PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,626 · see citing works

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,533 · see citing works

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519 · see citing works

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,858 · see citing works

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536636 · Cited by 2,217 · see citing works

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Preprint

Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., & Spiegelman, B. M. (1994) · Genes & Development · doi:10.1101/gad.8.10.1224 · Cited by 2,182 · see citing works

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90194-9 · Cited by 2,028 · see citing works

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

Luckow, B., & Schütz, G. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.13.5490 · Cited by 1,650 · see citing works

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

Kliewer, S. A., FORMAN, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., & Evans, R. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7355 · Cited by 1,400 · see citing works

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

Dreyer, C., Krey, G. D., Keller, H., Givel, F., Helftenbein, G., & Wahli, W. (1992) · Cell · doi:10.1016/0092-8674(92)90031-7 · Cited by 1,373 · see citing works

Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently

Leid, M. E., Kastner, P., Lyons, R., Nakshatri, H., Saunders, M., Zacharewski, T. R., Chen, J.-Y., Staub, A., Garnier, J., Mader, S., et al. (1992) · Cell · doi:10.1016/0092-8674(92)90478-u · Cited by 1,166 · see citing works

Dietary influences on serum lipids and lipoproteins.

Grundy, S. M., & Denke, M. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42625-2 · Cited by 1,044 · see citing works

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

Keller, H., Dreyer, C., Medin, J. A., Mahfoudi, A., Ozato, K., & Wahli, W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2160 · Cited by 948 · see citing works

The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene

Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., & Green, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05072.x · Cited by 895 · see citing works

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.

Göttlicher, M., Widmark, E., Li, Q., & Gustafsson, J.-Α. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4653 · Cited by 857 · see citing works

Insulin Resistance — Mechanisms, Syndromes, and Implications

Epstein, F. H., Moller, D. E., & Flier, J. S. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109263251307 · Cited by 800 · see citing works

Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line

Masiakowski, P., Breathnach, R., Bloch, J., et al. (1982) · Nucleic Acids Research · doi:10.1093/nar/10.24.7895 · Cited by 733 · see citing works

Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

Yu, K., Bayona, W., Kallen, C. B., Harding, H. P., Ravera, C., McMahon, G., Brown, M. A., & Lazar, M. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.23975 · Cited by 709 · see citing works

Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.

Hu, E., Tontonoz, P., & Spiegelman, B. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9856 · Cited by 658 · see citing works

The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression.

Gulick, T., Cresci, S., Caira, T., Moore, D. D., & Kelly, D. P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11012 · Cited by 560 · see citing works

PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene

Tontonoz, P., Hu, E., Devine, J. H., BEALE, E. G., & Spiegelman, B. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.351 · Cited by 559 · see citing works

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

Sher, T., Yi, H. F., McBride, O. W., & Gonzalez, F. J. (1993) · Biochemistry · doi:10.1021/bi00072a015 · Cited by 519 · see citing works

Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids

Schmidt, A., Endo, N., Rutledge, S. J., Vogel, R., SHINAR, D. M., & Rodan, G. A. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.10.1333051 · Cited by 476 · see citing works

Differential activation of adipogenesis by multiple PPAR isoforms.Preprint

Brun, R. P., Tontonoz, P., FORMAN, B. M., Ellis, R., Chen, J., Evans, R. M., & Spiegelman, B. M. (1996) · Genes & Development · doi:10.1101/gad.10.8.974 · Cited by 474 · see citing works

Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles.

Aalto‐Setälä, K., Fisher, E. A. A., Chen, X., Chajek‐Shaul, T., Hayek, T., Zechner, R., Walsh, A., Ramakrishnan, R., Ginsberg, H. N., & Breslow, J. L. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116066 · Cited by 450 · see citing works

Biochemical Mechanisms Of Induction Of Hepatic Peroxisome Proliferation

Lock, E. A., Mitchell, A. M., & Elcombe, C. R. (1989) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.29.040189.001045 · Cited by 424 · see citing works

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III.

Wang, C. S., McConathy, W. J., Kloer, H. U., & Alaupovic, P. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111711 · Cited by 414 · see citing works

Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.

Staels, B., Vu-Dac, N., Kosykh, V. A., Saladin, R., Fruchart, J. C., Dallongeville, J., & Auwerx, J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117717 · Cited by 410 · see citing works

Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor.

