, R., Sharma, N., Tiwari, M., Dwivedi, S. K., & Dwivedi, S. (2024) · Indian Journal of Surgical Oncology · doi:10.1007/s13193-024-01878-1
“This explains to some extent, the larger clinically meaningful changes in the social functioning and anxiety subscales in our study [20].”
Breast Cancer
Rottmann, N., Ewertz, M., & Hansen, D. G. (2023) · Springer eBooks · doi:10.1007/978-3-031-17299-1_3864
BR-I
Maggino, F. (2023) · Springer eBooks · doi:10.1007/978-3-031-17299-1_300362
HEALTH-RELATED QUALITY OF LIFE IN POSTMENOPAUSAL WOMEN WITH ADVANCED BREAST CANCER RECEIVING ADJUVANT HORMONE THERAPY (RIBOCICLIB AND LETROZOLE)
Rohman, S., Anwarudin, W., Azizah, N., Mauludin, M. N. I., & Sya’bany, A. K. (2024) · Medical Sains Jurnal Ilmiah Kefarmasian · doi:10.37874/ms.v9i2.1092
“The results of this study are also in line with the MONALEESA-2 study, which showed that patients who received ribociclib plus letrozole lived longer without exacerbating cancer (development-free survival) than patients treated with letrozole alone (Howard-Anderson et al., 2012).”
Result
Unique Issues in Oncological Patients: From Amenorrhea to Fertility Preservation
Caretto, M., Benvenuti, M., & Simoncini, T. (2024) · ISGE series · doi:10.1007/978-3-031-55300-4_12
The Good Quality of Life of Breast Carcinoma with Aggressive Metastasis to Multilevel Vertebrae: A Case Report
Mannagalli, Y., Kirana, I. R., Niatazya, A., Utami, L. W., & Pratiwi, D. R. (2024) · Indonesian Journal of Cancer · doi:10.33371/ijoc.v18i2.1148
“It is evident that QoL in breast cancer patients can vary at different disease stages, as well as after diagnosis, before treatment, after treatment, and long-term effects from the therapy and the cancer itself [26].”
Background
Acupuncture and its potential in enhancing mental well-being for breast cancer survivors: An evidence-based insight
Cruz, G., Fonseca, M., da Silva, R., Torres, R., & Rodrigues, J. M. (2024) · Revista Internacional de Acupuntura · doi:10.1016/j.acu.2024.100297
Uptake of gonadotrophin‐releasing hormone agonists for prevention of premature ovarian insufficiency in women undergoing chemotherapy: an Australian single‐centre study
Martin, F. C., Phillips, K., Lee, N., Paul, D., Price, S., Rozen, G., Stern, C., Xie, J., & Cui, W. (2024) · Internal Medicine Journal · doi:10.1111/imj.16564
Fertoprotective agents and tumor response: a narrative review
Alley, A. W., Constance, J. E., & Letourneau, J. M. (2025) · F&S Reviews · doi:10.1016/j.xfnr.2025.100087
The Role of Perceived Social Support on the Mental Health of Patients with Oral Squa-mous Cell Carcinoma in Shiraz City in 2022-23
Mirzaei, K., Jahromi, A. Z., & Mirzaei, I. (2025) · Bulletin de la Banque Méllié Iran. · doi:10.61186/ismj.27.4.284
Sleeping Spermatozoa: The Symbolism of Gamete Cryopreservation in the Context of Cancer in AYAs
Koscinski, I., Mazzoléni, C., Verhaeghe, F., Klein, J.-P., & Ravel, C. (2025) · Life · doi:10.3390/life15050685
Nutritional status and quality of life of patients with breast cancer receiving chemotherapy
Nguyen, T. Q., Pham, P., Hoang, B., Tran, T. T. B., & Le, H. T. (2025) · World Academy of Sciences Journal · doi:10.3892/wasj.2025.364
Factors affecting daily activities in premenopausal breast cancer patients undergoing endocrine therapy
Mikan, F., Mami, F. B., & Hiroko, K. (2025) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2025.102928
Mapping the Unmet Informational Needs of Young Portuguese Female Cancer Survivors: Psychometric Validation of a Multidimensional Scale
Almeida, L., Bártolo, A., Monteiro, S. O. M., Silva, I. S., Conde, A., Araújo, A. M., Lourenço, L., & Santos, I. M. (2025) · Healthcare · doi:10.3390/healthcare13141757
“Agents such as cyclophosphamide, procarbazine, and busulfan are especially harmful, with the potential to cause permanent ovarian failure, infertility, and early menopause [10,11].”
