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Trace metal metabolism in plants
Open accessAbstract
Many trace metals are essential micronutrients, but also potent toxins. Due to natural and anthropogenic causes, vastly different trace metal concentrations occur in various habitats, ranging from deficient to toxic levels. Therefore, one focus of plant research is on the response to trace metals in terms of uptake, transport, sequestration, speciation, physiological use, deficiency, toxicity, and detoxification. In this review, we cover most of these aspects for the essential micronutrients copper, iron, manganese, molybdenum, nickel, and zinc to provide a broader overview than found in other recent reviews, to cross-link aspects of knowledge in this very active research field that are often seen in a separated way. For example, individual processes of metal usage, deficiency, or toxicity often were not mechanistically interconnected. Therefore, this review also aims to stimulate the communication of researchers following different approaches, such as gene expression analysis, biochemistry, or biophysics of metalloproteins. Furthermore, we highlight recent insights, emphasizing data obtained under physiologically and environmentally relevant conditions.
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“Moreover, metal ion transport into vacuoles occurs through CDF (cation diffusion facilitator), MTP (metal tolerance protein), and P1B type ATPase HMA3 (Krämer et al., 2007; Verbruggen et al., 2009b; Andresen et al., 2018).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Andresen et al., 2018
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“A great deal of metal ion transport has been explored through studies on ZIP transporters, as they are involved mainly in the uptake of metal ions (Krämer et al., 2007; Andresen et al., 2018).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Andresen et al., 2018
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“The mechanisms of micronutrient distribution to the edible organs are still only partially understood (Andresen et al., 2018).”
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“…of Mn2þ are distributed amongst different compartments, such as reactive O2 scavenging in the mitochondria by Mn2þ-Superoxide Dismutase (SOD), phytohormone deconjugation in the endoplasmic reticulum (ER), and glycosylation in the Golgi apparatus (Andresen et al., 2018; Alejandro et al., 2020).”
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“Zinc is taken up from the soil solution as Zn2+ or complexed with organic ligands.”
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“A great deal of metal ion transport has been explored through studies on ZIP transporters, as they are involved mainly in the uptake of metal ions (Krämer et al., 2007; Andresen et al., 2018).”
A review on the public health implications of heavy metals
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“The more demanding direct hydrolysis of urea and guanidine could explain why urease and guanidine hydrolase are both dependent on the scarcely available Ni 2+ that also has a low threshold for toxicity 38 .”
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BackgroundNicotianamine: A Key Player in Metal Homeostasis and Hyperaccumulation in Plants
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“7) and absorb Fe2+ through the roots, for example, via nonselective iron-regulated transporter 1 (IRT1), belonging to the ZIP (ZRT/IRT-like proteins) family [30,37,54,55].”
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BackgroundSeed nutripriming with zinc is an apt tool to alleviate malnutrition
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“It is also present in transcription factors such as zinc finger family of transcription factors, thus having a role in gene expression (Andresen et al., 2018; M. Veena J. T. Puthur (&) Plant Physiology and Biochemistry Division, Department of Botany, University of Calicut, C. U. Campus P.”
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“Additionally, endocytosis and exocytosis may be involved in metal uptake and export from the cytoplasm (Andresen et al., 2018).”
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“amounts by the plant (Marschner, 2012), they act as metal components or regulatory cofactors in a large number of enzymes involved in photosynthesis and antioxidative metabolism (van van Oijen et al., 2004; Hänsch & Mendel, 2009; da da Silva et al., 2011; Dalcorso et al., 2014; Andresen et al., 2018), which may explai…”
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“It acts as an enzyme cofactor or a catalytic metal (Andresen et al., 2018).”
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Tan, Y., Sun, L., Song, Q., Mao, D., Zhou, J., Jiang, Y., Wang, J., Fan, T., Zhu, Q., Huang, D., et al. (2019) · Theoretical and Applied Genetics · doi:10.1007/s00122-019-03485-z · Cited by 45
“Several genes involved in trace mineral accumulation in rice grain have been identified through functional genomics (Andresen et al. 2018; Bashir et al. 2016; Huang and Salt 2016).”
