The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
Open accessAbstract
5-Noncoding sequences have been tabulated for 211 messenger RNAs from higher eukaryotic cells. The 5'-proximal AUG triplet serves as the initiator codon in 95% of the mRNAs examined. The most conspicuous conserved feature is the presence of a purine (most often A) three nucleotides upstream from the AUG initiator codon; only 6 of the mRNAs in the survey have a pyrimidine in that position. There is a predominance of C in positions -1, -2, -4 and -5, just upstream from the initiator codon. The sequence CCAGCCAUG (G) thus emerges as a consensus sequence for eukaryotic initiation sites. The extent to which the ribosome binding site in a given mRNA matches the -1 to -5 consensus sequence varies: more than half of the mRNAs in the tabulation have 3 or 4 nucleotides in common with the CCACC consensus, but only ten mRNAs conform perfectly.
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Cites
Hamster preproglucagon contains the sequence of glucagon and two related peptides
Bell, G. I., Santerre, R. F., & Mullenbach, G. T. (1983) · Nature · doi:10.1038/302716a0 · Cited by 649
Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor
Land, H., Schütz, G., Schmale, H., & Richter, D. (1982) · Nature · doi:10.1038/295299a0 · Cited by 569
Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem
Lund, P. K., Goodman, R. H., Dee, P. C., & Habener, J. F. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.2.345 · Cited by 295
Anglerfish islet pre-proglucagon II. Nucleotide and corresponding amino acid sequence of the cDNA
Lund, P. K., Goodman, R. H., Montminy, M. R., Dee, P. C., & Habener, J. F. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32858-8 · Cited by 146
Cited by
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Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Self-citationChen, C.-J., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M., & Roninson, I. B. (1986) · Cell · doi:10.1016/0092-8674(86)90595-7 · Cited by 1,898
Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus
Weiss, S. R., & Navas-Martin, S. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.4.635-664.2005 · Cited by 1,256
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Metadata
- Authors
- Kozak, M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1984
- Volume
- 12
- Issue
- 2
- Pages
- 857-872
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2009105413
- Cited by
- 3,293
- References
- 4
- FWCI
- 92.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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