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Cited by 27Single-cell and spatial transcriptomicsCancer Genomics and DiagnosticsBioinformatics and Genomic Networks

Spatiotemporal Omics-Refining the landscape of precision medicine

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Zhang, Jiajun, Yin, Jianhua, Heng, Yang, Xie, Ken, Chen, Ao, Amit, Ido, Bian, Xiu-wu, Xu, Xun·2022·Life Medicine
DOI 10.1093/lifemedi/lnac053PMC PMC11749813
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Abstract

Current streamline of precision medicine uses histomorphological and molecular information to indicate individual phenotypes and genotypes to achieve optimal outcome of treatment. The knowledge of detected mutations and alteration can hardly describe molecular interaction and biological process which can finally be manifested as a disease. With molecular diagnosis revising the modalities of disease, there is a trend in precision medicine to apply multiomic and multidimensional information to decode tumors, regarding heterogeneity, pathogenesis, prognosis, etc. Emerging state-of-art spatiotemporal omics provides a novel vision for in discovering clinicopathogenesis associated findings, some of which show a promising potential to be translated to facilitate clinical practice. Here, we summarize the available spatiotemporal omic technologies and algorithms, highlight the novel scientific findings and explore potential applications in the clinical scenario. Spatiotemporal omics present the ability to provide impetus to rewrite clinical pathology and to answer outstanding clinical questions. This review emphasizes the novel vision of spatiotemporal omics to refine the landscape of precision medicine in the clinic.

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Cited by

Sorted by citations

Authors
Zhang, J., Yin, J., Heng, Y., Xie, K., Chen, A., Amit, I., Bian, X.-W., & Xu, X.
Affiliations
  • BGI Group (China) (CN)
  • Weizmann Institute of Science (IL)
  • University of Science and Technology of China (CN)
Corresponding author
  • Amit, Ido
  • Bian, Xiu-wu
  • Xu, Xun
ORCID
Venue
Life Medicine
Publisher
Oxford University Press (OUP)
Published
2022-10-01
Volume
1
Issue
2
Pages
84-102
ISSN
2755-1733 (ISSN-L)
DOI
10.1093/lifemedi/lnac053
PMC
PMC11749813
OpenAlex
W4309006001
Cited by
27
References
17
Citations by year
2026: 6 · 2025: 8 · 2024: 10 · 2023: 3
FWCI
0.55
Type
journal article
Language
en
Open access
Licence
Locations
  • Life Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Genome Institute of Singapore
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords
precision medicine, multi-omics, tumor heterogeneity, carcinogenesis, prognosis, molecular diagnosis, clinical pathology, spatial transcriptomics, spatial proteomics, spatial genomics

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