The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Age-dependent changes in the expression of superoxide dismutases and catalase are associated with ultrastructural modifications in human granulosa cells
Abstract
Limited knowledge exists about changes in follicle quality associated with age. The aim of this work was to investigate whether ageing may cause oxidative stress-mediated alterations in human granulosa cells (GCs) from periovulatory follicles. GCs employed in this study were obtained from follicular aspirates of 20 younger women (range 27-32 years) and 20 older women (range 38-41 years) undergoing an IVF treatment. Results obtained from comparative RT-PCR analysis revealed that the mean relative levels of mRNAs coding for superoxide dismutases, Cu, ZnSOD (SOD1), MnSOD (SOD2) and catalase were significantly decreased in women > or =38 years (P < 0.05, Student's t-test). These changes were associated with a reduced expression of SOD1, SOD2 and catalase at the protein level. When examined at an ultrastructural level, most of the GCs from this group showed defective mitochondria and fewer lipid droplets than those observed in the younger group. These results indicate that GCs from older patients suffer from age-dependent oxidative stress injury and are taken as an evidence for reduced defence against reactive oxygen species (ROS) in GCs during reproductive ageing.
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Cites
Zelko, I. N., Mariani, T. J., & Folz, R. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00905-x · Cited by 2,212
Role of oxidative stress in female reproduction
Agarwal, A., Gupta, S., & Sharma, R. K. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-28 · Cited by 1,729
Cited by
Houldsworth, A. (2023) · Brain Communications · doi:10.1093/braincomms/fcad356 · Cited by 417
Could oxidative stress influence the in-vitro maturation of oocytes?
Combelles, C. M., Gupta, S., & Agarwal, A. (2009) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60038-7 · Cited by 313
Mitochondrial and sex steroid hormone crosstalk during aging
Velarde, M. C. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-2 · Cited by 96
p66Shc aging protein in control of fibroblasts cell fate
Suski, J. M., Karkucinska-Wieckowska, A., Lebiedzinska, M., Giorgi, C., Szczepanowska, J., Szabadkai, G., Duszynski, J., Pronicki, M., Pinton, P., & Wieckowski, M. R. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12085373 · Cited by 22
Tashiro, R., Ozaki, D., Bautista-Garrido, J., Sun, G., Obertas, L., Mobley, A. S., Kim, G. S., Aronowski, J., & Jung, J. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065187 · Cited by 15
Metadata
- Authors
- Tatone, C., Carbone, M. C., Falone, S., Aimola, P., Giardinelli, A., Caserta, D., Marci, R., Pandolfi, A., Ragnelli, A. M., & Amicarelli, F.
- Venue
- MHR: Basic science of reproductive medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-09-27
- Volume
- 12
- Issue
- 11
- Pages
- 655-660
- ISSN
- 1360-9947 (ISSN-L)
- 1460-2407
- OpenAlex
- W2096657831
- Cited by
- 196
- References
- 2
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Age-dependent changes in the expression of superoxide dismutases and catalase are associated with ultrastructural modifications in human granulosa cells. https://app.cochat.ai/papers/10.1093/molehr/gal080
- The paper
- Tatone, C., Carbone, M. C., Falone, S., Aimola, P., Giardinelli, A., Caserta, D., Marci, R., Pandolfi, A., Ragnelli, A. M., & Amicarelli, F. (2006). Age-dependent changes in the expression of superoxide dismutases and catalase are associated with ultrastructural modifications in human granulosa cells. MHR: Basic science of reproductive medicine. https://doi.org/10.1093/molehr/gal080
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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