Vu‐Dac, N., Schoonjans, K., Kosykh, V., Dallongeville, J., Fruchart, J., Staels, B., & Auwerx, J. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118118 · Cited by 397 · see citing works

Induction of the Acyl-Coenzyme A Synthetase Gene by Fibrates and Fatty Acids Is Mediated by a Peroxisome Proliferator Response Element in the C Promoter

Schoonjans, K., 渡辺, 光., Suzuki, H., Mahfoudi, A., Krey, G. D., Wahli, W., Grimaldi, P. A., Staels, B., Yamamoto, T. T., & Auwerx, J. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.33.19269 · Cited by 395 · see citing works

Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.

Rodríguez, J. C., Gil‐Gómez, G., Hegardt, F. G., & Haro, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32234-2 · Cited by 378 · see citing works

Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.

Zhu, Y., Alvares, K., Huang, Q. M., Rao, M. S. R., & Reddy, J. K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74184-2 · Cited by 374 · see citing works

Cloning of a Protein That Mediates Transcriptional Effects of Fatty Acids in Preadipocytes

Amri, E., Bonino, F., Ailhaud, G. P., Abumrad, N. A., & Grimaldi, P. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2367 · Cited by 368 · see citing works

Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.

Hertz, R., Bishara-Shieban, J., & Bar‐Tana, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13470 · Cited by 339 · see citing works

Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha.

Wu, J. C., Merlino, G. T., & Fausto, N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.674 · Cited by 317 · see citing works

The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.

Muerhoff, A. S., Griffin, K. J., & Johnson, E. F. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41738-3 · Cited by 311 · see citing works

Enhancement of adipocyte differentiation by an insulin-sensitizing agent.

Kletzien, R. F., Clarke, S., & Ulrich, R. G. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08890-x · Cited by 284 · see citing works

Metabolic aspects of peroxisomal β-oxidation

Osmundsen, H., Bremer, J., & Pedersen, J. I. (1991) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(91)90089-z · Cited by 281 · see citing works

PPAR-RXR Heterodimer Activates a Peroxisome Proliferator Response Element Upstream of the Bifunctional Enzyme Gene

Bardot, O., Aldridge, T. C., Latruffe, N., & Green, S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1378 · Cited by 269 · see citing works

Effects of dietary cholesterol and fatty acids on plasma lipoproteins.

Schonfeld, G., Patsch, W., Rudel, L. L., Nelson, C., Epstein, M., & Olson, R. E. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110542 · Cited by 260 · see citing works

Regulation of adipose cell differentiation. I. Fatty acids are inducers of the aP2 gene expression.

Amri, E., Bertrand, B., Ailhaud, G. P., & Grimaldi, P. A. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41912-1 · Cited by 243 · see citing works

Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element.

Vu‐Dac, N., Schoonjans, K., Laine, B., Fruchart, J., Auwerx, J. H., & Staels, B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47383-8 · Cited by 240 · see citing works

Blood pressure lowering by pioglitazone. Evidence for a direct vascular effect.

Buchanan, T. A., Meehan, W. P., Jeng, Y. Y., Yang, D. T., Chan, T. M., Nadler, J. L., Scott, S., Rude, R. K., & Hsueh, W. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118041 · Cited by 237 · see citing works

Inhibition of adipogenesis by the stress‐induced protein CHOP (Gadd153).

Batchvarova, N., Wang, X. Z., & Ron, D. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00147.x · Cited by 234 · see citing works

Establishment of preadipocyte clonal line from epididymal fat pad of ob/ob mouse that responds to insulin and to lipolytic hormones

Négrel, R., Grimaldi, P., & Ailhaud, G. P. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.12.6054 · Cited by 233 · see citing works

Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase.

Zhang, B., Marcus, S. L., Sajjadi, F. G., Alvares, K., Reddy, J. K., Subramani, S. E., Rachubinski, R. A., & Capone, J. P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7541 · Cited by 232 · see citing works

Thiazolidinediones and Fatty Acids Convert Myogenic Cells into Adipose-like Cells

Teboul, L., Gaillard, D., Staccini-Lavenant, L., Inadera, H., Amri, E., & Grimaldi, P. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.47.28183 · Cited by 231 · see citing works

Structure of the human lipoprotein lipase gene

Deeb, S. S., & Peng, R. (1989) · Biochemistry · doi:10.1021/bi00436a001 · Cited by 227 · see citing works

Peroxisome proliferator and retinoid signalingpathways co-regulate preadipocyte phenotype and survival.

