Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants

Cordoba, E.; Salmi, M.; Leon, P.

doi:10.1093/jxb/erp190

Cited by 346Plant biochemistry and biosynthesisPlant Gene Expression AnalysisPlant Molecular Biology Research

Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants

Cordoba, E., Salmi, M., Leon, P.·2009·Journal of Experimental Botany

DOI 10.1093/jxb/erp190

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Abstract

The methyl-D-erythritol 4-phosphate pathway is responsible for the biosynthesis of a substantial number of natural compounds of biological and biotechnological importance. In recent years, this pathway has become an obvious target to develop new herbicides and antimicrobial drugs. In addition, the production of a variety of compounds of medical and agricultural interest may be possible through the genetic manipulation of this pathway. To this end, a complete understanding of the molecular mechanisms that regulate this pathway is of tremendous importance. Recent data have accumulated that show some of the multiple mechanisms that regulate the methyl-D-erythritol 4-phosphate pathway in plants. In this review we will describe some of these and discuss their implications. It has been demonstrated that 1-deoxy-D-xylulose-5-phosphate synthase (DXS), the first enzyme of this route, plays a major role in the overall regulation of the pathway. A small gene family codes for this enzyme in most of the plants which have been analysed so far, and the members of these gene families belong to different phylogenetic groups. Each of these genes exhibits a distinct expression pattern, suggesting unique functions. One of the most interesting regulatory mechanisms recently described for this pathway is the post-transcriptional regulation of the level of DXS and DXR proteins. In the case of DXS, this regulation appears conserved among plants, supporting its importance. The evidence accumulated suggests that this regulation might link the activity of this pathway with the plant's physiological conditions and the metabolic demand for the final products of this route.

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DXR and HDR may have rate-limiting roles for the production of IDP and DMADP.
“DXR and HDR may also have rate-limiting roles for the production of IDP and DMADP [33].”
From Relative expression of genes of terpene metabolism in different tissues of Artemisia annuaL (2011) · cites this paper as [33]
DXS plays a major role in the overall regulation of the MEP pathway.
“It is well established that DXS, the first enzyme of the MEP pathway, plays a major role in the overall regulation of the pathway [33].”
From Relative expression of genes of terpene metabolism in different tissues of Artemisia annuaL (2011) · cites this paper as [33]

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Authors: Cordoba, E., Salmi, M., & Leon, P.
Affiliations: Universidad Nacional Autónoma de México (MX)
ORCID: Salmi, M.
Venue: Journal of Experimental Botany
Publisher: Oxford University Press (OUP)
Published: 2009-07-01
Volume: 60
Issue: 10
Pages: 2933-2943
ISSN: 0022-0957 (ISSN-L)
1460-2431
DOI: 10.1093/jxb/erp190
OpenAlex: W2136221868
Cited by: 346
References: 69
Citations by year: 2026: 16 · 2025: 15 · 2024: 20 · 2023: 23 · 2022: 28 · 2021: 18 · 2020: 12 · 2019: 30 · 2018: 23 · 2017: 23 · 2016: 14 · 2015: 28 · 2014: 19 · 2013: 23 · 2012: 21
FWCI: 1.38
Type: journal article
Language: en
Open access: closed
Locations: Journal of Experimental Botany (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Gene Expression Analysis
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: 1-deoxy-D-xylulose 5-phosphate synthase, doxorubicin, post-transcriptional regulation, gene expression patterns, phylogenetic groups, herbicide targets, antimicrobial drug targets
MeSH terms: Erythritol, Plant Proteins, Plants, Sugar Phosphates, Gene Expression Regulation, Plant, Metabolic Networks and Pathways

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Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants

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