BackgroundAnalysis of trace metal distribution in plants with lab-based microscopic X-ray fluorescence imaging
Mijovilovich, A., Morina, F., Bokhari, S. N. H., Wolff, T., & Küpper, H. (2020) · Plant Methods · doi:10.1186/s13007-020-00621-5 · Cited by 45
Self-citationUptake and transport mechanisms of rare earth hyperaccumulators: A review
Wang, H., Chen, Z., Feng, L., Chen, Z., Owens, G., & Chen, Z. (2024) · Journal of Environmental Management · doi:10.1016/j.jenvman.2023.119998 · Cited by 44
Pandey, A., Srivastava, S., & Kumar, S. (2019) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2019.105319 · Cited by 43
Metal nutrition and transport in the process of symbiotic nitrogen fixation
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“As a cofactor in numerous enzymatic reactions, copper is involved in electron transfer in photosynthesis, respiration, carbohydrate allocation, ethylene signaling, and regulation of free radical levels (Emamverdian et al., 2015; Andresen et al., 2018).”
BackgroundNutrient-dependent regulation of symbiotic nitrogen fixation in legumes
Ma, Y., Xiao, C., Liu, J., & Ren, G. (2024) · Horticulture Research · doi:10.1093/hr/uhae321 · Cited by 42
“Copper (Cu) is critical for electron transfer in photosynthesis, respiration, and carbohydrate metabolism, as well as regulating free radicals through Cu–Zn superoxide dismutase [3, 170].”
Moustakas, M., Bayçu, G., Gevrek, N., Moustaka, J., Csatári, I., & Rognes, S. E. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-04126-0 · Cited by 42
“Thus, although Zn2+ is a redox-inert element, it produces reactive oxygen species (Keunen et al. 2011; Andresen et al. 2018).”
BackgroundIon-uptake mechanisms of individual cells and roots: short-distance transport
Coskun, D., & White, P. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-819773-8.00018-6 · Cited by 42
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“Histidine is involved in the translocation mechanisms in both non-hyperaccumulating and hyperaccumulating plants (see reviews by Leitenmaier and Küpper, 2013; Andresen et al. , 2018).”
Self-citationOsIRO3 Plays an Essential Role in Iron Deficiency Responses and Regulates Iron Homeostasis in Rice
Wang, W., Ye, J., Ma, Y., Wang, T., Shou, H., & Zheng, L. (2020) · Plants · doi:10.3390/plants9091095 · Cited by 41
“Fe deficiency can induce some classical responses in plants, including chlorosis of new leaves, inhibition of growth development, and upregulation of Fe homeostasis genes [3,36,37].”
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Nechita, C., Iordache, A. M., Lemr, K., Levanič, T., & Pluháček, T. (2021) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2021.128428 · Cited by 41
Plant Copper Metalloenzymes As Prospects for New Metabolism Involving Aromatic Compounds
Mydy, L. S., Chigumba, D. N., & Kersten, R. D. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.692108 · Cited by 59
“, 2018), although definitive evidence for copper as a cofactor was not discovered until 1961 in pea seedlings (Pisum sativum) (Mann, 1961; Andresen et al., 2018).”
BackgroundForging a symbiosis: transition metal delivery in symbiotic nitrogen fixation
González‐Guerrero, M., Navarro‐Gómez, C., Rosa‐Núñez, E., Echávarri‐Erasun, C., Imperial, J., & Escudero, V. (2023) · New Phytologist · doi:10.1111/nph.19098 · Cited by 40
“Plants have developed precise and exquisitely controlled mechanisms for soil metal uptake and delivery/distribution within the plant (Mendel, 2011; Olsen & Palmgren, 2014; Connorton et al ., 2017; Andresen et al ., 2018).”