Chawla, A., & Lazar, M. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.5.1786 · Cited by 227 · see citing works

Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms.

Distel, R. J., Robinson, G. S., & Spiegelman, B. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42645-2 · Cited by 203 · see citing works

Two -acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene

Osumi, T., Wen, J., & Hashimoto, T. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91645-s · Cited by 197 · see citing works

Requirement and role of arachidonic acid in the differentiation of pre-adipose cells

Gaillard, D., Négrel, R., Lagarde, M., & Ailhaud, G. P. (1989) · Biochemical Journal · doi:10.1042/bj2570389 · Cited by 179 · see citing works

Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression.

Marcus, S. L., Miyata, K., Zhang, B., Subramani, S. E., Rachubinski, R. A., & Capone, J. P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5723 · Cited by 171 · see citing works

Down-regulation of the Expression of the Obese Gene by an Antidiabetic Thiazolidinedione in Zucker Diabetic Fatty Rats and db/db Mice

Zhang, B., Graziano, M. P., Doebber, T. W., Leibowitz, M. D., White-Carrington, S., Szalkowski, D., Hey, P. J., Wu, M. S., Cullinan, C. A., Bailey, P., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9455 · Cited by 171 · see citing works

Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals.

Ikeda, H., Taketomi, S., Sugiyama, Y., Shimura, Y., Sohda, T., Meguro, K., & Fujita, T. (1990) · PubMed · Cited by 151 · see citing works

CAP and RNA polymerase interactions with thelacpromoter: binding stoichiometry and long range effects

Fried, M. G., & Crothers, D. M. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.1.141 · Cited by 151 · see citing works

Lipoprotein Lipase: Recent Contributions from Molecular Biology

Auwerx, J. H., Leroy, P., & Schoonjans, K. (1992) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369209114602 · Cited by 148 · see citing works

Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects

Heller, F., & Harvengt, C. (1983) · European Journal of Clinical Pharmacology · doi:10.1007/bf00544015 · Cited by 138 · see citing works

Antidiabetic agent pioglitazone enhances adipocyte differentiation of 3T3-F442A cells

Sandouk, T., Reda, D. J., & Hofmann, C. A. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.6.c1600 · Cited by 116 · see citing works

Acyl‐CoA synthetase mRNA expression is controlled by fibric‐acid derivatives, feeding and liver proliferation

Schoonjans, K., Staels, B., Grimaldi, P. A., & Auwerx, J. H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18181.x · Cited by 109 · see citing works

Severe Obesity: Expensive to Society, Frustrating to Treat, But Important to Confront

Martin, L. F., Hunter, S. M., Lauve, R., & O'Leary, J. P. (1995) · Southern Medical Journal · doi:10.1097/00007611-199509000-00001 · Cited by 93 · see citing works

Characterization of triacylglycerol hydrolase activities in isolated myocardial cells from rat heart

Ramı́rez, I., Kryski, A. J., Ben-Zeev, O., Schotz, M. C., & Severson, D. L. (1985) · Biochemical Journal · doi:10.1042/bj2320229 · Cited by 90 · see citing works

Thiazolidine Derivatives Ameliorate High Glucose-induced Insulin Resistance via the Normalization of Protein-tyrosine Phosphatase Activities

Maegawa, H., Ide, R., Hasegawa, M., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7724 · Cited by 87 · see citing works

Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter.

Palmer, C. N., Hsu, M., Muerhoff, A. S., Griffin, K. J., & Johnson, E. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32420-1 · Cited by 83 · see citing works

cDNA cloning and characterization of the transcriptional activities of the hamster peroxisome proliferator-activated receptor haPPARγ

Aperlo, C., Pognonec, P., Saladin, R., Auwerx, J. H., & Boulukos, K. E. (1995) · Gene · doi:10.1016/0378-1119(95)00196-d · Cited by 79 · see citing works

The effects of fibrates on lipoprotein and hemostatic coronary risk factors.

