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Prevalence of Depression in Patients With Cancer
Open accessAbstract
Depression is the psychiatric syndrome that has received the most attention in individuals with cancer. The study of depression has been a challenge because symptoms occur on a broad spectrum that ranges from sadness to major affective disorder and because mood change is often difficult to evaluate when a patient is confronted by repeated threats to life, is receiving cancer treatments, is fatigued, or is experiencing pain. Although many research groups have assessed depression in cancer patients since the 1960s, the reported prevalence (major depression, 0%-38%; depression spectrum syndromes, 0%-58%) varies significantly because of varying conceptualizations of depression, different criteria used to define depression, differences in methodological approaches to the measurement of depression, and different populations studied. Depression is highly associated with oropharyngeal (22%-57%), pancreatic (33%-50%), breast (1.5%-46%), and lung (11%-44%) cancers. A less high prevalence of depression is reported in patients with other cancers, such as colon (13%-25%), gynecological (12%-23%), and lymphoma (8%-19%). This report reviews the prevalence of depression in cancer patients throughout the course of cancer.
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“Some studies have found that head and neck cancer is associated with the highest documented rates of depression and anxiety compared with other cancer types [5].”
From Acceptance and commitment therapy versus mindfulness-based stress reduction for newly diagnosed head and neck cancer patients: A randomized controlled trial assessing efficacy for positive psychology, depression, anxiety, and quality of life (2022) · cites this paper as [5]
Experimental — accuracy not yet measuredIn the citing paper
“For example, cancer patients exhibit elevated circulating proinflammatory cytokines and develop depression and fatigue at rates approaching 50% (Musselman et al., 2001b, Massie, 2004, Jehn et al., 2006).”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Massie, 2004
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Metadata
- Authors
- Massie, M. J.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Massie, M. J.
- Venue
- Journal of the National Cancer Institute Monographs
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07-01
- Volume
- 2004
- Issue
- 32
- Pages
- 57-71
- ISSN
- 1052-6773 (ISSN-L)
- OpenAlex
- W2111457041
- Cited by
- 1,408
- References
- 117
- Citations by year
- 2026: 34 · 2025: 33 · 2024: 35 · 2023: 62 · 2022: 102 · 2021: 74 · 2020: 65 · 2019: 79 · 2018: 62 · 2017: 63 · 2016: 82 · 2015: 76 · 2014: 81 · 2013: 119 · 2012: 104
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JNCI Monographs (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- depression, cancer patients, prevalence, major depressive disorder, oropharyngeal cancer, pancreatic cancer, breast cancer, lung cancer, cancer-related depression, mood assessment
- MeSH terms
- Depressive Disorder, Fatigue, Humans, Neoplasms, Pain, Risk Factors, Sex Factors, Prevalence
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