The DOI matches its Crossref record; 259 of the 259 references it cites were found in a registry or an index.
Scedosporium and Lomentospora: an updated overview of underrated opportunists
Open accessAbstract
Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.
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“Scedosporium and Lomentospora species are rare opportunistic molds demonstrating broad and even pan-resistant tendencies with mortality rates breaching 80%.”
From Investigational Agents for the Treatment of Resistant Yeasts and Molds (2021) · cites this paper as [14]
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“Currently, infections by these organisms have few, if any, reliable therapeutic options.”
From Investigational Agents for the Treatment of Resistant Yeasts and Molds (2021) · cites this paper as [14]
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Sorted by citations
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Metadata
- Authors
- Ramirez-Garcia, A., Pellon, A., Rementeria, A., Buldain, I., Barreto-Bergter, E., Rollin-Pinheiro, R., de Meirelles, J. V., Xisto, M. I. D. S., Ranque, S., Havlicek, V., Vandeputte, P., Govic, Y. L., Bouchara, J.-P., Giraud, S., Chen, S., Rainer, J., Alastruey-Izquierdo, A., Martin-Gomez, M. T., López-Soria, L. M., Peman, J., Schwarz, C., Bernhardt, A., Tintelnot, K., Capilla, J., Martin-Vicente, A., Cano-Lira, J., Nagl, M., Lackner, M., Irinyi, L., Meyer, W., de Hoog, S., & Hernando, F. L.
- Affiliations
- Fungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology and Parasitology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain
- University of the Basque Country (ES)
- Instituto de Microbiologia, UFRJ, Rio de Janeiro, RJ, Brazil
- Laboratoire de Parasitologie-Mycologie, AP-HM / CHU Timone, Marseille, France
- Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
- Centre Hospitalier Universitaire d'Angers (FR)
- Université d'Angers (FR)
- Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital, The University of Sydney, New South Wales, Australia
- Universität Innsbruck (AT)
- Mycology Reference Laboratory, National Centre for Microbiology. Instituto de Salud Carlos III. Majadahonda, Madrid, Spain
- Microbiology Department. Hospital Universitari Vall d’Hebron, Barcelona, Spain
- Microbiology Department. Hospital Universitario Cruces, Barakaldo, Spain
- Microbiology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain
- Charité – Universitätsmedizin Berlin (DE)
- Robert Koch Institute (DE)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Mycology Unit, Medical School and IISPV, Universitat Rovira i Virgili, Reus, Spain
- Innsbruck Medical University (AT)
- Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Westmead Clinical School, Sydney Medical School – Westmead Hospital, Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Westmead Institute for Medical Research, Sydney, New South Wales, Australia
- The University of Sydney (AU)
- Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands
- ORCID
- Venue
- Medical Mycology
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-03-10
- Volume
- 56
- Issue
- suppl_1
- Pages
- S102-S125
- ISSN
- 0268-1218 (ISSN-L)
- 1369-3786
- 1460-2709
- OpenAlex
- W2789742163
- Cited by
- 264
- References
- 259
- Citations by year
- 2026: 21 · 2025: 27 · 2024: 33 · 2023: 41 · 2022: 33 · 2021: 48 · 2020: 26 · 2019: 23 · 2018: 9
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Medical Mycology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- HAL (submittedVersion, other-oa)
- Communities in ADDI (University of the Basque Country) (submittedVersion, other-oa)
- Hispana (submittedVersion, other-oa)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Funders
- Czech Science Foundation (16-20229S)
- National Health and Medical Research Council of Australia (APP1031952, APP1121936)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Health Sciences › Medicine › Microbiology (medical) › Actinomycetales infections and treatment
- Keywords
- Scedosporium, opportunistic fungal infection, emerging fungal pathogens, immunocompromised patients, invasive fungal infections, antifungal resistance, fungal taxonomy, virulence factors, fungal immunology, fungal infection diagnosis, antifungal therapy, environmental distribution, lung colonization
- MeSH terms
- Antifungal Agents, Ascomycota, Combined Modality Therapy, Ecology, Humans, Mycoses, Opportunistic Infections, Surgical Procedures, Operative, Immunocompromised Host, Scedosporium, Drug Resistance, Multiple, Fungal, Virulence Factors, Host-Pathogen Interactions, Molecular Typing
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