Schonfeld, G. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90090-6 · Cited by 78 · see citing works

The ontogeny of peroxisome-proliferator-activated receptor gene expression in the mouse and rat

Beck, F., Plummer, S., Senior, P. V., Byrne, S., Green, S., & Brammar, W. J. (1992) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1992.0012 · Cited by 77 · see citing works

Perturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and α-fetoprotein as models

Staels, B., & Auwerx, J. H. (1992) · Development · doi:10.1242/dev.115.4.1035 · Cited by 76 · see citing works

Preadipocyte differentiation in vitro: Identification of a highly active adipogenic agent

Hiragun, A., Sato, M., & Mitsui, H. (1988) · Journal of Cellular Physiology · doi:10.1002/jcp.1041340115 · Cited by 60 · see citing works

Lipoprotein lipase gene expression in THP-1 cells

Auwerx, J. H., Deeb, S. S., Brunzell, J. D., Wolfbauer, G., & Chait, A. (1989) · Biochemistry · doi:10.1021/bi00437a009 · Cited by 43 · see citing works

Cloning and characterization of the promoter of the murine lipoprotein lipase-encoding gene: structural and functional analysis

Hua, X., Enerbäck, S., Hudson, J., Youkhana, K., & Gimble, J. M. (1991) · Gene · doi:10.1016/0378-1119(91)90325-6 · Cited by 41 · see citing works

Effect of Gemfibrozil on lipids, apoproteins, and postheparin lipolytic activities in normolipidemic subjects

Gnasso, A., Lehner, B., Haberbosch, W., Leiss, O., von Bergmann, K., & Augustin, J. (1986) · Metabolism · doi:10.1016/0026-0495(86)90125-3 · Cited by 37 · see citing works

Beneficial effects of fish-oil supplements on lipids, lipoproteins, and lipoprotein lipase in patients with glycogen storage disease type l

Levy, E. H., Thibault, L., Turgeon, J. P., ROY, C. C., Gurbindo, C., Lepage, G., Godard, M., Rivard, G., & Seidman, E. G. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.6.922 · Cited by 29 · see citing works

Low-dose colestipol plus fenofibrate: Effects on plasma liproproteins, lecithin:cholesterol acyltransferase, and postheparin lipases in familial hypercholesterolemia

Weisweiler, P. (1989) · Metabolism · doi:10.1016/0026-0495(89)90086-3 · Cited by 25 · see citing works

Antidiabetic AD4743 enhances adipocyte differentiation of 3T3 T mesenchymal stem cells

Sparks, R. L., Strauss, E. E., Zycmunt, A. I., & Phelan, T. E. (1991) · Journal of Cellular Physiology · doi:10.1002/jcp.1041460114 · Cited by 25 · see citing works

Developmental extinction of liver lipoprotein lipase mRNA expression might be regulated by an NF‐1‐like site

Schoonjans, K., Staels, B., Devos, P., et al. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80200-e · Cited by 20 · see citing works

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works

The mechanisms of action of PPARs

Berger, J., & Moller, D. E. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104018 · Cited by 2,659 · see citing works

Fat and Beyond: The Diverse Biology of PPARγ

Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061307.091829 · Cited by 2,085 · see citing works

The PPARs:  From Orphan Receptors to Drug Discovery

Willson, T. M., Brown, P. J., Sternbach, D. D., & Henke, B. R. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990554g · Cited by 1,816 · see citing works

Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism

Staels, B., Dallongeville, J., Auwerx, J., Schoonjans, K., Leitersdorf, E., & Fruchart, J.-C. (1998) · Circulation · doi:10.1161/01.cir.98.19.2088 · Cited by 1,786 · see citing works

A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

Deeb, S. S., Fajas, L., Nemoto, M., Pihlajamäki, J., Mykkänen, L., Kuusisto, J., Laakso, M., Fujimoto, W., & Auwerx, J. (1998) · Nature Genetics · doi:10.1038/3099 · Cited by 1,319 · see citing works

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

Schoonjans, K., Staels, B., & Auwerx, J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42003-6 · Cited by 1,216 · see citing works

The Peroxisome Proliferator-Activated Receptor: A Family of Nuclear Receptors Role in Various Diseases

Tyagi, S., Gupta, P., Saini, A., Kaushal, C., & Sharma, S. (2011) · Journal of Advanced Pharmaceutical Technology & Research · doi:10.4103/2231-4040.90879 · Cited by 1,017 · see citing works

Pancreatic regulation of glucose homeostasis.

Röder, P. V., Wu, B., Liu, Y., & Han, W. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.6 · Cited by 985 · see citing works

Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

Chinetti, G., Fruchart, J.-C., & Staels, B. (2000) · Inflammation Research · doi:10.1007/s000110050622 · Cited by 954 · see citing works

NADPH oxidases: An overview from structure to innate immunity-associated pathologies

Panday, A., Sahoo, M. K., Osorio, D., & Batra, S. (2015) · Cellular & Molecular Immunology · doi:10.1038/cmi.2014.89 · Cited by 944 · see citing works

Cellular Mechanisms for Insulin Resistance in Normal Pregnancy and Gestational Diabetes

Barbour, L. A., McCurdy, C. E., Hernandez, T. L., Kirwan, J. P., Catalano, P. M., & Friedman, J. E. (2007) · Diabetes Care · doi:10.2337/dc07-s202 · Cited by 811 · see citing works

PPARs in Obesity-Induced T2DM, Dyslipidaemia and NAFLD

Gross, B., Pawlak, M., Lefebvre, P., & Staels, B. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.135 · Cited by 778 · see citing works

From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions

Feige, J. N., Gelman, L., Michalik, L., Desvergne, B., & Wahli, W. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.12.002 · Cited by 786 · see citing works

A Null Mutation in Murine CD36 Reveals an Important Role in Fatty Acid and Lipoprotein Metabolism

Febbraio, M., Abumrad, N. A., Hajjar, D. P., Sharma, K., Cheng, W., Pearce, S. F. A., & Silverstein, R. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19055 · Cited by 769 · see citing works

Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach

Bays, H., Mandarino, L., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030723 · Cited by 664 · see citing works

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

Guerre-Millo, M., Gervois, P., Raspé, E., Madsen, L., Poulain, P., Derudas, B., Herbert, J.-M., Winegar, D. A., Willson, T. M., Fruchart, J.-C., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.22.16638 · Cited by 605 · see citing works

Coordinate Regulation of the Expression of the Fatty Acid Transport Protein and Acyl-CoA Synthetase Genes by PPARα and PPARγ Activators

Martin, G., Schoonjans, K., Lefebvre, A.-M., Staels, B., & Auwerx, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28210 · Cited by 551 · see citing works

Peroxisome proliterator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis

Fruchart, J.-C., Duriez, P., & Staels, B. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199906000-00007 · Cited by 425 · see citing works

Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study

Tanaka, T., Shen, J., Abecasis, G. R., Kisialiou, A., Ordovas, J. M., Guralnik, J. M., Singleton, A., Bandinelli, S., Cherubini, A., Arnett, D., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000338 · Cited by 418 · see citing works

The role of PPARα in lipid metabolism and obesity: Focusing on the effects of estrogen on PPARα actions

Yoon, M. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.02.004 · Cited by 336 · see citing works

Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study

Pradhan, A. D., Paynter, N. P., Everett, B. M., Glynn, R. J., Amarenco, P., Elam, M., Ginsberg, H., Hiatt, W. R., Ishibashi, S., Koenig, W., et al. (2018) · American Heart Journal · doi:10.1016/j.ahj.2018.09.011 · Cited by 319 · see citing works

Activation of PPARδ alters lipid metabolism in db/db mice

Leibowitz, M. D., Fiévet, C., Hennuyer, N., Peinado-Onsurbe, J., Duez, H., Berger, J., Cullinan, C. A., Sparrow, C. P., Baffic, J., Berger, G. D., et al. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01554-4 · Cited by 308 · see citing works

Anandamide induced PPARγ transcriptional activation and 3T3-L1 preadipocyte differentiation

Bouaboula, M., Hilairet, S., Marchand, J., Fajas, L., Fur, G. L., & Casellas, P. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.05.032 · Cited by 298 · see citing works

The nuclear receptor REV-ERBα is required for the daily balance of carbohydrate and lipid metabolism

Delezie, J., Dumont, S., Dardente, H., Oudart, H., Gréchez‐Cassiau, A., Klosen, P., Teboul, M., Delaunay, F., Pévet, P., & Challet, E. (2012) · The FASEB Journal · doi:10.1096/fj.12-208751 · Cited by 252 · see citing works

Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland

Bernard, L., Leroux, C., & Chilliard, Y. (2007) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-387-74087-4_2 · Cited by 249 · see citing works

Peroxisome proliferator-activated receptor-alpha (PPARα): At the crossroads of obesity, diabetes and cardiovascular disease

Fruchart, J.-C. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.03.008 · Cited by 233 · see citing works

PPARs as Nuclear Receptors for Nutrient and Energy Metabolism

Hong, F., Pan, S., Guo, Y., Xu, P., & Zhai, Y. (2019) · Molecules · doi:10.3390/molecules24142545 · Cited by 233 · see citing works

Differential Regulation of Lipoprotein Kinetics by Atorvastatin and Fenofibrate in Subjects With the Metabolic Syndrome

Watts, G. F., Barrett, P. H. R., Ji, J., Serone, A. P., Chan, D. C., Croft, K. D., Loehrer, F., & Johnson, A. G. (2003) · Diabetes · doi:10.2337/diabetes.52.3.803 · Cited by 219 · see citing works

PPARs and lipid ligands in inflammation and metabolism

Harmon, G. S., Lam, M. T., & Glass, C. K. (2011) · Chemical Reviews · doi:10.1021/cr2001355 · Cited by 216 · see citing works

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1α

Coste, A., Louet, J.-F., Lagouge, M., Lerin, C., Antal, M. C., Meziane, H., Schoonjans, K., Puigserver, P., O'Malley, B. W., & Auwerx, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808207105 · Cited by 205 · see citing works

PPARα and dyslipidemia

DUVAL, C., MULLER, M., & KERSTEN, S. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.05.003 · Cited by 199 · see citing works

Inhibition of Thymic Adipogenesis by Caloric Restriction Is Coupled with Reduction in Age-Related Thymic Involution

Yang, H., Youm, Y.-H., & Dixit, V. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900562 · Cited by 196 · see citing works

The Human Apolipoprotein AV Gene Is Regulated by Peroxisome Proliferator-activated Receptor-α and Contains a Novel Farnesoid X-activated Receptor Response Element

Prieur, X., Coste, H., & Rodríguez, J. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301302200 · Cited by 194 · see citing works

Pemafibrate, a new selective PPARα modulator: drug concept and its clinical applications for dyslipidemia and metabolic diseases

Yamashita, S., Masuda, D., & Matsuzawa, Y. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-0823-5 · Cited by 191 · see citing works

Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency

Takeda, K., Toda, K., Saibara, T., Nakagawa, M., Saika, K., Onishi, T., Sugiura, T., & Shizuta, Y. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1760237 · Cited by 182 · see citing works

Obesity, Peroxisome Proliferator-Activated Receptor, and Atherosclerosis in Type 2 Diabetes

Blaschke, F., Takata, Y., Caglayan, E., Law, R. E., & Hsueh, W. A. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000191663.12164.77 · Cited by 176 · see citing works

Effects of the PPARγ agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus

Nagashima, K., Lopez, C., Donovan, D., Ngai, C., Fontanez, N., Bensadoun, A., Fruchart-Najib, J., Holleran, S., Cohn, J. S., Ramakrishnan, R., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200523219 · Cited by 201 · see citing works

Fenofibrate: A Review of its Use in Primary Dyslipidaemia, the Metabolic Syndrome and Type 2 Diabetes Mellitus

Keating, G. M., & Croom, K. F. (2007) · Drugs · doi:10.2165/00003495-200767010-00013 · Cited by 169 · see citing works

Adrenoleukodystrophy-Related Protein Can Compensate Functionally for Adrenoleukodystrophy Protein Deficiency (X-ALD): Implications for Therapy

Netik, A., Forss-Petter, S., Holzinger, A., Molzer, B., Unterrainer, G., & Berger, J. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.5.907 · Cited by 148 · see citing works

The role and mode of action of apolipoproteins CIII and AV: synergistic actors in triglyceride metabolism?

Willems van Dijk, K., Rensen, P. C., Voshol, P. J., & Havekes, L. M. (2004) · Current Opinion in Lipidology · doi:10.1097/00041433-200406000-00002 · Cited by 154 · see citing works

LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis through Modulation of Wnt Signaling

Terrand, J., Bruban, V., Zhou, L., Gong, W., El Asmar, Z., May, P., Zurhove, K., Haffner, P., Philippe, C., Woldt, E., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806538200 · Cited by 143 · see citing works

Fibrates Suppress Fibrinogen Gene Expression in Rodents Via Activation of the Peroxisome Proliferator-Activated Receptor-

Kockx, M., Gervois, P. P., Poulain, P., Derudas, B., Peters, J. M., Gonzalez, F. J., Princen, H. M. G., Kooistra, T., & Staels, B. (1999) · Blood · doi:10.1182/blood.v93.9.2991 · Cited by 139 · see citing works

The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis

Hennuyer, N., Duplan, I., Paquet, C., Vanhoutte, J., Woitrain, E., Touche, V., Colin, S., Vallez, E., Lestavel, S., Lefebvre, P., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.03.003 · Cited by 132 · see citing works

Up-regulation of SREBP-1c and lipogenic genes in skeletal muscles after exercise training

Ikeda, S., Miyazaki, H., Nakatani, T., Kai, Y., Kamei, Y., Miura, S., Tsuboyama-Kasaoka, N., & Ezaki, O. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00883-5 · Cited by 92 · see citing works

Triglyceride-rich lipoproteins and remnants: targets for therapy?

Dallinga-Thie, G. M., Kroon, J., Borén, J., & Chapman, M. J. (2016) · Current Cardiology Reports · doi:10.1007/s11886-016-0745-6 · Cited by 90 · see citing works

Metabolic Effects of Rexinoids: Tissue-Specific Regulation of Lipoprotein Lipase Activity

Davies, P. J. A., Berry, S. A., Shipley, G. L., Eckel, R. H., Hennuyer, N., Crombie, D. L., Ogilvie, K. M., Peinado-Onsurbe, J., Fievet, C., Leibowitz, M. D., et al. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.2.170 · Cited by 89 · see citing works

Meta-analysis of primary target genes of peroxisome proliferator-activated receptors

Heinäniemi, M., Uski, J. O., Degenhardt, T., & Carlberg, C. (2007) · Genome Biology · doi:10.1186/gb-2007-8-7-r147 · Cited by 71 · see citing works

Endothelium as a gatekeeper of fatty acid transport

Mehrotra, D., Wu, J., Papangeli, I., & Chun, H. J. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.11.001 · Cited by 60 · see citing works

Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice

Takei, K., Nakagawa, Y., Wang, Y., Han, S.-I., Satoh, A., Sekiya, M., Matsuzaka, T., & Shimano, H. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.02.003 · Cited by 43 · see citing works

Resveratrol inhibits the protein expression of transcription factors related adipocyte differentiation and the activity of matrix metalloproteinase in mouse fibroblast 3T3-L1 preadipocytes

Kang, N. E., Ha, A. W., Kim, J. Y., & Kim, W. K. (2012) · Nutrition Research and Practice · doi:10.4162/nrp.2012.6.6.499 · Cited by 38 · see citing works

<i>PPARα</i> L162V polymorphism alters the potential of n‐3 fatty acids to increase lipoprotein lipase activity

Rudkowska, I., Caron‐Dorval, D., Verreault, M., Couture, P., Deshaies, Y., Barbier, O., & Vohl, M. (2010) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.200900085 · Cited by 36 · see citing works

Atorvastatin and pitavastatin enhance lipoprotein lipase production in L6 skeletal muscle cells through activation of adenosine monophosphate-activated protein kinase

Ohira, M., Endo, K., Saiki, A., Miyashita, Y., Terai, K., Murano, T., Watanabe, F., Tatsuno, I., & Shirai, K. (2012) · Metabolism · doi:10.1016/j.metabol.2012.03.010 · Cited by 25 · see citing works

“A rose is a rose is a rose … except when itʼs not.”- With apologies to Gertrude Stein*

Fein, I. A. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e31822a5e14

A Rose is a Rose is a Rose is a Rose: Essay

O’Neill, A. (2013) · University of the Arts London Research Online (University of the Arts London)

Law, Beauty, and Human Stability: A Rose Is a Rose Is a Rose

Smith, J. C., & Costonis, J. J. (1990) · California Law Review · doi:10.2307/3480845

The Final Exam: A Rose is a Rose is a Rose

Keith, S. Z. (1999) · Math Horizons · doi:10.1080/10724117.1999.12088469

A rose is a rose is a rose...is a four-letter word

Russo, N. F., & Stier, S. (1975) · PsycEXTRA Dataset · doi:10.1037/e388742004-020 · Cited by 1 · see citing works