DNA methylation and the frequency of CpG in animal DNA
Open accessAbstract
An analysis of nearest neighbour dinucleotide frequencies and the level of DNA methylation in animals strongly supports the suggestion that 5-methylcytosine (5mC) tends to mutate abnormally frequently to T. This tendency is the likely cause of the CpG deficiency in heavily methylated genomes.
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CpA and TpG dinucleotides are overrepresented in small DNA viruses and in the majority of RNA viruses.
“Unexpectedly, CpA and TpG dinucleotides are not only overrepresented in small DNA viruses, which might be explained by the cytosine methylation-deamination-mutation hypothesis (Bird, 1980), but also in the majority of RNA viruses.”
From Codon Pair Bias Is a Direct Consequence of Dinucleotide Bias (2016) · cites this paper as Bird, 1980
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- Authors
- Bird, A. P.
- Affiliations
- Medical Research Council (GB)
- Corresponding author
- Bird, Adrian P.
- ORCID
- Bird, Adrian P.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1980
- Volume
- 8
- Issue
- 7
- Pages
- 1499-1504
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC324012
- OpenAlex
- W2034105248
- Cited by
- 1,175
- References
- 0
- Citations by year
- 2026: 22 · 2025: 25 · 2024: 31 · 2023: 27 · 2022: 37 · 2021: 57 · 2020: 36 · 2019: 27 · 2018: 38 · 2017: 30 · 2016: 36 · 2015: 42 · 2014: 45 · 2013: 31 · 2012: 32
- FWCI
- 8.61
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nucleic Acids Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- DNA methylation, CpG, 5-methylcytosine, dinucleotide frequency, animal genomes
- MeSH terms
- Animals, Base Sequence, Cytosine, DNA, DNA Restriction Enzymes, Methylation, Mutation, Thymine, 5-Methylcytosine
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