Premature ovarian insufficiency: An update. A literature review
Abdelhafez, M. M., Ahmed, K. A. M., Ahmed, N. A. M., Ismail, M. H., Daud, M. N., Eldiasty, A., Amri, M. F., Jeffree, M. S., Kadir, F., Baharuddin, D. M. P., et al. (2025) · Clínica e Investigación en Ginecología y Obstetricia · doi:10.1016/j.gine.2025.101071
The paradigm shift, the definition of pregnancy-associated breast cancer is outdated
Ульрих, Д. Г., Криворотько, П. В., Жильцова, Е. К., Bondarchuk, Y. I., Chekina, Y. A., Khalturin, V. J., Kalinina, E. A., Кудайбергенова, А. Г., Semiglazova, Т. Y., Ульрих, Е. А., et al. (2025) · Siberian Journal of Oncology · doi:10.21294/1814-4861-2025-24-5-5-16
Investigating the mental health burden amongst breast and cervical cancer patients in Rwanda using a modified self-reported questionnaire for mental health screening (SRQ-20): A validation study
Rusatira, J. C., Uwimana, J. B., Rutagumba, D., Byiringiro, S., Natta, S., Espmark, J., Rurangwa, E., Kågesten, A., Nzeyimana, I., & Ndoli, D. A. (2025) · BMC Women s Health · doi:10.1186/s12905-025-04207-y
“Several theories have been suggested to explain these findings and among the possible key factors associated with poor mental health are sexual and reproductive health concerns, in particular fertility[25].”
Additional file 8 of Mutational landscape differences between young-onset and older-onset breast cancer patients
Mealey, N. E., O’Sullivan, D. E., Pader, J., Ruan, Y., Wang, E., Quan, M. L., & Brenner, D. R. (2020) · Figshare · doi:10.6084/m9.figshare.11979549
Additional file 1 of Health-related quality of life in breast cancer patients: review of reviews from 2008 to 2018
Mokhatri-Hesari, P., & Montazeri, A. (2020) · Figshare · doi:10.6084/m9.figshare.13083326
Additional file 2 of Exploration of fertility and early menopause related information needs and development of online information for young breast cancer survivors
Sparidaens, E. M., Beerendonk, C. C. M., Fleischer, K., Nelen, W. L. D. M., Braat, D. D. M., & Hermens, R. P. M. G. (2022) · Figshare · doi:10.6084/m9.figshare.20430389
Additional file 4 of Mutational landscape differences between young-onset and older-onset breast cancer patients
Mealey, N. E., O’Sullivan, D. E., Pader, J., Ruan, Y., Wang, E., Quan, M. L., & Brenner, D. R. (2020) · Figshare · doi:10.6084/m9.figshare.11979528
Additional file 1 of Exploration of fertility and early menopause related information needs and development of online information for young breast cancer survivors
Sparidaens, E. M., Beerendonk, C. C. M., Fleischer, K., Nelen, W. L. D. M., Braat, D. D. M., & Hermens, R. P. M. G. (2022) · Figshare · doi:10.6084/m9.figshare.20430386
Additional file 3 of Mutational landscape differences between young-onset and older-onset breast cancer patients
Mealey, N. E., O’Sullivan, D. E., Pader, J., Ruan, Y., Wang, E., Quan, M. L., & Brenner, D. R. (2020) · Figshare · doi:10.6084/m9.figshare.11979522
Additional file 2 of Mutational landscape differences between young-onset and older-onset breast cancer patients
Mealey, N. E., O’Sullivan, D. E., Pader, J., Ruan, Y., Wang, E., Quan, M. L., & Brenner, D. R. (2020) · Figshare · doi:10.6084/m9.figshare.11979519
Additional file 1 of Mutational landscape differences between young-onset and older-onset breast cancer patients
Mealey, N. E., O’Sullivan, D. E., Pader, J., Ruan, Y., Wang, E., Quan, M. L., & Brenner, D. R. (2020) · Figshare · doi:10.6084/m9.figshare.11979516
Additional file 7 of Mutational landscape differences between young-onset and older-onset breast cancer patients
Mealey, N. E., O’Sullivan, D. E., Pader, J., Ruan, Y., Wang, E., Quan, M. L., & Brenner, D. R. (2020) · Figshare · doi:10.6084/m9.figshare.11979543
Zip Code Overdiagnosis: Disparities in Fertility Preservation for Young Patients
Safrai, M., Zielen, A. C., Neelley, R. E., Wasser, L. M., Chu, T., & Orwig, K. E. (2025) · Women s Health Reports · doi:10.1177/26884844251391281
“71,72 Therefore, OTC should be accessible to all patients regardless of socioeconomic status.”