BackgroundZeng, J., Han, G., Zhang, S., Zhang, Q., & Qu, R. (2023) · Atmospheric Environment · doi:10.1016/j.atmosenv.2023.120242 · Cited by 38
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Long-distance transport in the xylem and phloem
White, P. J., & Ding, G. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-819773-8.00002-2 · Cited by 37
“Wild barley serves as a source for biofortification of barley grains”
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Plant Recovery after Metal Stress—A Review
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Choudhury, S. R., Moulick, D., Mazumder, M. K., Pattnaik, B. K., Ghosh, D., Vemireddy, L. R., Aldhahrani, A., Soliman, M. M., Gaber, A., & Hossain, A. (2022) · Antioxidants · doi:10.3390/antiox11081500 · Cited by 36
The stimulatory effect and mechanism of low-dose lanthanum on soybean leaf cells
Ben, Y., Cheng, M., Liu, Y., Wang, L., Yang, Q., Huang, X., & Zhou, Q. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129924 · Cited by 36
Gu, D., Zhou, X., Ma, Y., Xu, E., Yu, Y., Liu, Y., Chen, X., & Zhang, W. (2020) · Plant Science · doi:10.1016/j.plantsci.2020.110754 · Cited by 35
Steliga, T., & Kluk, D. (2021) · Toxics · doi:10.3390/toxics9070148 · Cited by 35
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“sclarea plants against heavy metal stress, as Fe is an essential trace element required for respiration and photosynthesis, as well as for many fundamental biological redox reactions [50,55].”
BackgroundInfluentialDesert dust deposition supplies essential bioelements to Red Sea corals
Blanckaert, A. C. A., Omanović, D., Fine, M., Grover, R., & Ferrier‐Pagès, C. (2022) · Global Change Biology · doi:10.1111/gcb.16074 · Cited by 36
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“Trace metals are essential components of electron transport chains or important cofactors for enzymes involved in various biological processes, such as chlorophyll synthesis, nitrate reduction, and photoprotection or photorepair (Twining and Baines, 2013; Andresen et al., 2018).”
BackgroundA profound explanation of why eating green (wild) edible plants promote health and longevity
Åhlberg, M. (2021) · Food Frontiers · doi:10.1002/fft2.106 · Cited by 32
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Zinc deficiency responses: bridging the gap between Arabidopsis and dicotyledonous crops
Thiébaut, N., & Hanikenne, M. (2021) · Journal of Experimental Botany · doi:10.1093/jxb/erab491 · Cited by 31
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“Previous studies have reported that alkaline or calcareous soil contained low Mn content, while acidic and flooded soil contained high Mn content (Wei Yang et al. 2008; Schmidt et al. 2016; Andresen et al. 2018; Alejandro et al. 2020).”
BackgroundInfluential
Metadata
- Authors
- Andresen, E., Peiter, E., & Küpper, H.
- Affiliations
- Czech Academy of Sciences (CZ)
- Martin Luther University Halle-Wittenberg (DE)
- Corresponding author
- Küpper, Hendrik
- Venue
- Journal of Experimental Botany
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-02-13
- Volume
- 69
- Issue
- 5
- Pages
- 909-954
- ISSN
- 0022-0957 (ISSN-L)
- 1460-2431
- OpenAlex
- W2791034768
- Cited by
- 431
- References
- 611
- Citations by year
- 2026: 30 · 2025: 49 · 2024: 58 · 2023: 65 · 2022: 70 · 2021: 87 · 2020: 34 · 2019: 26 · 2018: 11
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Experimental Botany (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education of the Czech Republic (CZ.02.1.01/0.0/0.0/15_003/0000336)
- Czech Academy of Sciences (60077344)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Physical Sciences › Chemistry › Analytical Chemistry › Heavy Metals in Plants
- Keywords
- trace metal metabolism, micronutrients, metal uptake, metal transport, metal sequestration, metal speciation, metal deficiency, metal toxicity, detoxification, copper, iron, manganese, molybdenum, nickel, zinc, metalloproteins, plant metal homeostasis
- MeSH terms
- Metals, Plants, Trace Elements
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