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Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line

Open access
Masiakowski, P., Breathnach, R., Bloch, J., Gannon, F., Krust, A., Chambon, P.·1982·Nucleic Acids Research

Abstract

cDNA clones corresponding to a mRNA whose level is rapidly increased by addition of oestradiol to the culture medium have been isolated by differential screening of a cDNA library from the breast cancer cell line MCF-7, which contains oestrogen receptors. Such clones will be useful in studies of the DNA sequences required for hormonal induction and to determine whether expression of the corresponding gene is in any way related to the cancerous state. We have also obtained a cDNA clone for a messenger whose level is apparently decreased by steroid hormones.

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Metadata

Authors
Masiakowski, P., Breathnach, R., Bloch, J., Gannon, F., Krust, A., & Chambon, P.
Venue
Nucleic Acids Research
Published
1982
Volume
10
Issue
24
Pages
7895-7903
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2018579779
Cited by
728
References
0
FWCI
5.30
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. https://app.cochat.ai/papers/10.1093/nar/10.24.7895
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Masiakowski, P., Breathnach, R., Bloch, J., Gannon, F., Krust, A., & Chambon, P. (1982). Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Research. https://doi.org/10.1093/nar/10.24.7895

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.