Integrating Exercise into Oncologic Care for Young Patients with Breast Cancer: Evidence from the ONCOMOVE Trials
Leão, I. A. T., Antunes, P., Garcia, C., Esteves, D., Alves, A. J., Viamonte, S., & Joaquim, A. (2025) · Journal of young women's breast cancer and health. · doi:10.4103/ywbc.ywbc_12_25
Effects of Manual Lymphatic Drainage Intervention Combined with Hold-Relax Technique on Lymphedema and Arm Function in Patients with Breast Cancer: A Preliminary Study
Jung, J.-C., Yang, K.-H., & Park, D.-J. (2025) · PNF and Movement · doi:10.21598/jkpnfa.2025.23.3.471
Impact of a Reproductive Health Survivorship Care Plan on Fertility, Pregnancy Concerns, and Accessing Reproductive Healthcare Among Young Nulliparous Breast Cancer Survivors
Shliakhtsitsava, K., Stark, S. S., Prasad, T., Boles, S., Chingos, D. T., Ehren, J. L., Gorman, J. R., Romero, S. A. D., Mao, J. J. J., Nathan, P. C., et al. (2026) · Cancer Reports · doi:10.1002/cnr2.70433
Impact of breast cancer on patients’ personal, social, and psychological aspects: the quality of life, mental health, and social support of breast cancer patients
Irshad, M., Varghese, A. L., & Al-Ozairi, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33347-7.00008-7 · Cited by 1
Relationships between social support and resilience of breast cancer patients in Indonesia: A cross-sectional study
Pulungan, R. M., Helda, H., Wahyono, T. Y. M., & Sutandyo, N. (2026) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_250_25
“[16,18] Other study results showed a relationship between women’s education level and knowledge of breast cancer risk factors.”
Diet and nutrition considerations in integrative oncology
Price, L., Dearden, J., & Greenlee, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30194-0.00039-4

Authors: Howard-Anderson, J., Ganz, P. A., Bower, J. E., & Stanton, A. L.
Affiliations: University of California, Los Angeles (US)
ORCID: Howard-Anderson, J.
Ganz, P. A.
Bower, J. E.
Stanton, A. L.
Venue: JNCI Journal of the National Cancer Institute
Publisher: Oxford University Press (OUP)
Published: 2012-01-23
Volume: 104
Issue: 5
Pages: 386-405
ISSN: 0027-8874 (ISSN-L)
1460-2105
DOI: 10.1093/jnci/djr541
OpenAlex: W2109496096
Cited by: 830
References: 99
Citations by year: 2026: 35 · 2025: 44 · 2024: 38 · 2023: 49 · 2022: 55 · 2021: 69 · 2020: 125 · 2019: 62 · 2018: 75 · 2017: 67 · 2016: 60 · 2015: 51 · 2014: 46 · 2013: 43 · 2012: 10
FWCI: 5.00
Type: journal article
Language: en
Open access: closed
Locations: JNCI Journal of the National Cancer Institute (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Breast Cancer Research Foundation
Jonsson Comprehensive Cancer Center
Topics: Health Sciences › Medicine › Oncology › Cancer survivorship and care
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
Keywords: breast cancer survivors, young women, health-related quality of life, fertility concerns, premature menopause, menopausal symptoms, infertility, depression, anxiety, weight gain, physical inactivity, psychosocial distress, cancer treatment side effects
MeSH terms: Adult, Age Factors, Anxiety, Breast Neoplasms, Depression, Female, Fertility, Humans, Menopause, Premature, Motor Activity, Quality of Life, Risk Factors, Stress, Psychological, United States, Weight Gain, Health Behavior, Exercise, Age Distribution, Survivors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Quality of Life, Fertility Concerns, and Behavioral Health Outcomes in Younger Breast Cancer Survivors: A Systematic Review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks