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Cited by 183

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Unmethlated domains in vertebrate DNA

Open access
Cooper, David N., Taggart, Mary H., Bird, Adrian P.·1983·Nucleic Acids Research

Abstract

We have detected a fraction that is rich in unmethylated HpaII and HhaI sites by end-labelling HpaII fragments of chicken DNA. The fraction is not obvious when DNA fragments are stained with ethidium bromide as it amounts to less than 2% of the genome. The average frequency of sites for HpaII is over thirteen times greater in the unmethylated fraction than in total DNA. Partial digests indicate that the unmethylated sites are clustered in the genome. Similar unmethylated fractions were detected in six other vertebrates in both somatic and germ line DNA.

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Metadata

Authors
Cooper, D. N., Taggart, M. H., & Bird, A. P.
Venue
Nucleic Acids Research
Published
1983
Volume
11
Issue
3
Pages
647-658
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W1983238182
Cited by
183
References
1
FWCI
4.29
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Unmethlated domains in vertebrate DNA. https://app.cochat.ai/papers/10.1093/nar/11.3.647
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Cooper, D. N., Taggart, M. H., & Bird, A. P. (1983). Unmethlated domains in vertebrate DNA. Nucleic Acids Research. https://doi.org/10.1093/nar/11.3.647

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