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Cited by 704

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

The hypersensitive response; the centenary is upon us but how much do we know?

Open access
Mur, Luis A. J., Kenton, Paul, Lloyd, Amanda J., Ougham, Helen, Prats, Elena·2008·Journal of Experimental Botany

Abstract

With the centenary of the first descriptions of 'hypersensitiveness' following pathogenic challenge upon us, it is appropriate to assess our current understanding of the hypersensitive response (HR) form of cell death. In recent decades our understanding of the initiation, associated signalling, and some important proteolytic events linked to the HR has dramatically increased. Genetic approaches are increasingly elucidating the function of the HR initiating resistance genes and there have been extensive analyses of death-associated signals, calcium, reactive oxygen species (ROS), nitric oxide, salicylic acid, and now sphingolipids. At the same time, attempts to draw parallels between mammalian apoptosis and the HR have been largely unsuccessful and it may be better to consider the HR to be a distinctive form of plant cell death. We will consider if the HR form of cell death may occur through metabolic dysfunction in which malfunctioning organelles may play a major role. This review will highlight that although our knowledge of parts of the HR is excellent, a comprehensive molecular model is still to be attained.

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Metadata

Authors
Mur, L. A. J., Kenton, P., Lloyd, A. J., Ougham, H., & Prats, E.
Venue
Journal of Experimental Botany
Published
2007-12-12
Volume
59
Issue
3
Pages
501-520
ISSN
  • 0022-0957 (ISSN-L)
  • 1460-2431
OpenAlex
W2140302681
Cited by
704
References
6
FWCI
36.58
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The hypersensitive response; the centenary is upon us but how much do we know? https://app.cochat.ai/papers/10.1093/jxb/erm239
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Mur, L. A. J., Kenton, P., Lloyd, A. J., Ougham, H., & Prats, E. (2008). The hypersensitive response; the centenary is upon us but how much do we know? Journal of Experimental Botany. https://doi.org/10.1093/jxb/erm239

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